RINO1_ORYSJ
ID RINO1_ORYSJ Reviewed; 510 AA.
AC O64437; Q10QK8;
DT 20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT 16-MAY-2006, sequence version 2.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Inositol-3-phosphate synthase 1 {ECO:0000305};
DE Short=MIP synthase 1 {ECO:0000305};
DE EC=5.5.1.4 {ECO:0000305};
DE AltName: Full=Myo-inositol 1-phosphate synthase {ECO:0000305};
DE Short=IPS {ECO:0000305};
DE Short=MI-1-P synthase {ECO:0000305};
DE AltName: Full=OsINO1-1 {ECO:0000303|PubMed:20213122};
GN Name=RINO1 {ECO:0000303|PubMed:9880347};
GN Synonyms=INO1 {ECO:0000305}, INO1-1 {ECO:0000303|PubMed:20213122};
GN OrderedLocusNames=Os03g0192700 {ECO:0000312|EMBL:BAS82735.1},
GN LOC_Os03g09250 {ECO:0000312|EMBL:ABF94419.1};
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RC STRAIN=cv. Kamenoo;
RX PubMed=9880347; DOI=10.1104/pp.119.1.65;
RA Yoshida K.T., Wada T., Koyama H., Mizobuchi-Fukuoka R., Naito S.;
RT "Temporal and spatial patterns of accumulation of the transcript of Myo-
RT inositol-1-phosphate synthase and phytin-containing particles during seed
RT development in rice.";
RL Plant Physiol. 119:65-72(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=cv. Kamenoo;
RA Yoon U.H., Kim Y.H.;
RT "Molecular cloning of the inositol-3-phosphate synthase genes in rice.";
RL Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16109971; DOI=10.1101/gr.3869505;
RG The rice chromosome 3 sequencing consortium;
RA Buell C.R., Yuan Q., Ouyang S., Liu J., Zhu W., Wang A., Maiti R., Haas B.,
RA Wortman J., Pertea M., Jones K.M., Kim M., Overton L., Tsitrin T.,
RA Fadrosh D., Bera J., Weaver B., Jin S., Johri S., Reardon M., Webb K.,
RA Hill J., Moffat K., Tallon L., Van Aken S., Lewis M., Utterback T.,
RA Feldblyum T., Zismann V., Iobst S., Hsiao J., de Vazeille A.R.,
RA Salzberg S.L., White O., Fraser C.M., Yu Y., Kim H., Rambo T., Currie J.,
RA Collura K., Kernodle-Thompson S., Wei F., Kudrna K., Ammiraju J.S.S.,
RA Luo M., Goicoechea J.L., Wing R.A., Henry D., Oates R., Palmer M.,
RA Pries G., Saski C., Simmons J., Soderlund C., Nelson W., de la Bastide M.,
RA Spiegel L., Nascimento L., Huang E., Preston R., Zutavern T., Palmer L.,
RA O'Shaughnessy A., Dike S., McCombie W.R., Minx P., Cordum H., Wilson R.,
RA Jin W., Lee H.R., Jiang J., Jackson S.;
RT "Sequence, annotation, and analysis of synteny between rice chromosome 3
RT and diverged grass species.";
RL Genome Res. 15:1284-1291(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [5]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [6]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT "The genomes of Oryza sativa: a history of duplications.";
RL PLoS Biol. 3:266-281(2005).
RN [8]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=12869764; DOI=10.1126/science.1081288;
RG The rice full-length cDNA consortium;
RT "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT japonica rice.";
RL Science 301:376-379(2003).
RN [9]
RP INDUCTION.
RX PubMed=11975732; DOI=10.1034/j.1399-3054.2002.1140411.x;
RA Yoshida K.T., Fujiwara T., Naito S.;
RT "The synergistic effects of sugar and abscisic acid on myo-inositol-1-
RT phosphate synthase expression.";
RL Physiol. Plantarum 114:581-587(2002).
RN [10]
RP TISSUE SPECIFICITY.
