RIP19_RALSL
ID RIP19_RALSL Reviewed; 720 AA.
AC Q68A49;
DT 29-OCT-2014, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 25-MAY-2022, entry version 31.
DE RecName: Full=TAL effector protein Rip19 {ECO:0000305};
GN Name=rip19 {ECO:0000303|PubMed:20121447};
GN Synonyms=hpx17 {ECO:0000303|PubMed:15522073};
OS Ralstonia solanacearum (Pseudomonas solanacearum).
OC Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Ralstonia.
OX NCBI_TaxID=305 {ECO:0000312|EMBL:BAD42396.1};
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND INDUCTION BY HRP.
RC STRAIN=RS1000;
RX PubMed=15522073; DOI=10.1111/j.1365-2958.2004.04328.x;
RA Mukaihara T., Tamura N., Murata Y., Iwabuchi M.;
RT "Genetic screening of Hrp type III-related pathogenicity genes controlled
RT by the HrpB transcriptional activator in Ralstonia solanacearum.";
RL Mol. Microbiol. 54:863-875(2004).
RN [2]
RP SUBCELLULAR LOCATION.
RX PubMed=20121447; DOI=10.1094/mpmi-23-3-0251;
RA Mukaihara T., Tamura N., Iwabuchi M.;
RT "Genome-wide identification of a large repertoire of Ralstonia solanacearum
RT type III effector proteins by a new functional screen.";
RL Mol. Plant Microbe Interact. 23:251-262(2010).
RN [3]
RP FUNCTION, SUBCELLULAR LOCATION, DOMAIN, AND REPEAT.
RX PubMed=23692030; DOI=10.1111/nph.12324;
RA de Lange O., Schreiber T., Schandry N., Radeck J., Braun K.H.,
RA Koszinowski J., Heuer H., Strauss A., Lahaye T.;
RT "Breaking the DNA-binding code of Ralstonia solanacearum TAL effectors
RT provides new possibilities to generate plant resistance genes against
RT bacterial wilt disease.";
RL New Phytol. 199:773-786(2013).
CC -!- FUNCTION: Does not activate plant gene transcription, because it has
CC too few core repeats. {ECO:0000303|PubMed:23692030}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P14727}. Host
CC nucleus {ECO:0000269|PubMed:23692030}. Note=Secreted via type III
CC secretion system (TTSS, PubMed:20121447). {ECO:0000269|PubMed:20121447,
CC ECO:0000269|PubMed:23692030}.
CC -!- INDUCTION: By hrpB.
CC -!- DOMAIN: There are at least 4 possible nuclear localization signals,
CC both N- and C-terminal regions contribute to nuclear localization.
CC {ECO:0000269|PubMed:23692030}.
CC -!- SIMILARITY: Belongs to the transcription activator-like effector (TALE)
CC family. RipTAL/RTL subfamily. {ECO:0000305}.
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DR EMBL; AB178011; BAD42396.1; -; Genomic_DNA.
DR AlphaFoldDB; Q68A49; -.
DR SMR; Q68A49; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR InterPro; IPR005042; TAL_effector_rpt.
DR Pfam; PF03377; TAL_effector; 2.
PE 2: Evidence at transcript level;
KW Host nucleus; Repeat; Secreted.
FT CHAIN 1..720
FT /note="TAL effector protein Rip19"
FT /id="PRO_0000430626"
FT REPEAT 286..320
FT /note="Cryptic repeat -1"
FT /evidence="ECO:0000303|PubMed:23692030"
FT REPEAT 321..354
FT /note="Cryptic repeat 0"
FT /evidence="ECO:0000303|PubMed:23692030"
FT REPEAT 355..389
FT /note="Core repeat 1"
FT /evidence="ECO:0000303|PubMed:23692030"
FT REPEAT 390..423
FT /note="Cryptic repeat +1"
FT /evidence="ECO:0000303|PubMed:23692030"
FT REPEAT 424..457
FT /note="Cryptic repeat +2"
FT /evidence="ECO:0000303|PubMed:23692030"
FT REGION 13..85
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 175..205
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 571..611
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 185..191
FT /note="Nuclear localization signal 1"
FT /evidence="ECO:0000303|PubMed:23692030"
FT MOTIF 455..458
FT /note="Nuclear localization signal 2"
FT /evidence="ECO:0000303|PubMed:23692030"
FT MOTIF 583..586
FT /note="Nuclear localization signal 3"
FT /evidence="ECO:0000303|PubMed:23692030"
FT MOTIF 620..623
FT /note="Nuclear localization signal 4"
FT /evidence="ECO:0000303|PubMed:23692030"
FT COMPBIAS 22..42
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 68..85
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 720 AA; 77065 MW; C3D4A2AB5F95E68E CRC64;
MRIGKSSGWL NESVSLEYEH VSPPTRPRDT RRRPRAASDG GLAHLHRRLA VGYAEDTPRT
GARSPAPRRP LPVAPASAPP APSLVPEPPM PVSLPVVSSP RFSAGSSAAI TDPFSSLPPT
PVLYAMAREL KALSDATWQP AVPLPAEPPT DARRGNTVFD EASASSPVIA SACPQAFASP
PRAPRSARAR RARTGGDAWP APTFLSRPSS SRIGRDVFGK LVALGYSREQ IRKLKQESLS
EIAKYHTTLT GQGFTHADIC RISRRRQSLR VVARNYPELA AALPELTRAH IVDIARQRSG
DLALQALLPV ATALTAAPLR LSASQIATVA QYGERPAIQA LYRLRRKLTR APLHLTPQQV
VAIASHDGGK PALEAVWAKL PVLRGVPYAL STAQVVAIAC ISGQQALEAI EAHMPTLRQA
PHSLSPERVA AIACIGGRSA VEAVRQGLPV KAIRRIRREK APVAGPPPAS LGPTPQELVA
VLHFFRAHQQ PRQAFVDALA AFQTTRPALL RLLSSVGVTE IEALGGTIPD ATERWQRLLG
RLGFRPATGA AAPSPDSLQG FAQSLERTLG SPGMAGQSAC SPHRKRPAET AIAPRSIRRR
PNNAGQPSEP WPDQLAWLQR RKRTARSHIR ADSAASVPAN LHLGTRAQFT PDRLRAEPGP
IMQAHTSPAS VSFGSHVAFE PGLPDPGTPT SADLASFEAE PFGVGPLDFH LDWLLQILEA
