ID   RIN13_ARATH             Reviewed;         430 AA.
AC   Q9SK71;
DT   23-FEB-2022, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 128.
DE   RecName: Full=RPM1 interacting protein 13 {ECO:0000303|PubMed:15722472};
GN   Name=RIN13 {ECO:0000303|PubMed:15722472};
GN   OrderedLocusNames=At2g20310 {ECO:0000312|Araport:AT2G20310};
GN   ORFNames=F11A3.14 {ECO:0000312|EMBL:AAD21757.1};
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10617197; DOI=10.1038/45471;
RA   Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA   Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA   Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA   Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA   Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA   Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA   Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT   "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL   Nature 402:761-768(1999).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RA   de los Reyes C., Quan R., Chen H., Bautista V., Kim C.J., Ecker J.R.;
RT   "Arabidopsis ORF clones.";
RL   Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   FUNCTION, DISRUPTION PHENOTYPE, AND INTERACTION WITH RPM1.
RC   STRAIN=cv. Col-5, and cv. Columbia;
RX   PubMed=15722472; DOI=10.1105/tpc.104.028720;
RA   Al-Daoude A., de Torres Zabala M., Ko J.-H., Grant M.;
RT   "RIN13 is a positive regulator of the plant disease resistance protein
RT   RPM1.";
RL   Plant Cell 17:1016-1028(2005).
RN   [5]
RP   FUNCTION, SUBCELLULAR LOCATION, AND INTERACTION WITH ARF1.
RX   PubMed=32446355; DOI=10.1016/j.bbrc.2020.04.082;
RA   Liu X., Liu H., Liu W.-C., Gao Z.;
RT   "The nuclear localized RIN13 induces cell death through interacting with
RT   ARF1.";
RL   Biochem. Biophys. Res. Commun. 527:124-130(2020).
CC   -!- FUNCTION: Resistance protein interactor which positively enhances RPM1-
CC       mediated resistance to necrotrophic bacterial pathogens Pseudomonas
CC       syringae pv. tomato DC3000 harboring type III effector protein AvrRpm1
CC       or AvrB, but prevents the hypersensitive response (HR) controlled by
CC       RPM1 (PubMed:15722472). Together with ARF1, promotes leaf senescence
CC       and cell death, probably by facilitating the translocation of ARF1 into
CC       the nucleus, and activates ROS-related enzymes (e.g. POD, CAT and SOD)
CC       (PubMed:32446355). {ECO:0000269|PubMed:15722472,
CC       ECO:0000269|PubMed:32446355}.
CC   -!- SUBUNIT: Interacts with RPM1 (via its NB-ARC domain) (PubMed:15722472).
CC       Binds to ARF1 in the nucleus (PubMed:32446355).
CC       {ECO:0000269|PubMed:15722472, ECO:0000269|PubMed:32446355}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:32446355}.
CC   -!- DISRUPTION PHENOTYPE: Normal hypersensitive response (HR) but impaired
CC       ability to suppress bacterial growth upon infection by the necrotrophic
CC       bacterial pathogens Pseudomonas syringae pv. tomato DC3000 harboring
CC       type III effector protein AvrRpm1 or AvrB.
CC       {ECO:0000269|PubMed:15722472}.
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DR   EMBL; AC006569; AAD21757.1; -; Genomic_DNA.
DR   EMBL; CP002685; AEC06992.1; -; Genomic_DNA.
DR   EMBL; BT033116; ACF20471.1; -; mRNA.
DR   PIR; F84587; F84587.
DR   RefSeq; NP_179621.1; NM_127590.6.
DR   AlphaFoldDB; Q9SK71; -.
DR   STRING; 3702.AT2G20310.1; -.
DR   PaxDb; Q9SK71; -.
DR   PRIDE; Q9SK71; -.
DR   ProteomicsDB; 183829; -.
DR   EnsemblPlants; AT2G20310.1; AT2G20310.1; AT2G20310.
DR   GeneID; 816550; -.
DR   Gramene; AT2G20310.1; AT2G20310.1; AT2G20310.
DR   KEGG; ath:AT2G20310; -.
DR   Araport; AT2G20310; -.
DR   TAIR; locus:2038977; AT2G20310.
DR   eggNOG; ENOG502QRK3; Eukaryota.
DR   HOGENOM; CLU_614453_0_0_1; -.
DR   InParanoid; Q9SK71; -.
DR   OMA; CAYWCIA; -.
DR   OrthoDB; 1019358at2759; -.
DR   PhylomeDB; Q9SK71; -.
DR   Proteomes; UP000006548; Chromosome 2.
DR   ExpressionAtlas; Q9SK71; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR   GO; GO:0008219; P:cell death; IMP:UniProtKB.
DR   GO; GO:0042742; P:defense response to bacterium; IMP:TAIR.
DR   GO; GO:0010150; P:leaf senescence; IMP:UniProtKB.
DR   GO; GO:0034051; P:negative regulation of plant-type hypersensitive response; IMP:UniProtKB.
DR   GO; GO:0009626; P:plant-type hypersensitive response; IMP:TAIR.
DR   GO; GO:1900426; P:positive regulation of defense response to bacterium; IMP:UniProtKB.
PE   1: Evidence at protein level;
KW   Hypersensitive response; Nucleus; Plant defense; Reference proteome.
FT   CHAIN           1..430
FT                   /note="RPM1 interacting protein 13"
FT                   /id="PRO_0000454727"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          231..300
FT                   /note="Nuclear localization"
FT                   /evidence="ECO:0000303|PubMed:32446355"
SQ   SEQUENCE   430 AA;  47936 MW;  9996C3C1B81DAAED CRC64;
     MGSGNHVDIV DVSSGEEDVD TRGDVEYTDW LNGVMEPVDD TSDSTDIVEV LSEVRGGVNS
     QYRKPNSSNQ ALEDDDDCVI LDCDPDKTRE TTSVDDDDDD DVLVVGQKGE IACRDFPHPR
     HSCAKYAFNS TSHEKYCDMC HCYVCDIRAP CPYWCIAVSS IDHCHANDKE KIWKNQREYF
     RTGYMPTAPS SKPTPSILRV PKNTLLRKNH VEIRPCSSST RVANPSSVKA RHRIRQPIPH
     NQGLQSQPAQ SLSTVRDSVI QKDRSSYRFS LRSRVASSAG NGISIRFNNA QVSQSSHHSS
     STVAPTLNPE TYTQQRNVRD HCTALPGSQS NVFTRHADQN IRGSGNRQFQ TNVDRFAPSK
     APLTAEDSHT ATVQQQPGIN ENVLETKLSE FEKWLMENPN PTGPVSPLPE PGNQDYASTL
     SFDFETFLND