RX PubMed=17961936; DOI=10.1016/j.gene.2007.09.006;
RA Suzuki M., Tanaka K., Kuwano M., Yoshida K.T.;
RT "Expression pattern of inositol phosphate-related enzymes in rice (Oryza
RT sativa L.): implications for the phytic acid biosynthetic pathway.";
RL Gene 405:55-64(2007).
RN [11]
RP FUNCTION.
RX PubMed=19021878; DOI=10.1111/j.1467-7652.2008.00375.x;
RA Kuwano M., Mimura T., Takaiwa F., Yoshida K.T.;
RT "Generation of stable 'low phytic acid' transgenic rice through antisense
RT repression of the 1D-myo-inositol 3-phosphate synthase gene (RINO1) using
RT the 18-kDa oleosin promoter.";
RL Plant Biotechnol. J. 7:96-105(2009).
RN [12]
RP IDENTIFICATION BY MASS SPECTROMETRY.
RX PubMed=20213122; DOI=10.1007/s00425-010-1127-8;
RA Ray S., Patra B., Das-Chatterjee A., Ganguli A., Majumder A.L.;
RT "Identification and organization of chloroplastic and cytosolic L-myo-
RT inositol 1-phosphate synthase coding gene(s) in Oryza sativa: comparison
RT with the wild halophytic rice, Porteresia coarctata.";
RL Planta 231:1211-1227(2010).
RN [13]
RP INDUCTION BY ABSCISIC ACID.
RX PubMed=24467907; DOI=10.1016/j.plantsci.2013.12.015;
RA Matsuno K., Fujimura T.;
RT "Induction of phytic acid synthesis by abscisic acid in suspension-cultured
RT cells of rice.";
RL Plant Sci. 217:152-157(2014).
CC -!- FUNCTION: Involved in myo-inositol synthesis. Is a key enzyme in the
CC phytic acid biosynthesis pathway in seeds.
CC {ECO:0000269|PubMed:19021878}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate;
CC Xref=Rhea:RHEA:10716, ChEBI:CHEBI:58401, ChEBI:CHEBI:61548;
CC EC=5.5.1.4; Evidence={ECO:0000305};
CC -!- COFACTOR:
CC Name=NAD(+); Xref=ChEBI:CHEBI:57540; Evidence={ECO:0000305};
CC -!- PATHWAY: Polyol metabolism; myo-inositol biosynthesis; myo-inositol
CC from D-glucose 6-phosphate: step 1/2. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q38862}.
CC -!- TISSUE SPECIFICITY: Highly expressed in embryos, but transcripts are
CC undetectable in roots, leaves, flowers and anthers.
CC {ECO:0000269|PubMed:17961936}.
CC -!- DEVELOPMENTAL STAGE: Expressed in the apical region of globular-stage
CC embryos 2 days after anthesis (DAA). Expressed in the scutellum and
CC aleurone layer 4 DAA. Expression in these cells increases until 7 DAA,
CC and then gradually decreases. {ECO:0000269|PubMed:9880347}.
CC -!- INDUCTION: Induced by sucrose and glucose (PubMed:11975732). Induced by
CC abscisic acid (ABA) (PubMed:11975732, PubMed:24467907).
CC {ECO:0000269|PubMed:11975732, ECO:0000269|PubMed:24467907}.
CC -!- MISCELLANEOUS: Plants silencing RINO1 show a low phytic acid phenotype
CC in seeds, and high accumulation of inorganic phosphate (Pi) in seeds.
CC {ECO:0000269|PubMed:19021878}.
CC -!- SIMILARITY: Belongs to the myo-inositol 1-phosphate synthase family.
CC {ECO:0000305}.
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DR EMBL; AB012107; BAA25729.1; -; mRNA.
DR EMBL; EU267961; ACA50483.1; -; mRNA.
DR EMBL; AC116604; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DP000009; ABF94419.1; -; Genomic_DNA.
DR EMBL; AP008209; BAF11156.1; -; Genomic_DNA.
DR EMBL; AP014959; BAS82735.1; -; Genomic_DNA.
DR EMBL; CM000140; EEE58482.1; -; Genomic_DNA.
