ID   RIMS4_MOUSE             Reviewed;         269 AA.
AC   P60191;
DT   16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT   16-JAN-2004, sequence version 1.
DT   03-AUG-2022, entry version 119.
DE   RecName: Full=Regulating synaptic membrane exocytosis protein 4;
DE   AltName: Full=RIM4 gamma;
DE   AltName: Full=Rab3-interacting molecule 4;
DE            Short=RIM 4;
GN   Name=Rims4;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=12620390; DOI=10.1016/s0888-7543(02)00024-1;
RA   Wang Y., Suedhof T.C.;
RT   "Genomic definition of RIM proteins: evolutionary amplification of a family
RT   of synaptic regulatory proteins.";
RL   Genomics 81:126-137(2003).
RN   [2]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-254 AND SER-257, AND
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brain;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- FUNCTION: Regulates synaptic membrane exocytosis. {ECO:0000250}.
CC   -!- SUBUNIT: Binds PPFIA3 (By similarity). Does not bind RAB3.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Synapse {ECO:0000250}.
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DR   EMBL; AY326955; AAQ01682.1; -; mRNA.
DR   CCDS; CCDS17018.1; -.
DR   RefSeq; NP_898844.1; NM_183023.1.
DR   AlphaFoldDB; P60191; -.
DR   SMR; P60191; -.
DR   IntAct; P60191; 1.
DR   MINT; P60191; -.
DR   STRING; 10090.ENSMUSP00000045637; -.
DR   iPTMnet; P60191; -.
DR   PhosphoSitePlus; P60191; -.
DR   MaxQB; P60191; -.
DR   PaxDb; P60191; -.
DR   PRIDE; P60191; -.
DR   ProteomicsDB; 255273; -.
DR   Antibodypedia; 43706; 118 antibodies from 25 providers.
DR   DNASU; 241770; -.
DR   Ensembl; ENSMUST00000044734; ENSMUSP00000045637; ENSMUSG00000035226.
DR   GeneID; 241770; -.
DR   KEGG; mmu:241770; -.
DR   UCSC; uc008nto.1; mouse.
DR   CTD; 140730; -.
DR   MGI; MGI:2674366; Rims4.
DR   VEuPathDB; HostDB:ENSMUSG00000035226; -.
DR   eggNOG; KOG2060; Eukaryota.
DR   GeneTree; ENSGT00940000158934; -.
DR   HOGENOM; CLU_071205_0_0_1; -.
DR   InParanoid; P60191; -.
DR   OMA; GLYMERS; -.
DR   OrthoDB; 109268at2759; -.
DR   PhylomeDB; P60191; -.
DR   BioGRID-ORCS; 241770; 2 hits in 71 CRISPR screens.
DR   ChiTaRS; Rims4; mouse.
DR   PRO; PR:P60191; -.
DR   Proteomes; UP000000589; Chromosome 2.
DR   RNAct; P60191; protein.
DR   Bgee; ENSMUSG00000035226; Expressed in lumbar subsegment of spinal cord and 94 other tissues.
DR   Genevisible; P60191; MM.
DR   GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR   GO; GO:0098978; C:glutamatergic synapse; ISO:MGI.
DR   GO; GO:0045202; C:synapse; ISO:MGI.
DR   GO; GO:0097060; C:synaptic membrane; IDA:MGI.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0044325; F:transmembrane transporter binding; IDA:MGI.
DR   GO; GO:0006887; P:exocytosis; IEA:UniProtKB-KW.
DR   GO; GO:0006836; P:neurotransmitter transport; IEA:UniProtKB-KW.
DR   GO; GO:0042391; P:regulation of membrane potential; IDA:MGI.
DR   GO; GO:0050807; P:regulation of synapse organization; ISO:MGI.
DR   GO; GO:2000300; P:regulation of synaptic vesicle exocytosis; ISS:ParkinsonsUK-UCL.
DR   Gene3D; 2.60.40.150; -; 1.
DR   InterPro; IPR000008; C2_dom.
DR   InterPro; IPR035892; C2_domain_sf.
DR   InterPro; IPR039032; Rim-like.
DR   PANTHER; PTHR12157; PTHR12157; 1.
DR   Pfam; PF00168; C2; 1.
DR   SMART; SM00239; C2; 1.
DR   SUPFAM; SSF49562; SSF49562; 1.
DR   PROSITE; PS50004; C2; 1.
PE   1: Evidence at protein level;
KW   Exocytosis; Neurotransmitter transport; Phosphoprotein; Reference proteome;
KW   Synapse; Transport.
FT   CHAIN           1..269
FT                   /note="Regulating synaptic membrane exocytosis protein 4"
FT                   /id="PRO_0000190208"
FT   DOMAIN          115..233
FT                   /note="C2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT   MOD_RES         254
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:21183079"
FT   MOD_RES         257
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:21183079"
SQ   SEQUENCE   269 AA;  29329 MW;  5CB33B573A9CECAC CRC64;
     MERSQSRLSL SASFEALAIY FPCMNSFDDE DAADSRRLKG AIQRSTETGL AVEMPSRTLR
     QASHESIEDS MNSYGSEGNL NYGGVCLASD AQFSDFLGSM GPAQFVGRQT LATTPMGDVE
     IGLQERNGQL EVDIIQARGL TAKPGSKTLP AAYIKAYLLE NGVCIAKKKT KVARKSLDPL
     YNQVLLFPES PQGKVLQVIV WGNYGRMERK QFMGVARVLL EELDLTTLAV GWYKLFPTSS
     MVDPATGPLL RQASQLSLES TVGPCGERS