AAMDC_MOUSE
ID AAMDC_MOUSE Reviewed; 122 AA.
AC Q8R0P4; Q8BH71;
DT 13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Mth938 domain-containing protein;
DE AltName: Full=LI2;
GN Name=Aamdc;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Pancreas, and Small intestine;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=FVB/N; TISSUE=Mammary cancer, and Thymus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Lung, Pancreas, Spleen,
RC and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [4]
RP SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=21622130; DOI=10.2741/e273;
RA Wang H., Ma X., Zhang H., Zang J., Hu S., Li D.;
RT "Involvement of LOC66273 isoform 2, a novel Mth938 containing protein, in
RT MAPK pathway.";
RL Front. Biosci. 3:1241-1248(2011).
RN [5]
RP FUNCTION.
RX PubMed=22279136; DOI=10.3945/jn.111.152108;
RA Ma X., Ding W., Wang J., Wu G., Zhang H., Yin J., Zhou L., Li D.;
RT "LOC66273 isoform 2, a novel protein highly expressed in white adipose
RT tissue, induces adipogenesis in 3T3-L1 cells.";
RL J. Nutr. 142:448-455(2012).
CC -!- FUNCTION: May play a role in preadipocyte differentiation and
CC adipogenesis. {ECO:0000269|PubMed:22279136}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21622130}.
CC Note=Diffuse distribution with some highly concentrated spots around
CC the nucleus.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8R0P4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8R0P4-2; Sequence=VSP_019270;
CC -!- TISSUE SPECIFICITY: Widely expressed, with high expression in the
CC adipose tissue and skeletal muscle (at protein level).
CC {ECO:0000269|PubMed:21622130}.
CC -!- SIMILARITY: Belongs to the AAMDC family. {ECO:0000305}.
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DR EMBL; AK007558; BAC25178.1; -; mRNA.
DR EMBL; AK008195; BAC25205.1; -; mRNA.
DR EMBL; BC026557; AAH26557.1; -; mRNA.
DR EMBL; BC062811; AAH62811.1; -; mRNA.
DR CCDS; CCDS21461.1; -. [Q8R0P4-1]
DR CCDS; CCDS52314.1; -. [Q8R0P4-2]
DR RefSeq; NP_001171416.1; NM_001177945.1.
DR RefSeq; NP_001171417.1; NM_001177946.1.
DR RefSeq; NP_001171418.1; NM_001177947.1. [Q8R0P4-2]
DR RefSeq; NP_899074.2; NM_183251.3. [Q8R0P4-1]
DR RefSeq; XP_006508177.1; XM_006508114.3. [Q8R0P4-1]
DR RefSeq; XP_006508178.1; XM_006508115.2.
DR AlphaFoldDB; Q8R0P4; -.
DR SMR; Q8R0P4; -.
DR BioGRID; 211346; 2.
DR STRING; 10090.ENSMUSP00000121940; -.
DR iPTMnet; Q8R0P4; -.
DR PhosphoSitePlus; Q8R0P4; -.
DR EPD; Q8R0P4; -.
DR MaxQB; Q8R0P4; -.
DR PaxDb; Q8R0P4; -.
DR PRIDE; Q8R0P4; -.
DR ProteomicsDB; 296465; -. [Q8R0P4-1]
DR ProteomicsDB; 296466; -. [Q8R0P4-2]
DR Antibodypedia; 31275; 172 antibodies from 19 providers.
DR DNASU; 66273; -.
DR Ensembl; ENSMUST00000136757; ENSMUSP00000121940; ENSMUSG00000035642. [Q8R0P4-1]
DR Ensembl; ENSMUST00000138060; ENSMUSP00000116214; ENSMUSG00000035642. [Q8R0P4-2]
DR GeneID; 66273; -.
DR KEGG; mmu:66273; -.
DR UCSC; uc009ijl.2; mouse. [Q8R0P4-2]
DR UCSC; uc012fpj.1; mouse. [Q8R0P4-1]
DR CTD; 28971; -.
DR MGI; MGI:1913523; Aamdc.
DR VEuPathDB; HostDB:ENSMUSG00000035642; -.
DR eggNOG; ENOG502S00Z; Eukaryota.
DR GeneTree; ENSGT00390000011958; -.
DR HOGENOM; CLU_074390_4_0_1; -.
DR InParanoid; Q8R0P4; -.
DR OrthoDB; 1403160at2759; -.
DR PhylomeDB; Q8R0P4; -.
DR TreeFam; TF332083; -.
DR BioGRID-ORCS; 66273; 0 hits in 71 CRISPR screens.
DR ChiTaRS; Aamdc; mouse.
DR PRO; PR:Q8R0P4; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q8R0P4; protein.
DR Bgee; ENSMUSG00000035642; Expressed in muscle of arm and 265 other tissues.
DR ExpressionAtlas; Q8R0P4; baseline and differential.
DR Genevisible; Q8R0P4; MM.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IMP:MGI.
DR GO; GO:0045600; P:positive regulation of fat cell differentiation; IDA:MGI.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:MGI.
DR GO; GO:0006366; P:transcription by RNA polymerase II; IDA:MGI.
DR CDD; cd05126; Mth938; 1.
DR Gene3D; 3.40.1230.10; -; 1.
DR InterPro; IPR034096; AAMDC.
DR InterPro; IPR036748; MTH938-like_sf.
DR InterPro; IPR007523; NDUFAF3/AAMDC.
DR Pfam; PF04430; DUF498; 1.
DR SUPFAM; SSF64076; SSF64076; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cytoplasm; Reference proteome.
FT CHAIN 1..122
FT /note="Mth938 domain-containing protein"
FT /id="PRO_0000239815"
FT REGION 6..122
FT /note="MTH138-like domain"
FT VAR_SEQ 45..76
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_019270"
SQ SEQUENCE 122 AA; 13244 MW; 1E9BFD4770DC03FE CRC64;
MASPKIASLS WGQMKVQGST LTYKDCKVWP GGSRAWDWRE TGTEHSPGVQ PADVKEVAEK
GVQTLVIGRG MSEALKVPPS TVEYLEKQGI DVRVLQTEQA VKEYNALVAQ GVRVGGVFHS
TC
