RINI_MOUSE
ID RINI_MOUSE Reviewed; 456 AA.
AC Q91VI7; Q924P4;
DT 25-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 153.
DE RecName: Full=Ribonuclease inhibitor;
DE AltName: Full=Ribonuclease/angiogenin inhibitor 1;
GN Name=Rnh1; Synonyms=Rnh;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Melnick M.B., Comb M.J.;
RT "Mouse homolog of ribonuclease/angiogenesis inhibitor.";
RL Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Kidney;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=NMRI; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas,
RC Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and ANG.
CC May play a role in redox homeostasis (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Forms high-affinity heterodimers with RNASE1, ANG and RNASE2.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- DOMAIN: The LRR domain forms a horseshoe-shaped structure that
CC interacts tightly with target RNases via a large protein interaction
CC surface on its interior side. {ECO:0000250}.
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DR EMBL; AF071546; AAK68859.1; -; mRNA.
DR EMBL; AK133822; BAE21862.1; -; mRNA.
DR EMBL; AK141351; BAE24659.1; -; mRNA.
DR EMBL; AK147059; BAE27643.1; -; mRNA.
DR EMBL; BC010331; AAH10331.1; -; mRNA.
DR CCDS; CCDS22002.1; -.
DR RefSeq; NP_001165571.1; NM_001172100.1.
DR RefSeq; NP_001165572.1; NM_001172101.1.
DR RefSeq; NP_660117.2; NM_145135.3.
DR PDB; 3TSR; X-ray; 2.20 A; E/F/G/H=1-456.
DR PDBsum; 3TSR; -.
DR AlphaFoldDB; Q91VI7; -.
DR SMR; Q91VI7; -.
DR BioGRID; 223500; 14.
DR IntAct; Q91VI7; 4.
DR MINT; Q91VI7; -.
DR STRING; 10090.ENSMUSP00000101651; -.
DR iPTMnet; Q91VI7; -.
DR PhosphoSitePlus; Q91VI7; -.
DR SwissPalm; Q91VI7; -.
DR UCD-2DPAGE; Q91VI7; -.
DR CPTAC; non-CPTAC-3997; -.
DR EPD; Q91VI7; -.
DR jPOST; Q91VI7; -.
DR MaxQB; Q91VI7; -.
DR PaxDb; Q91VI7; -.
DR PeptideAtlas; Q91VI7; -.
DR PRIDE; Q91VI7; -.
DR ProteomicsDB; 255277; -.
DR Antibodypedia; 22490; 474 antibodies from 31 providers.
DR DNASU; 107702; -.
DR Ensembl; ENSMUST00000106033; ENSMUSP00000101651; ENSMUSG00000038650.
DR Ensembl; ENSMUST00000167493; ENSMUSP00000133061; ENSMUSG00000038650.
DR GeneID; 107702; -.
DR KEGG; mmu:107702; -.
DR UCSC; uc009kjs.2; mouse.
DR CTD; 6050; -.
DR MGI; MGI:1195456; Rnh1.
DR VEuPathDB; HostDB:ENSMUSG00000038650; -.
DR eggNOG; KOG4308; Eukaryota.
DR GeneTree; ENSGT00940000161492; -.
DR HOGENOM; CLU_002274_4_6_1; -.
DR InParanoid; Q91VI7; -.
DR OMA; GGNDIHA; -.
DR OrthoDB; 710473at2759; -.
DR PhylomeDB; Q91VI7; -.
DR BioGRID-ORCS; 107702; 4 hits in 70 CRISPR screens.
DR ChiTaRS; Rnh1; mouse.
DR PRO; PR:Q91VI7; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q91VI7; protein.
DR Bgee; ENSMUSG00000038650; Expressed in vault of skull and 264 other tissues.
DR ExpressionAtlas; Q91VI7; baseline and differential.
DR Genevisible; Q91VI7; MM.
DR GO; GO:0032311; C:angiogenin-PRI complex; ISO:MGI.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0008428; F:ribonuclease inhibitor activity; ISO:MGI.
DR GO; GO:0045765; P:regulation of angiogenesis; ISO:MGI.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR041302; LRR_RI_cap.
DR Pfam; PF13516; LRR_6; 7.
DR Pfam; PF18779; LRR_RI_capping; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Acetylation; Cytoplasm; Leucine-rich repeat; Phosphoprotein;
KW Reference proteome; Repeat.
