RIMB2_CHICK
ID RIMB2_CHICK Reviewed; 1325 AA.
AC Q8QFX1;
DT 16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=RIMS-binding protein 2;
DE Short=RIM-BP2;
GN Name=RIMBP2; Synonyms=RBP2;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE
RP SPECIFICITY, INTERACTION WITH RIMS1; RIMS2; CACNA1D AND CACNA1B, AND
RP FUNCTION OF SH3 DOMAIN.
RX PubMed=11988172; DOI=10.1016/s0896-6273(02)00667-0;
RA Hibino H., Pironkova R., Onwumere O., Vologodskaia M., Hudspeth A.J.,
RA Lesage F.;
RT "RIM binding proteins (RBPs) couple Rab3-interacting molecules (RIMs) to
RT voltage-gated Ca(2+) channels.";
RL Neuron 34:411-423(2002).
CC -!- FUNCTION: Plays a role in the synaptic transmission as bifunctional
CC linker that interacts simultaneously with RIMS1, RIMS2, CACNA1D and
CC CACNA1B. {ECO:0000269|PubMed:11988172}.
CC -!- SUBUNIT: Interacts with RIMS1, RIMS2, CACNA1D and CACNA1B, and
CC potentially with other Ca(2+) channel alpha-1 isoforms.
CC {ECO:0000269|PubMed:11988172}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11988172}.
CC Synapse {ECO:0000269|PubMed:11988172}. Note=Synaptic plasma membrane.
CC -!- TISSUE SPECIFICITY: Brain, cochlea and retina.
CC {ECO:0000269|PubMed:11988172}.
CC -!- DOMAIN: The SH3 domains mediate binding to a proline-rich motif in
CC RIMS1, RIMS2, CACNA1D and CACNA1B.
CC -!- SIMILARITY: Belongs to the RIMBP family. {ECO:0000305}.
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DR EMBL; AY072908; AAL67995.1; -; mRNA.
DR RefSeq; NP_989586.1; NM_204255.1.
DR AlphaFoldDB; Q8QFX1; -.
DR SMR; Q8QFX1; -.
DR STRING; 9031.ENSGALP00000004056; -.
DR PaxDb; Q8QFX1; -.
DR GeneID; 374105; -.
DR KEGG; gga:374105; -.
DR CTD; 23504; -.
DR VEuPathDB; HostDB:geneid_374105; -.
DR eggNOG; KOG3632; Eukaryota.
DR InParanoid; Q8QFX1; -.
DR OrthoDB; 102427at2759; -.
DR PhylomeDB; Q8QFX1; -.
DR PRO; PR:Q8QFX1; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045202; C:synapse; IEA:UniProtKB-SubCell.
DR GO; GO:0007274; P:neuromuscular synaptic transmission; IBA:GO_Central.
DR CDD; cd00063; FN3; 3.
DR CDD; cd12012; SH3_RIM-BP_2; 1.
DR CDD; cd12013; SH3_RIM-BP_3; 1.
DR Gene3D; 2.60.40.10; -; 2.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR035519; RIM-BP2.
DR InterPro; IPR035753; RIM-BP_SH3_2.
DR InterPro; IPR035755; RIM-BP_SH3_3.
DR InterPro; IPR040325; RIMBP1/2/3.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR14234; PTHR14234; 1.
DR PANTHER; PTHR14234:SF18; PTHR14234:SF18; 1.
DR Pfam; PF07653; SH3_2; 1.
DR Pfam; PF14604; SH3_9; 2.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00060; FN3; 3.
DR SMART; SM00326; SH3; 3.
DR SUPFAM; SSF49265; SSF49265; 2.
DR SUPFAM; SSF50044; SSF50044; 3.
DR PROSITE; PS50853; FN3; 3.
DR PROSITE; PS50002; SH3; 3.
PE 1: Evidence at protein level;
KW Cell membrane; Membrane; Reference proteome; Repeat; SH3 domain; Synapse.
