RIMS3_MOUSE
ID RIMS3_MOUSE Reviewed; 307 AA.
AC Q80U57;
DT 16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT 16-JAN-2004, sequence version 2.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=Regulating synaptic membrane exocytosis protein 3;
DE Short=Nim3;
DE AltName: Full=RIM3 gamma;
DE AltName: Full=Rab-3-interacting molecule 3;
DE Short=RIM 3;
GN Name=Rims3; Synonyms=Kiaa0237;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=12620390; DOI=10.1016/s0888-7543(02)00024-1;
RA Wang Y., Suedhof T.C.;
RT "Genomic definition of RIM proteins: evolutionary amplification of a family
RT of synaptic regulatory proteins.";
RL Genomics 81:126-137(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 45-307.
RC TISSUE=Brain;
RX PubMed=12693553; DOI=10.1093/dnares/10.1.35;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S.,
RA Nakajima D., Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: II.
RT The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 10:35-48(2003).
RN [3]
RP SEQUENCE REVISION.
RA Okazaki N., Kikuno R., Nagase T., Ohara O., Koga H.;
RL Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-294 AND SER-297, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Regulates synaptic membrane exocytosis. {ECO:0000250}.
CC -!- SUBUNIT: Binds PPFIA3 (By similarity). Does not bind RAB3.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Synapse {ECO:0000250}.
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DR EMBL; AY326953; AAQ01680.1; -; mRNA.
DR EMBL; AK122226; BAC65508.2; -; mRNA.
DR CCDS; CCDS18595.1; -.
DR RefSeq; NP_891559.1; NM_182929.2.
DR RefSeq; XP_006503164.1; XM_006503101.1.
DR RefSeq; XP_006503165.1; XM_006503102.1.
DR AlphaFoldDB; Q80U57; -.
DR SMR; Q80U57; -.
DR BioGRID; 232439; 7.
DR STRING; 10090.ENSMUSP00000068178; -.
DR iPTMnet; Q80U57; -.
DR PhosphoSitePlus; Q80U57; -.
DR MaxQB; Q80U57; -.
DR PaxDb; Q80U57; -.
DR PRIDE; Q80U57; -.
DR ProteomicsDB; 253288; -.
DR Antibodypedia; 18011; 101 antibodies from 29 providers.
DR Ensembl; ENSMUST00000071093; ENSMUSP00000068178; ENSMUSG00000032890.
DR Ensembl; ENSMUST00000106283; ENSMUSP00000101890; ENSMUSG00000032890.
DR Ensembl; ENSMUST00000171363; ENSMUSP00000130295; ENSMUSG00000032890.
DR GeneID; 242662; -.
DR KEGG; mmu:242662; -.
DR UCSC; uc008unr.1; mouse.
DR CTD; 9783; -.
DR MGI; MGI:2443331; Rims3.
DR VEuPathDB; HostDB:ENSMUSG00000032890; -.
DR eggNOG; KOG2060; Eukaryota.
DR GeneTree; ENSGT00940000159332; -.
DR HOGENOM; CLU_071205_0_0_1; -.
DR InParanoid; Q80U57; -.
DR OMA; HIAMMDR; -.
DR OrthoDB; 109268at2759; -.
DR PhylomeDB; Q80U57; -.
DR TreeFam; TF315600; -.
DR BioGRID-ORCS; 242662; 3 hits in 71 CRISPR screens.
DR ChiTaRS; Rims3; mouse.
DR PRO; PR:Q80U57; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q80U57; protein.
DR Bgee; ENSMUSG00000032890; Expressed in medial dorsal nucleus of thalamus and 101 other tissues.
DR ExpressionAtlas; Q80U57; baseline and differential.
DR Genevisible; Q80U57; MM.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR GO; GO:0048788; C:cytoskeleton of presynaptic active zone; IBA:GO_Central.
DR GO; GO:0098978; C:glutamatergic synapse; ISO:MGI.
DR GO; GO:0099524; C:postsynaptic cytosol; ISO:MGI.
DR GO; GO:0042734; C:presynaptic membrane; IBA:GO_Central.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0044325; F:transmembrane transporter binding; IDA:MGI.
DR GO; GO:0048791; P:calcium ion-regulated exocytosis of neurotransmitter; IBA:GO_Central.
DR GO; GO:0017156; P:calcium-ion regulated exocytosis; ISS:ParkinsonsUK-UCL.
DR GO; GO:0050806; P:positive regulation of synaptic transmission; IBA:GO_Central.
DR GO; GO:0042391; P:regulation of membrane potential; IDA:MGI.
DR GO; GO:0050807; P:regulation of synapse organization; ISO:MGI.
DR GO; GO:0048167; P:regulation of synaptic plasticity; IBA:GO_Central.
DR GO; GO:2000300; P:regulation of synaptic vesicle exocytosis; ISO:MGI.
DR Gene3D; 2.60.40.150; -; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR039032; Rim-like.
DR PANTHER; PTHR12157; PTHR12157; 1.
DR Pfam; PF00168; C2; 1.
DR SMART; SM00239; C2; 1.
DR SUPFAM; SSF49562; SSF49562; 1.
DR PROSITE; PS50004; C2; 1.
PE 1: Evidence at protein level;
KW Exocytosis; Neurotransmitter transport; Phosphoprotein; Reference proteome;
KW Synapse; Transport.
FT CHAIN 1..307
FT /note="Regulating synaptic membrane exocytosis protein 3"
FT /id="PRO_0000190205"
FT DOMAIN 155..273
FT /note="C2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT REGION 86..120
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 104..120
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 294
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 297
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
SQ SEQUENCE 307 AA; 32589 MW; FB6D0AAF6A41C704 CRC64;
MFNGEPGPAS AGASRNVVRS SSISGEICGS QQAGGGAGTT TAKKRRSSLG AKMVAIVGLT
QWSKSTLQLP QPEGATKKLR SNIRRSTETG IAVEMRSRVT RQGSRESTDG STNSNSSEGT
FIFPTRLGAE SQFSDFLDGL GPAQIVGRQT LATPPMGDVH IAIMDRSGQL EVEVIEARGL
TPKPGSKSLP ATYIKAYLLE NGACVAKKKT KVAKKTCDPL YQQALLFDEG PQGKVLQVIV
WGDYGRMDHK CFMGMAQIML DELDLSAAVT GWYKLFPTSS VADSTLGSLT RRLSQSSLES
ATSPSCS