RIMB1_RAT
ID RIMB1_RAT Reviewed; 1847 AA.
AC Q9JIR0; Q9JIQ9;
DT 16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT 16-JAN-2004, sequence version 2.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Peripheral-type benzodiazepine receptor-associated protein 1;
DE Short=PRAX-1;
DE AltName: Full=RIMS-binding protein 1;
DE Short=RIM-BP1;
DE AltName: Full=TSPO-associated protein 1 {ECO:0000312|RGD:708563};
GN Name=Tspoap1 {ECO:0000312|RGD:708563}; Synonyms=Bzrap1, Rbp1;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway;
RX PubMed=15057822; DOI=10.1038/nature02426;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 55-1847 (ISOFORMS 1 AND 2), TISSUE
RP SPECIFICITY, AND INTERACTION WITH RIMS1 AND RIMS2.
RC TISSUE=Brain;
RX PubMed=10748113; DOI=10.1074/jbc.m909008199;
RA Wang Y., Sugita S., Suedhof T.C.;
RT "The RIM/NIM family of neuronal C2 domain proteins. Interactions with Rab3
RT and a new class of Src homology 3 domain proteins.";
RL J. Biol. Chem. 275:20033-20044(2000).
RN [3]
RP TISSUE SPECIFICITY.
RX PubMed=9915832; DOI=10.1074/jbc.274.5.2938;
RA Galiegue S., Jbilo O., Combes T., Bribes E., Carayon P., Le Fur G.,
RA Casellas P.;
RT "Cloning and characterization of PRAX-1. A new protein that specifically
RT interacts with the peripheral benzodiazepine receptor.";
RL J. Biol. Chem. 274:2938-2952(1999).
RN [4]
RP TISSUE SPECIFICITY.
RX PubMed=12435798; DOI=10.1124/mol.62.6.1314;
RA Chardenot P., Roubert C., Galiegue S., Casellas P., Le Fur G., Soubrie P.,
RA Oury-Donat F.;
RT "Expression profile and up-regulation of PRAX-1 mRNA by antidepressant
RT treatment in the rat brain.";
RL Mol. Pharmacol. 62:1314-1320(2002).
CC -!- SUBUNIT: Interacts with TSPO (By similarity). Interacts with RIMS1 and
CC RIMS2. {ECO:0000250, ECO:0000269|PubMed:10748113}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1; Synonyms=Rbp1A, RIM binding protein 1A;
CC IsoId=Q9JIR0-1; Sequence=Displayed;
CC Name=2; Synonyms=Rbp1B, RIM binding protein 1B;
CC IsoId=Q9JIR0-2; Sequence=VSP_009211;
CC -!- TISSUE SPECIFICITY: Specifically expressed in brain. High expression
CC level in the limbic system such as the nucleus accumbens, septum, and
CC hippocampus, as well as on the cerebellum and pineal gland. Abundant in
CC the CA1 region of the hippocampus. {ECO:0000269|PubMed:10748113,
CC ECO:0000269|PubMed:12435798, ECO:0000269|PubMed:9915832}.
CC -!- DOMAIN: The second SH3 domain mediates binding to a proline-rich motif
CC in RIMS1 and RIMS2.
CC -!- SIMILARITY: Belongs to the RIMBP family. {ECO:0000305}.
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DR EMBL; AABR03073157; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AF199337; AAF81659.1; -; mRNA.
DR EMBL; AF199338; AAF81660.1; -; mRNA.
DR AlphaFoldDB; Q9JIR0; -.
DR SMR; Q9JIR0; -.
DR STRING; 10116.ENSRNOP00000010755; -.
DR PhosphoSitePlus; Q9JIR0; -.
DR PaxDb; Q9JIR0; -.
DR PRIDE; Q9JIR0; -.
DR RGD; 708563; Tspoap1.
DR eggNOG; KOG3632; Eukaryota.
DR InParanoid; Q9JIR0; -.
DR PhylomeDB; Q9JIR0; -.
DR Reactome; R-RNO-181429; Serotonin Neurotransmitter Release Cycle.
DR Reactome; R-RNO-181430; Norepinephrine Neurotransmitter Release Cycle.
DR Reactome; R-RNO-196108; Pregnenolone biosynthesis.
DR Reactome; R-RNO-210500; Glutamate Neurotransmitter Release Cycle.
DR Reactome; R-RNO-212676; Dopamine Neurotransmitter Release Cycle.
DR Reactome; R-RNO-264642; Acetylcholine Neurotransmitter Release Cycle.
DR PRO; PR:Q9JIR0; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0044305; C:calyx of Held; ISO:RGD.
DR GO; GO:0005737; C:cytoplasm; IDA:RGD.
DR GO; GO:0098978; C:glutamatergic synapse; ISO:RGD.
DR GO; GO:0005739; C:mitochondrion; IDA:RGD.
DR GO; GO:0030156; F:benzodiazepine receptor binding; ISS:ParkinsonsUK-UCL.
DR GO; GO:0099626; F:voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels; ISO:RGD.
DR CDD; cd00063; FN3; 1.
DR CDD; cd12012; SH3_RIM-BP_2; 1.
DR CDD; cd12013; SH3_RIM-BP_3; 1.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR035753; RIM-BP_SH3_2.
DR InterPro; IPR035755; RIM-BP_SH3_3.
DR InterPro; IPR040325; RIMBP1/2/3.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR14234; PTHR14234; 1.
DR Pfam; PF07653; SH3_2; 2.
DR Pfam; PF14604; SH3_9; 1.
DR SMART; SM00060; FN3; 3.
DR SMART; SM00326; SH3; 3.
DR SUPFAM; SSF49265; SSF49265; 1.
DR SUPFAM; SSF50044; SSF50044; 3.
