ID   AAMP_BOVIN              Reviewed;         434 AA.
AC   Q3SZK1;
DT   20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=Angio-associated migratory cell protein;
GN   Name=AAMP;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   FUNCTION.
RX   PubMed=11969303; DOI=10.1006/mvre.2001.2384;
RA   Beckner M.E., Jagannathan S., Peterson V.A.;
RT   "Extracellular angio-associated migratory cell protein plays a positive
RT   role in angiogenesis and is regulated by astrocytes in coculture.";
RL   Microvasc. Res. 63:259-269(2002).
CC   -!- FUNCTION: Plays a role in angiogenesis and cell migration. In smooth
CC       muscle cell migration, may act through the RhoA pathway.
CC       {ECO:0000269|PubMed:11969303}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}. Cytoplasm
CC       {ECO:0000250}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC102815; AAI02816.1; -; mRNA.
DR   RefSeq; NP_001070463.1; NM_001076995.2.
DR   AlphaFoldDB; Q3SZK1; -.
DR   SMR; Q3SZK1; -.
DR   STRING; 9913.ENSBTAP00000005126; -.
DR   PaxDb; Q3SZK1; -.
DR   PRIDE; Q3SZK1; -.
DR   Ensembl; ENSBTAT00000005126; ENSBTAP00000005126; ENSBTAG00000003927.
DR   GeneID; 767919; -.
DR   KEGG; bta:767919; -.
DR   CTD; 14; -.
DR   VEuPathDB; HostDB:ENSBTAG00000003927; -.
DR   VGNC; VGNC:25445; AAMP.
DR   eggNOG; KOG0296; Eukaryota.
DR   GeneTree; ENSGT00940000153648; -.
DR   HOGENOM; CLU_000288_57_9_1; -.
DR   InParanoid; Q3SZK1; -.
DR   OMA; WMWKVPS; -.
DR   OrthoDB; 1025450at2759; -.
DR   TreeFam; TF314543; -.
DR   Reactome; R-BTA-177929; Signaling by EGFR.
DR   Reactome; R-BTA-428930; Thromboxane signalling through TP receptor.
DR   Proteomes; UP000009136; Chromosome 2.
DR   Bgee; ENSBTAG00000003927; Expressed in retina and 107 other tissues.
DR   GO; GO:0009986; C:cell surface; ISS:UniProtKB.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0045171; C:intercellular bridge; IEA:Ensembl.
DR   GO; GO:0015630; C:microtubule cytoskeleton; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008201; F:heparin binding; IEA:Ensembl.
DR   GO; GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0045766; P:positive regulation of angiogenesis; NAS:UniProtKB.
DR   GO; GO:0010595; P:positive regulation of endothelial cell migration; IMP:UniProtKB.
DR   GO; GO:0014909; P:smooth muscle cell migration; ISS:UniProtKB.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR024977; Apc4_WD40_dom.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF12894; ANAPC4_WD40; 1.
DR   Pfam; PF00400; WD40; 3.
DR   SMART; SM00320; WD40; 8.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 6.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Angiogenesis; Cell membrane; Cytoplasm; Developmental protein;
KW   Differentiation; Membrane; Phosphoprotein; Reference proteome; Repeat;
KW   WD repeat.
FT   CHAIN           1..434
FT                   /note="Angio-associated migratory cell protein"
FT                   /id="PRO_0000278193"
FT   REPEAT          89..129
FT                   /note="WD 1"
FT   REPEAT          132..171
FT                   /note="WD 2"
FT   REPEAT          173..212
FT                   /note="WD 3"
FT   REPEAT          214..254
FT                   /note="WD 4"
FT   REPEAT          258..299
FT                   /note="WD 5"
FT   REPEAT          315..354
FT                   /note="WD 6"
FT   REPEAT          356..395
FT                   /note="WD 7"
FT   REPEAT          398..433
FT                   /note="WD 8"
FT   REGION          1..63
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        30..63
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         20
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q13685"
SQ   SEQUENCE   434 AA;  46829 MW;  A30C5979D7A8DCC0 CRC64;
     MESESESGAA ADTPPLETLS FHGDEEIIEV VELDPGPPDP DDLVQEMEDV DFEEEEEEEG
     NEEGWVLEPQ EGVVGSMEGP DDSEVTFALH SASVFCVSLD PKTNTLAVTG GEDDKAFVWR
     LSDGELLFEC AGHKDSVTCA GFSHDSTLVA TGDMSGLLKV WQVDTKEEVW SFEAGDLEWM
     EWHPRAPVLL AGTADGNTWM WKVPTGDCKT FQGPNCPATC GRVLPDGKRA VVGYEDGTIR
     IWDLKQGNSI HVLKGTEGHQ GPLTCVATNQ DGSLILTGSV DCQAKLVSAT TGKVVGVFRP
     ETVASQPSLG EGEESESNSV ESLGFCSVMP LAAVGYLDGT LAIYDLSTQT LRHQCQHQSG
     IVQLLWEAGT AVVYTCSLDG IVRLWDARTG RLLTDYRGHT AEILDFALSK DASLVVTTSG
     DHKAKVFCVQ RPDR