DR EMBL; AK058750; BAG86795.1; -; mRNA.
DR EMBL; AK103501; BAG96116.1; -; mRNA.
DR RefSeq; XP_015632437.1; XM_015776951.1.
DR AlphaFoldDB; O64437; -.
DR SMR; O64437; -.
DR STRING; 4530.OS03T0192700-01; -.
DR PaxDb; O64437; -.
DR PRIDE; O64437; -.
DR EnsemblPlants; Os03t0192700-01; Os03t0192700-01; Os03g0192700.
DR GeneID; 4331917; -.
DR Gramene; Os03t0192700-01; Os03t0192700-01; Os03g0192700.
DR KEGG; osa:4331917; -.
DR eggNOG; KOG0693; Eukaryota.
DR HOGENOM; CLU_021486_2_0_1; -.
DR InParanoid; O64437; -.
DR OMA; EHDLFIQ; -.
DR OrthoDB; 451916at2759; -.
DR BRENDA; 5.5.1.4; 4460.
DR PlantReactome; R-OSA-1119378; Myo-inositol biosynthesis.
DR PlantReactome; R-OSA-1119434; Phytic acid biosynthesis (lipid-independent).
DR SABIO-RK; O64437; -.
DR UniPathway; UPA00823; UER00787.
DR Proteomes; UP000000763; Chromosome 3.
DR Proteomes; UP000007752; Chromosome 3.
DR Proteomes; UP000059680; Chromosome 3.
DR Genevisible; O64437; OS.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0004512; F:inositol-3-phosphate synthase activity; IBA:GO_Central.
DR GO; GO:0006021; P:inositol biosynthetic process; IBA:GO_Central.
DR GO; GO:0008654; P:phospholipid biosynthetic process; IEA:UniProtKB-KW.
DR InterPro; IPR002587; Myo-inos-1-P_Synthase.
DR InterPro; IPR013021; Myo-inos-1-P_Synthase_GAPDH.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR11510; PTHR11510; 1.
DR Pfam; PF01658; Inos-1-P_synth; 1.
DR Pfam; PF07994; NAD_binding_5; 1.
DR PIRSF; PIRSF015578; Myoinos-ppht_syn; 1.
DR SUPFAM; SSF51735; SSF51735; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Inositol biosynthesis; Isomerase; Lipid biosynthesis;
KW Lipid metabolism; NAD; Phospholipid biosynthesis; Phospholipid metabolism;
KW Reference proteome.
FT CHAIN 1..510
FT /note="Inositol-3-phosphate synthase 1"
FT /id="PRO_0000195195"
FT CONFLICT 185
FT /note="F -> V (in Ref. 1; BAA25729)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 510 AA; 56264 MW; 20DD8DFAD199F937 CRC64;
MFIESFRVES PHVRYGAAEI ESDYQYDTTE LVHESHDGAS RWIVRPKSVR YNFRTTTTVP
KLGVMLVGWG GNNGSTLTAG VIANREGISW ATKDKVQQAN YYGSLTQAST IRVGSYNGEE
IYAPFKSLLP MVNPDDLVFG GWDISNMNLA DAMTRAKVLD IDLQKQLRPY MESMVPLPGI
YDPDFIAANQ GSRANNVIKG TKKEQMEQII KDIREFKEKS KVDKVVVLWT ANTERYSNVC
VGLNDTMENL LASVDKNEAE ISPSTLYAIA CVMEGIPFIN GSPQNTFVPG LIDLAIKNNC
LIGGDDFKSG QTKMKSVLVD FLVGAGIKPT SIVSYNHLGN NDGMNLSAPQ TFRSKEISKS
NVVDDMVSSN AILYELGEHP DHVVVIKYVP YVGDSKRAMD EYTSEIFMGG KSTIVLHNTC
EDSLLAAPII LDLVLLAELS TRIQLKAEGE EKFHSFHPVA TILSYLTKAP LVPPGTPVVN
ALAKQRAMLE NIMRACVGLA PENNMILEYK
