ID   RIMC1_DANRE             Reviewed;         276 AA.
AC   A8Y5U1; Q6PBK5;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 1.
DT   03-AUG-2022, entry version 64.
DE   RecName: Full=RAB7A-interacting MON1-CCZ1 complex subunit 1 {ECO:0000305};
DE   AltName: Full=UPF0600 protein C5orf51 homolog;
GN   Name=rimoc1; ORFNames=si:dkey-46a10.3, wu:fd42g01;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3-276.
RC   TISSUE=Retina;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the removal of damaged
CC       mitochondria via mitophagy by controlling the stability and
CC       localization of RAB7A (By similarity). Required for the recruitment of
CC       RAB7A and ATG9A vesicles to damaged mitochondria and promotes the
CC       stability of RAB7A by inhibiting its proteasomal degradation during
CC       mitophagy (By similarity). {ECO:0000250|UniProtKB:A6NDU8}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000250|UniProtKB:A6NDU8}.
CC   -!- SIMILARITY: Belongs to the RIMOC1 family. {ECO:0000305}.
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DR   EMBL; AL954357; CAP19425.1; -; Genomic_DNA.
DR   EMBL; BC059675; AAH59675.1; -; mRNA.
DR   RefSeq; NP_001121701.1; NM_001128229.1.
DR   AlphaFoldDB; A8Y5U1; -.
DR   SMR; A8Y5U1; -.
DR   PaxDb; A8Y5U1; -.
DR   PeptideAtlas; A8Y5U1; -.
DR   Ensembl; ENSDART00000061832; ENSDARP00000061831; ENSDARG00000054777.
DR   Ensembl; ENSDART00000192920; ENSDARP00000147656; ENSDARG00000111808.
DR   GeneID; 325885; -.
DR   KEGG; dre:325885; -.
DR   CTD; 285636; -.
DR   ZFIN; ZDB-GENE-030131-4610; rimoc1.
DR   eggNOG; ENOG502QUAR; Eukaryota.
DR   GeneTree; ENSGT00390000011383; -.
DR   HOGENOM; CLU_082742_0_0_1; -.
DR   InParanoid; A8Y5U1; -.
DR   OMA; GASCTTH; -.
DR   OrthoDB; 909559at2759; -.
DR   PhylomeDB; A8Y5U1; -.
DR   TreeFam; TF331577; -.
DR   PRO; PR:A8Y5U1; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 8.
DR   Bgee; ENSDARG00000054777; Expressed in testis and 27 other tissues.
DR   GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR   GO; GO:0000423; P:mitophagy; ISS:UniProtKB.
DR   InterPro; IPR037657; RIMC1.
DR   PANTHER; PTHR28494; PTHR28494; 1.
DR   Pfam; PF17716; DUF5561; 1.
PE   2: Evidence at transcript level;
KW   Autophagy; Cytoplasm; Reference proteome.
FT   CHAIN           1..276
FT                   /note="RAB7A-interacting MON1-CCZ1 complex subunit 1"
FT                   /id="PRO_0000341216"
SQ   SEQUENCE   276 AA;  32240 MW;  682AB56F705834F0 CRC64;
     MADDYRRSVE LERRIFELDN KCATLRTEKP DDDYLQNASS ILDKLKTYYR HGGESSSLPK
     LLQDYTQVVL DITFYEENKL VDQEFPEDSS PFKIQQLLQD LTEPEVLAGR LVPAQEVQSV
     LGLELLECLY WRRGALLYMY CHTLHQRKQW IKKNKATFLK CLQEGVRYLM RMLQVRNSVK
     LNDGVVFHDS ATANFLAEGI FSDTHLLTMM YIGEMCFWAV KYEDCSMDTT ERKEDRLHFR
     DIGTQILHKY VLACEGPLQG QGWNTENAKE ILSILQ