ID   RIMS4_RAT               Reviewed;         269 AA.
AC   Q8CIX1;
DT   16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Regulating synaptic membrane exocytosis protein 4;
DE   AltName: Full=RIM4 gamma;
DE   AltName: Full=Rab3-interacting molecule 4;
DE            Short=RIM 4;
GN   Name=Rims4;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH PPFIA3, AND TISSUE
RP   SPECIFICITY.
RX   PubMed=12620390; DOI=10.1016/s0888-7543(02)00024-1;
RA   Wang Y., Suedhof T.C.;
RT   "Genomic definition of RIM proteins: evolutionary amplification of a family
RT   of synaptic regulatory proteins.";
RL   Genomics 81:126-137(2003).
CC   -!- FUNCTION: Regulates synaptic membrane exocytosis. {ECO:0000250}.
CC   -!- SUBUNIT: Binds PPFIA3.
CC   -!- SUBCELLULAR LOCATION: Synapse {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Brain specific. {ECO:0000269|PubMed:12620390}.
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DR   EMBL; AF548739; AAN59931.1; -; mRNA.
DR   RefSeq; NP_733766.1; NM_170666.1.
DR   AlphaFoldDB; Q8CIX1; -.
DR   SMR; Q8CIX1; -.
DR   STRING; 10116.ENSRNOP00000014499; -.
DR   PaxDb; Q8CIX1; -.
DR   PRIDE; Q8CIX1; -.
DR   GeneID; 266976; -.
DR   KEGG; rno:266976; -.
DR   UCSC; RGD:628695; rat.
DR   CTD; 140730; -.
DR   RGD; 628695; Rims4.
DR   eggNOG; KOG2060; Eukaryota.
DR   InParanoid; Q8CIX1; -.
DR   OrthoDB; 109268at2759; -.
DR   PhylomeDB; Q8CIX1; -.
DR   PRO; PR:Q8CIX1; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR   GO; GO:0098978; C:glutamatergic synapse; IDA:SynGO.
DR   GO; GO:0098793; C:presynapse; IEA:GOC.
DR   GO; GO:0045202; C:synapse; IDA:SynGO.
DR   GO; GO:0097060; C:synaptic membrane; ISS:ParkinsonsUK-UCL.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0044325; F:transmembrane transporter binding; ISS:ParkinsonsUK-UCL.
DR   GO; GO:0006887; P:exocytosis; IEA:UniProtKB-KW.
DR   GO; GO:0007269; P:neurotransmitter secretion; NAS:RGD.
DR   GO; GO:0042391; P:regulation of membrane potential; ISS:ParkinsonsUK-UCL.
DR   GO; GO:0050807; P:regulation of synapse organization; IDA:SynGO.
DR   GO; GO:2000300; P:regulation of synaptic vesicle exocytosis; IMP:MGI.
DR   Gene3D; 2.60.40.150; -; 1.
DR   InterPro; IPR000008; C2_dom.
DR   InterPro; IPR035892; C2_domain_sf.
DR   InterPro; IPR039032; Rim-like.
DR   PANTHER; PTHR12157; PTHR12157; 1.
DR   Pfam; PF00168; C2; 1.
DR   SMART; SM00239; C2; 1.
DR   SUPFAM; SSF49562; SSF49562; 1.
DR   PROSITE; PS50004; C2; 1.
PE   1: Evidence at protein level;
KW   Exocytosis; Neurotransmitter transport; Phosphoprotein; Reference proteome;
KW   Synapse; Transport.
FT   CHAIN           1..269
FT                   /note="Regulating synaptic membrane exocytosis protein 4"
FT                   /id="PRO_0000190209"
FT   DOMAIN          115..233
FT                   /note="C2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT   MOD_RES         254
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H426"
FT   MOD_RES         257
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H426"
SQ   SEQUENCE   269 AA;  29271 MW;  21ACDB643A9FDC9E CRC64;
     MERSQSRLSL SASFEALAIY FPCMNSFDDE DAADSRRLKG AIQRSTETGL AVEMPSRTLR
     QASHESIEDS MNSYGSEGNL NYGGVCLASD AQFSDFLGSM GPAQFVGRQT LATTPMGGVE
     IGLQERNGQL EVDIIQARGL TAKPGSKTLP AAYIKAYLLE NGVCIAKKKT KVARKSLDPL
     YNQVLLFPES PQGKVLQVIV WGNYGRMERK QFMGVARVLL EELDLTTLAV GWYKLFPTSS
     MVDPATGPLL RQASQLSLES TVGPCGERS