ID   RINO2_ORYSJ             Reviewed;         509 AA.
AC   Q8S5N2;
DT   30-AUG-2017, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   03-AUG-2022, entry version 134.
DE   RecName: Full=Inositol-3-phosphate synthase 1 {ECO:0000305};
DE            Short=MIP synthase 1 {ECO:0000305};
DE            EC=5.5.1.4 {ECO:0000305};
DE   AltName: Full=Myo-inositol 1-phosphate synthase {ECO:0000305};
DE            Short=IPS {ECO:0000305};
DE            Short=MI-1-P synthase {ECO:0000305};
DE   AltName: Full=OsINO1-2 {ECO:0000305};
GN   Name=RINO2 {ECO:0000303|PubMed:17961936}; Synonyms=INO1-2 {ECO:0000305};
GN   OrderedLocusNames=Os10g0369900 {ECO:0000312|EMBL:BAF26368.1},
GN   LOC_Os10g22450 {ECO:0000312|EMBL:AAP53373.1};
GN   ORFNames=OJ1003C07.7 {ECO:0000312|EMBL:AAM08827.1},
GN   OsJ_31267 {ECO:0000312|EMBL:EAZ15847.1};
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=12791992; DOI=10.1126/science.1083523;
RA   Yu Y., Rambo T., Currie J., Saski C., Kim H.-R., Collura K., Thompson S.,
RA   Simmons J., Yang T.-J., Nah G., Patel A.J., Thurmond S., Henry D.,
RA   Oates R., Palmer M., Pries G., Gibson J., Anderson H., Paradkar M.,
RA   Crane L., Dale J., Carver M.B., Wood T., Frisch D., Engler F.,
RA   Soderlund C., Palmer L.E., Teytelman L., Nascimento L., De la Bastide M.,
RA   Spiegel L., Ware D., O'Shaughnessy A., Dike S., Dedhia N., Preston R.,
RA   Huang E., Ferraro K., Kuit K., Miller B., Zutavern T., Katzenberger F.,
RA   Muller S., Balija V., Martienssen R.A., Stein L., Minx P., Johnson D.,
RA   Cordum H., Mardis E., Cheng Z., Jiang J., Wilson R., McCombie W.R.,
RA   Wing R.A., Yuan Q., Ouyang S., Liu J., Jones K.M., Gansberger K.,
RA   Moffat K., Hill J., Tsitrin T., Overton L., Bera J., Kim M., Jin S.,
RA   Tallon L., Ciecko A., Pai G., Van Aken S., Utterback T., Reidmuller S.,
RA   Bormann J., Feldblyum T., Hsiao J., Zismann V., Blunt S., de Vazeille A.R.,
RA   Shaffer T., Koo H., Suh B., Yang Q., Haas B., Peterson J., Pertea M.,
RA   Volfovsky N., Wortman J., White O., Salzberg S.L., Fraser C.M., Buell C.R.,
RA   Messing J., Song R., Fuks G., Llaca V., Kovchak S., Young S., Bowers J.E.,
RA   Paterson A.H., Johns M.A., Mao L., Pan H., Dean R.A.;
RT   "In-depth view of structure, activity, and evolution of rice chromosome
RT   10.";
RL   Science 300:1566-1569(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16100779; DOI=10.1038/nature03895;
RG   International rice genome sequencing project (IRGSP);
RT   "The map-based sequence of the rice genome.";
RL   Nature 436:793-800(2005).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=18089549; DOI=10.1093/nar/gkm978;
RG   The rice annotation project (RAP);
RT   "The rice annotation project database (RAP-DB): 2008 update.";
RL   Nucleic Acids Res. 36:D1028-D1033(2008).
RN   [4]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA   Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA   Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA   Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA   Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT   "Improvement of the Oryza sativa Nipponbare reference genome using next
RT   generation sequence and optical map data.";
RL   Rice 6:4-4(2013).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA   Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA   Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA   Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA   Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA   Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA   Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA   Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA   Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA   Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA   Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA   Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA   Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA   Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA   McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT   "The genomes of Oryza sativa: a history of duplications.";
RL   PLoS Biol. 3:266-281(2005).
RN   [6]
RP   TISSUE SPECIFICITY.
RX   PubMed=17961936; DOI=10.1016/j.gene.2007.09.006;
RA   Suzuki M., Tanaka K., Kuwano M., Yoshida K.T.;
RT   "Expression pattern of inositol phosphate-related enzymes in rice (Oryza
RT   sativa L.): implications for the phytic acid biosynthetic pathway.";
RL   Gene 405:55-64(2007).
CC   -!- FUNCTION: Involved in myo-inositol synthesis. Is a key enzyme in the
CC       phytic acid biosynthesis pathway in seeds.