FT CHAIN 1..456
FT /note="Ribonuclease inhibitor"
FT /id="PRO_0000097344"
FT REPEAT 15..43
FT /note="LRR 1"
FT REPEAT 44..71
FT /note="LRR 2"
FT REPEAT 72..100
FT /note="LRR 3"
FT REPEAT 101..128
FT /note="LRR 4"
FT REPEAT 129..157
FT /note="LRR 5"
FT REPEAT 158..185
FT /note="LRR 6"
FT REPEAT 186..214
FT /note="LRR 7"
FT REPEAT 215..242
FT /note="LRR 8"
FT REPEAT 243..271
FT /note="LRR 9"
FT REPEAT 272..299
FT /note="LRR 10"
FT REPEAT 300..328
FT /note="LRR 11"
FT REPEAT 329..356
FT /note="LRR 12"
FT REPEAT 357..385
FT /note="LRR 13"
FT REPEAT 386..413
FT /note="LRR 14"
FT REPEAT 414..442
FT /note="LRR 15"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0000250|UniProtKB:P10775"
FT MOD_RES 86
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P13489"
FT CONFLICT 11
FT /note="S -> G (in Ref. 1; AAK68859)"
FT /evidence="ECO:0000305"
FT CONFLICT 68
FT /note="V -> A (in Ref. 1; AAK68859)"
FT /evidence="ECO:0000305"
FT CONFLICT 254
FT /note="R -> G (in Ref. 1; AAK68859)"
FT /evidence="ECO:0000305"
FT CONFLICT 278
FT /note="K -> N (in Ref. 1; AAK68859)"
FT /evidence="ECO:0000305"
FT CONFLICT 448
FT /note="E -> G (in Ref. 1; AAK68859)"
FT /evidence="ECO:0000305"
FT STRAND 1..7
FT /evidence="ECO:0007829|PDB:3TSR"
FT HELIX 12..22
FT /evidence="ECO:0007829|PDB:3TSR"
FT STRAND 26..33
FT /evidence="ECO:0007829|PDB:3TSR"
FT HELIX 37..39
FT /evidence="ECO:0007829|PDB:3TSR"
FT HELIX 40..48
FT /evidence="ECO:0007829|PDB:3TSR"
FT STRAND 55..57
FT /evidence="ECO:0007829|PDB:3TSR"
FT HELIX 64..74
FT /evidence="ECO:0007829|PDB:3TSR"
FT STRAND 84..86
FT /evidence="ECO:0007829|PDB:3TSR"
FT HELIX 94..99
FT /evidence="ECO:0007829|PDB:3TSR"
FT HELIX 100..106
FT /evidence="ECO:0007829|PDB:3TSR"
FT STRAND 112..114
FT /evidence="ECO:0007829|PDB:3TSR"
FT HELIX 121..132
FT /evidence="ECO:0007829|PDB:3TSR"
FT STRAND 140..143
FT /evidence="ECO:0007829|PDB:3TSR"
FT HELIX 151..153
FT /evidence="ECO:0007829|PDB:3TSR"
FT HELIX 154..163
FT /evidence="ECO:0007829|PDB:3TSR"
FT STRAND 169..171
FT /evidence="ECO:0007829|PDB:3TSR"
FT HELIX 178..191
FT /evidence="ECO:0007829|PDB:3TSR"
FT STRAND 198..200
FT /evidence="ECO:0007829|PDB:3TSR"
FT HELIX 208..210
FT /evidence="ECO:0007829|PDB:3TSR"
FT HELIX 211..220
FT /evidence="ECO:0007829|PDB:3TSR"
FT STRAND 226..228
FT /evidence="ECO:0007829|PDB:3TSR"
FT STRAND 231..233
FT /evidence="ECO:0007829|PDB:3TSR"
FT HELIX 235..246
FT /evidence="ECO:0007829|PDB:3TSR"
FT STRAND 255..257
FT /evidence="ECO:0007829|PDB:3TSR"
FT HELIX 265..277
FT /evidence="ECO:0007829|PDB:3TSR"
FT STRAND 283..285
FT /evidence="ECO:0007829|PDB:3TSR"
FT HELIX 292..303
FT /evidence="ECO:0007829|PDB:3TSR"
FT STRAND 312..314
FT /evidence="ECO:0007829|PDB:3TSR"
FT HELIX 322..324
FT /evidence="ECO:0007829|PDB:3TSR"
FT HELIX 325..334
FT /evidence="ECO:0007829|PDB:3TSR"
FT STRAND 340..342
FT /evidence="ECO:0007829|PDB:3TSR"
FT HELIX 349..360
FT /evidence="ECO:0007829|PDB:3TSR"
FT STRAND 369..371
FT /evidence="ECO:0007829|PDB:3TSR"
FT HELIX 379..381
FT /evidence="ECO:0007829|PDB:3TSR"
FT HELIX 382..391
FT /evidence="ECO:0007829|PDB:3TSR"
FT STRAND 397..399
FT /evidence="ECO:0007829|PDB:3TSR"
FT HELIX 407..417
FT /evidence="ECO:0007829|PDB:3TSR"
FT STRAND 426..428
FT /evidence="ECO:0007829|PDB:3TSR"
FT HELIX 436..448
FT /evidence="ECO:0007829|PDB:3TSR"
FT STRAND 453..455
FT /evidence="ECO:0007829|PDB:3TSR"
SQ SEQUENCE 456 AA; 49816 MW; 007B782F05A357E8 CRC64;
MSLDIQCEQL SDARWTELLP LIQQYEVVRL DDCGLTEVRC KDISSAVQAN PALTELSLRT
NELGDGGVGL VLQGLQNPTC KIQKLSLQNC GLTEAGCGIL PGMLRSLSTL RELHLNDNPM
GDAGLKLLCE GLQDPQCRLE KLQLEYCNLT ATSCEPLASV LRVKADFKEL VLSNNDLHEP
GVRILCQGLK DSACQLESLK LENCGITAAN CKDLCDVVAS KASLQELDLS SNKLGNAGIA
ALCPGLLLPS CKLRTLWLWE CDITAEGCKD LCRVLRAKQS LKELSLASNE LKDEGARLLC
ESLLEPGCQL ESLWIKTCSL TAASCPYFCS VLTKSRSLLE LQMSSNPLGD EGVQELCKAL
SQPDTVLREL WLGDCDVTNS GCSSLANVLL ANRSLRELDL SNNCMGGPGV LQLLESLKQP
SCTLQQLVLY DIYWTNEVEE QLRALEEERP SLRIIS