FT CHAIN 1..1325
FT /note="RIMS-binding protein 2"
FT /id="PRO_0000221386"
FT DOMAIN 186..253
FT /note="SH3 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
FT DOMAIN 315..408
FT /note="Fibronectin type-III 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 411..493
FT /note="Fibronectin type-III 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 507..608
FT /note="Fibronectin type-III 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 1121..1189
FT /note="SH3 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
FT DOMAIN 1225..1292
FT /note="SH3 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
FT REGION 153..181
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 601..778
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 988..1010
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1040..1090
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 629..643
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 662..689
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 734..749
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 759..778
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1325 AA; 147538 MW; 1DD8C50D4CDA1B5B CRC64;
MREAAERRQQ LELEHEQALA VLNAKQQEIE LLQKAQVEAK KEHEGAVQLL EAKVRELEEK
CRTQSEQFNL LSRELEKFRQ QAGKIDLLSS NPLTSSDISG SPSKSLSQLM NGIATSLGKG
HESPSGSRCV ISEFIRPLQI SGDKPEQLSV KPTFLSKSRS DTPRCRFDSD MDNDQNSNTS
KQRYSGKVHL CIARYSYNPF DGPNENPEAE LPLTAGKYLY VYGDMDEDGF YEGELLDGQR
GLVPSNFVDF VQDNETRLSS TLSSEQDQNF INHSGSTLEG DILEISPPSH IDSSVISNGA
GTLDVNIDEI GEDIVPYPRK ITLIKQLAKS VIVGWEPPVV PPGWGTINSY NVLVDKEVRM
NIALGSRTKA LIEKLNISTC TYRISIQSIT NKGNSDELQC TLLVGKDVVV APSNLKVDNI
TQISAELSWL PTNSNYSHVI FLNEEEFDIV KAASYKYHFF NLKPNMAYKV KVMAKPHQMP
WQLPLEQREK KEAFVEFSTL PAGPPAPPQD VTVRAGSTQA TIQVSWKPPA LTATGTSHGA
NVTGYGVYAK GQRVAEVIFP TAENTLVELM RLRNLEAKEV TVRTLSAQGE SVDSSVAAIP
SDLLVPPSPH PRTAPKSKPL ASAGAPETKE EHLGPHLKID ESWEQTHSAS PVHGHTLEPP
VPNFPSSLQG RRSPSPNRIL PQPQGTPVPN TVAKAMAREA AQRVAESNRM ERRSVFSERS
NAAQYANSDD EEDGYDSPNV KRRGASVDDF LKGSELGKQP HYCHGEDYHT ESSRGSDLSD
IMEEDEEELY SEMQLEDGGR RRVSLTSHNA LKECNKNKTT DATFLEQPDF SQQIHHSKKL
FSIPEVAEED GEYSELLYKQ GLGMPYKKKS TIARDSRPPR PYNQDQQHNF WYPAKHRISG
MEDFTADDKG CKYSRSLSRS PDSGLDCGSE EEESRFTFRY TCDSVSANVA SSCCADTADC
SCRKSMRPLL ARRKTLTRQT SIEEDFGDLG SSFVEPRSEQ VKSSYEKKYE TQKCNRTDNL
SNEDIQGGWK NDLKMADSRA AGPLAKSSHR DAEDSLLLGN PSSAGRPERV EHAGRRSSHG
SAVPQRSRPM LVPSIDGYGG HDHLSPDIYE ESETDPGTED ISTRIFVALF DYDPLTMSPN
PDAAEEELPF KEGQIIKVYG DKDADGFYRG ETCTRIGLIP CNMVSEIQAD DEEMMDQLLK
QGFLPLNTPV EKIERNRRSG RQHSVSTRRM VALYDYDPRE SSPNVDVEAE LTFCTGDIIT
VFGEIDEDGF YYGELNGQKG LVPSNFLEEV PDDVEVYLSD APSRYLHDTP MRTKAKRKKS
VHFTP