CC       {ECO:0000250|UniProtKB:O64437}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate;
CC         Xref=Rhea:RHEA:10716, ChEBI:CHEBI:58401, ChEBI:CHEBI:61548;
CC         EC=5.5.1.4; Evidence={ECO:0000305};
CC   -!- COFACTOR:
CC       Name=NAD(+); Xref=ChEBI:CHEBI:57540; Evidence={ECO:0000305};
CC   -!- PATHWAY: Polyol metabolism; myo-inositol biosynthesis; myo-inositol
CC       from D-glucose 6-phosphate: step 1/2. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q38862}.
CC   -!- TISSUE SPECIFICITY: Highly expressed in anthers, but transcripts are
CC       undetectable in roots, leaves, flowers and embryos.
CC       {ECO:0000269|PubMed:17961936}.
CC   -!- SIMILARITY: Belongs to the myo-inositol 1-phosphate synthase family.
CC       {ECO:0000305}.
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DR   EMBL; AC113335; AAM08827.1; -; Genomic_DNA.
DR   EMBL; DP000086; AAP53373.1; -; Genomic_DNA.
DR   EMBL; AP008216; BAF26368.1; -; Genomic_DNA.
DR   EMBL; AP014966; BAT10553.1; -; Genomic_DNA.
DR   EMBL; CM000147; EAZ15847.1; -; Genomic_DNA.
DR   RefSeq; XP_015614733.1; XM_015759247.1.
DR   AlphaFoldDB; Q8S5N2; -.
DR   SMR; Q8S5N2; -.
DR   STRING; 4530.OS10T0369900-01; -.
DR   PaxDb; Q8S5N2; -.
DR   PRIDE; Q8S5N2; -.
DR   EnsemblPlants; Os10t0369900-01; Os10t0369900-01; Os10g0369900.
DR   GeneID; 4348467; -.
DR   Gramene; Os10t0369900-01; Os10t0369900-01; Os10g0369900.
DR   KEGG; osa:4348467; -.
DR   eggNOG; KOG0693; Eukaryota.
DR   HOGENOM; CLU_021486_2_0_1; -.
DR   InParanoid; Q8S5N2; -.
DR   OMA; WDINSAN; -.
DR   OrthoDB; 451916at2759; -.
DR   BRENDA; 5.5.1.4; 4460.
DR   UniPathway; UPA00823; UER00787.
DR   Proteomes; UP000000763; Chromosome 10.
DR   Proteomes; UP000007752; Chromosome 10.
DR   Proteomes; UP000059680; Chromosome 10.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0004512; F:inositol-3-phosphate synthase activity; IBA:GO_Central.
DR   GO; GO:0006021; P:inositol biosynthetic process; IBA:GO_Central.
DR   GO; GO:0008654; P:phospholipid biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR002587; Myo-inos-1-P_Synthase.
DR   InterPro; IPR013021; Myo-inos-1-P_Synthase_GAPDH.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR11510; PTHR11510; 1.
DR   Pfam; PF01658; Inos-1-P_synth; 1.
DR   Pfam; PF07994; NAD_binding_5; 1.
DR   PIRSF; PIRSF015578; Myoinos-ppht_syn; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Inositol biosynthesis; Isomerase; Lipid biosynthesis;
KW   Lipid metabolism; NAD; Phospholipid biosynthesis; Phospholipid metabolism;
KW   Reference proteome.
FT   CHAIN           1..509
FT                   /note="Inositol-3-phosphate synthase 1"
FT                   /id="PRO_0000441031"
SQ   SEQUENCE   509 AA;  56015 MW;  2E4EDD0F77F377C7 CRC64;
     MFVEGFRVES PRVRYGDGEI ESEYRYDTTE VVAPPSPEKG WVVRPKSVTY HFKTTTTVPK
     LGVMLVGWGG NNGTTLTAGV IANREGISWA TKEKVHKANY FGSLTQSSTI RVGSYNGEEI
     YAPFKSLVPM VNPNDIVFGG WDISSMNLAD AMTRARVLDI DLQKQLRHHM ESMVPLPGVY
     NPDFIAANQG SRANNVIKGT KKEQVEQVKK DIREFKEKSK VDKVVVLWTA NTERYSNVVA
     GMNDTMDNLL ASLDKDEPEM SPSTLYAIAC VMEGVPFING SPQNTFVPGL IELAIKKNSV
     IGGDDFKSGQ TKMKSVLVDF LVGAGIKPTS IASYNHLGNN DGMNLSAPQT FRSKEISKSG
     VVDDMVSSNA ILYEPGEHPD HVIVIKYIPY VGDSKRAMDE YTSEIFMGGK NTIVLHNTCE
     DSLLAAPIIL DLVLLAELST RIQLKAEDQD KYHSFHPVAT ILSYLSKAPL VPPGTPVVNA
     LAKQRAMLEN ILRACVGLAP ENNMMLEYK