RIMC1_MOUSE
ID RIMC1_MOUSE Reviewed; 294 AA.
AC Q8BR90; Q91YM1;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=RAB7A-interacting MON1-CCZ1 complex subunit 1;
DE AltName: Full=UPF0600 protein C5orf51 homolog;
GN Name=Rimoc1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J, and NOD; TISSUE=Corpora quadrigemina;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Kidney, Lung, Pancreas, Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Plays an important role in the removal of damaged
CC mitochondria via mitophagy by controlling the stability and
CC localization of RAB7A (By similarity). Required for the recruitment of
CC RAB7A and ATG9A vesicles to damaged mitochondria and promotes the
CC stability of RAB7A by inhibiting its proteasomal degradation during
CC mitophagy (By similarity). {ECO:0000250|UniProtKB:A6NDU8}.
CC -!- SUBUNIT: Interacts with the MON1A-CCZ1B complex. Interacts with GDP-
CC bound RAB7A and promotes its interaction with the MON1A-CCZ1B complex.
CC {ECO:0000250|UniProtKB:A6NDU8}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000250|UniProtKB:A6NDU8}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8BR90-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8BR90-2; Sequence=VSP_034224, VSP_034225;
CC -!- SIMILARITY: Belongs to the RIMOC1 family. {ECO:0000305}.
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DR EMBL; AK045350; BAC32323.1; -; mRNA.
DR EMBL; AK154940; BAE32940.1; -; mRNA.
DR EMBL; BC016504; AAH16504.1; -; mRNA.
DR CCDS; CCDS27360.1; -. [Q8BR90-1]
DR RefSeq; NP_666042.2; NM_145930.2. [Q8BR90-1]
DR AlphaFoldDB; Q8BR90; -.
DR SMR; Q8BR90; -.
DR STRING; 10090.ENSMUSP00000038476; -.
DR PhosphoSitePlus; Q8BR90; -.
DR EPD; Q8BR90; -.
DR MaxQB; Q8BR90; -.
DR PaxDb; Q8BR90; -.
DR PeptideAtlas; Q8BR90; -.
DR PRIDE; Q8BR90; -.
DR Antibodypedia; 23213; 70 antibodies from 13 providers.
DR DNASU; 106064; -.
DR Ensembl; ENSMUST00000046633; ENSMUSP00000038476; ENSMUSG00000041935. [Q8BR90-1]
DR GeneID; 106064; -.
DR KEGG; mmu:106064; -.
DR UCSC; uc007vcg.1; mouse. [Q8BR90-2]
DR UCSC; uc007vch.1; mouse. [Q8BR90-1]
DR CTD; 285636; -.
DR MGI; MGI:2146232; AW549877.
DR VEuPathDB; HostDB:ENSMUSG00000041935; -.
DR eggNOG; ENOG502QW9A; Eukaryota.
DR GeneTree; ENSGT00390000011383; -.
DR HOGENOM; CLU_082742_0_0_1; -.
DR InParanoid; Q8BR90; -.
DR OMA; GASCTTH; -.
DR OrthoDB; 909559at2759; -.
DR PhylomeDB; Q8BR90; -.
DR TreeFam; TF331577; -.
DR BioGRID-ORCS; 106064; 2 hits in 72 CRISPR screens.
DR PRO; PR:Q8BR90; -.
DR Proteomes; UP000000589; Chromosome 15.
DR RNAct; Q8BR90; protein.
DR Bgee; ENSMUSG00000041935; Expressed in parotid gland and 255 other tissues.
DR Genevisible; Q8BR90; MM.
DR GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0000423; P:mitophagy; ISS:UniProtKB.
DR InterPro; IPR037657; RIMC1.
DR PANTHER; PTHR28494; PTHR28494; 1.
DR Pfam; PF17716; DUF5561; 1.
PE 1: Evidence at protein level;
KW Acetylation; Alternative splicing; Autophagy; Cytoplasm;
KW Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:A6NDU8"
FT CHAIN 2..294
FT /note="RAB7A-interacting MON1-CCZ1 complex subunit 1"
FT /id="PRO_0000341215"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:A6NDU8"
FT VAR_SEQ 1..68
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_034224"
FT VAR_SEQ 69
FT /note="Q -> M (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_034225"
SQ SEQUENCE 294 AA; 33471 MW; C5E91D1163CB71C7 CRC64;
MAAAVSGVVR RVEELGDLAQ AHIQHLSEAA GEDDHFLIRA SAALEKLKLL CGEEKECSNP
SNLLELYTQA ILDMTYFEEN KLVDEDFPED CSPQKVKELL AFLSEPEILA KESNMHPKLC
GLLGAELLEC LSWRRGALLY MYCHSLTKRR EWLLRKSNLL QKYLVDGINY LLQMLNYRCP
VQLNEGVSFQ DLDTAKLLST GVFSDIHVLA MMYSGEMCYW GLKHCTDQQS ENHEVDTDVF
GASCTTHKET LDFREVGEKI LKKYVSVCEG PLKEQEWNTA NAKQILSFFQ QRCS
