ID   AAMP_CANLF              Reviewed;         435 AA.
AC   Q7YR70;
DT   26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=Angio-associated migratory cell protein;
GN   Name=AAMP;
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX   NCBI_TaxID=9615;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=12809679; DOI=10.1016/s0888-7543(03)00078-8;
RA   Lowe J.K., Kukekova A.V., Kirkness E.F., Langlois M.C., Aguirre G.D.,
RA   Acland G.M., Ostrander E.A.;
RT   "Linkage mapping of the primary disease locus for collie eye anomaly.";
RL   Genomics 82:86-95(2003).
CC   -!- FUNCTION: Plays a role in angiogenesis and cell migration. In smooth
CC       muscle cell migration, may act through the RhoA pathway (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}. Cytoplasm
CC       {ECO:0000250}.
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DR   EMBL; AY197355; AAO38199.1; -; Genomic_DNA.
DR   RefSeq; NP_001013872.1; NM_001013850.1.
DR   AlphaFoldDB; Q7YR70; -.
DR   SMR; Q7YR70; -.
DR   STRING; 9615.ENSCAFP00000066802; -.
DR   PaxDb; Q7YR70; -.
DR   Ensembl; ENSCAFT00000023220; ENSCAFP00000021562; ENSCAFG00000014625.
DR   Ensembl; ENSCAFT00030041790; ENSCAFP00030036455; ENSCAFG00030022661.
DR   Ensembl; ENSCAFT00845047061; ENSCAFP00845036933; ENSCAFG00845026688.
DR   GeneID; 478908; -.
DR   KEGG; cfa:478908; -.
DR   CTD; 14; -.
DR   VEuPathDB; HostDB:ENSCAFG00845026688; -.
DR   VGNC; VGNC:37412; AAMP.
DR   eggNOG; KOG0296; Eukaryota.
DR   GeneTree; ENSGT00940000153648; -.
DR   HOGENOM; CLU_000288_57_9_1; -.
DR   InParanoid; Q7YR70; -.
DR   OMA; WMWKVPS; -.
DR   OrthoDB; 1025450at2759; -.
DR   TreeFam; TF314543; -.
DR   Reactome; R-CFA-168638; NOD1/2 Signaling Pathway.
DR   Reactome; R-CFA-177929; Signaling by EGFR.
DR   Reactome; R-CFA-428930; Thromboxane signalling through TP receptor.
DR   Proteomes; UP000002254; Chromosome 37.
DR   GO; GO:0009986; C:cell surface; ISS:UniProtKB.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0045171; C:intercellular bridge; IEA:Ensembl.
DR   GO; GO:0015630; C:microtubule cytoskeleton; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008201; F:heparin binding; IEA:Ensembl.
DR   GO; GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0010595; P:positive regulation of endothelial cell migration; ISS:UniProtKB.
DR   GO; GO:0014909; P:smooth muscle cell migration; ISS:UniProtKB.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR024977; Apc4_WD40_dom.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF12894; ANAPC4_WD40; 1.
DR   Pfam; PF00400; WD40; 3.
DR   SMART; SM00320; WD40; 8.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 5.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Angiogenesis; Cell membrane; Cytoplasm; Developmental protein;
KW   Differentiation; Membrane; Phosphoprotein; Reference proteome; Repeat;
KW   WD repeat.
FT   CHAIN           1..435
FT                   /note="Angio-associated migratory cell protein"
FT                   /id="PRO_0000050831"
FT   REPEAT          90..130
FT                   /note="WD 1"
FT   REPEAT          133..172
FT                   /note="WD 2"
FT   REPEAT          174..213
FT                   /note="WD 3"
FT   REPEAT          215..255
FT                   /note="WD 4"
FT   REPEAT          259..300
FT                   /note="WD 5"
FT   REPEAT          316..355
FT                   /note="WD 6"
FT   REPEAT          357..396
FT                   /note="WD 7"
FT   REPEAT          399..434
FT                   /note="WD 8"
FT   REGION          1..65
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        30..65
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         20
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q13685"
SQ   SEQUENCE   435 AA;  46939 MW;  3A66EEF6EB228FB0 CRC64;
     MESESESGAA ADTPPLETLS FHGDEEIIEV VELDPGPPDP DDLAQEMEDV DFEEEEEEEE
     GNEEGWVLEP QEGVVGSMEG PDDSEVTFAL HSASVFCVSL DPKTNTLAVT GGEDDKAFVW
     RLSDGELLFE CAGHKDSVTC AGFSHDSTLV ATGDMSGLLK VWQVDTKEEV WSFEAGDLEW
     MEWHPRAPVL LAGTADGNTW MWKVPNGDCK TFQGPNCPAT CGRVLPDGKR AVVGYEDGTI
     RIWDLKQGSP IHVLKGTEGH QGPLTCVATN QDGSLILTGS VDCQAQLVSA TTGKVVGVFR
     PETVASQPNV GEGEESESNS VESLGFCSVM PLAAVGYLDG TLAIYDLSTQ TLRHQCQHQS
     GIVQLLWEAG TAVVYTCSLD GIVRLWDART GRLLTDYRGH TAEILDFALS KDASLVVTTS
     GDHKAKVFCV QRPDR