DR PROSITE; PS50853; FN3; 3.
DR PROSITE; PS50002; SH3; 3.
PE 1: Evidence at protein level;
KW Alternative splicing; Cytoplasm; Reference proteome; Repeat; SH3 domain.
FT CHAIN 1..1847
FT /note="Peripheral-type benzodiazepine receptor-associated
FT protein 1"
FT /id="PRO_0000221382"
FT DOMAIN 651..718
FT /note="SH3 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
FT DOMAIN 789..880
FT /note="Fibronectin type-III 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 882..974
FT /note="Fibronectin type-III 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 979..1077
FT /note="Fibronectin type-III 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 1617..1685
FT /note="SH3 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
FT DOMAIN 1756..1823
FT /note="SH3 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
FT REGION 57..81
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 282..318
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 560..626
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 728..787
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1107..1174
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1191..1215
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1240..1307
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1322..1478
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1514..1616
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1701..1747
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1818..1847
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 597..620
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 748..763
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1153..1167
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1192..1206
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1253..1267
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1403..1419
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1547..1562
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1701..1716
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1063..1121
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:10748113"
FT /id="VSP_009211"
SQ SEQUENCE 1847 AA; 200204 MW; C634B74E52736B9D CRC64;
MEQLTTLPRL GDPGAMEPWA LPAWQHWTQG QGCKPGDASA SIAATPTALQ VKGLRFEESS
EPAGAHSPGP IRNTDPEGTE TVLPKLGQQA ESPGYSCSRL EGEDAQAYKA KFNIGFGDRP
NLELLRALGE LQQHCTILKE ENQMLRKSSF PETEEKVRRL KRKNAELAVI AKRLEERAQK
LQETNMRGGE VPLCPDPDPV WSCARKALAR QRARDLSETA TALLAKDKQN AALQRECREL
QARLSLVGKE GPQWLHMRDF DRLLRESQRE VLRLQRQIAL RNQREPLRPA RSQGSTAPSS
VGAPAPGAPG ETVLEDDVES PQVVLGEPEK QLRVQQLESE LCKKRKKCES LEQEARKKQR
RCEELELQLR AAQNENARLV EENSRLSGKA TEKEQVEWEN AELKGQLLGV TQERDSALRK
SQGLQSKLES LEQVLEHMRK VAQRRQQLEE EHEQARLSLQ EKQEEVRRLQ QAQAEAKREH
EGAVQLLEST LDSMQARVRE LEGQCRSQTE RFSLLAQELQ AFRLHPGPLD LLTSALGCNA
LGDHPPPHCC CSSPQPCQGS GPKDLDLPPG SPGRCTPKSS EPALATLTGV PRRTAKKAES
LSNSSRSESI HNSPKSCPTP EVDTASEVEE LEVDSVSLLP AAPEGHSGGG ARIQVFLARY
SYNPFEGPNE NPEAELPLTA GEYIYIYGNM DEDGFFEGEL MDGRRGLVPS NFVERVSDDD
LLSTLPRELA DSSHSSGPEL SFLSGGGGGC SSGGQSSGGR SQPRPEEEAT GDELSLSPPP
EGLGEPLAVP YPRHITVLKQ LAHSVVLAWE LPPERVDLRG FHIFVNGELR QALGPGVPPK
AVLENMDLRA GPLHVSVQAL TSKGSSDPLR CCLAMGAGAG VVPSQLRIHR LTATSAEITW
VPGNSNLAHA VYLNGEECPP ARPSTYWATF CNLRPGTLYQ ARVEAQIPSQ GPWEPGWERP
ELRAATLQFT TLPAGLPDAP LDVQAEPGPS PGIVMISWLP VTIDAAGTSN GVRVTGYAVY
ADGQKIMEVA SPTAGSVLVE VSQLQLLQAC HEVTVRTMSP HGESTDSIPA PVAPALASAC
QPARMSCLSP RPSPEVRTPL ASVSPGLGYT SLPLRHPVPH GTQDSPASLS TEMSKGPQEE
PPVPCSQEEA GSAVHRTSEE KRAMEPTLGQ EGPDPVAPFL AKQAVECTSG DAGPTPCSTQ
EELTQKEPST EVCHRGDLDS ELKLRSEKEG MSELGVHLVN SLVDHSRNSD LSDIQEEEEE
EEEEEELGSR PWSFQKQVAG NSIGENGAKP QPDPSCETDS DEEILEQILE LPLQRLCSKK
LFSIPEEEEE EDEEEGLGKP GPSSSSQDPS QPERALLGLD CESSQPQGPG LCPLSPELSG
AREHLEDVLG VVGGNSRRRG GCSPEKLPNR KRPQDPREHC SRLLGNGGPQ TSARPVPPRD
RGSLPVIEGT RVGQEPGGRG RPGLSRRCPR GPAPESSLVS CLSPKCLEIS IEYDSEDEQE
VGSGGVSISS SCYPTDGEAW GTAAVGRPRG PVKVNSGSNT YLRLPAWEKG EPERRGRSAI
GRTKEPPSRA TETGESRGQD NSGRRGPQRR GARVLRTGTT ELAPPRSPQE APSHQDLPLR
VFVALFDYDP ISMSPNPDAG EEELPFREGQ ILKVFGDKDA DGFYRGESGG RTGYIPCNMV
AEVAVDTPTG RQQLLQRGFL PPNVLTQGSG NGPSVYPSAH TPGPPPKPRR SKKVELEDPA
QLCPGPPKLI HSAALKTSRP MVAAFDYNPR ENSPNMDVEA ELPFRAGDVI TVFGNMDDDG
FYYGELNGQR GLVPSNFLEG PGPEAGGLDS GTSQAESQRT RRRRVQC
