ID   RIPL2_BOVIN             Reviewed;         206 AA.
AC   A4IFK7;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=RILP-like protein 2;
DE   AltName: Full=Rab-interacting lysosomal-like protein 2;
GN   Name=RILPL2;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Brain cortex;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in cell shape and neuronal morphogenesis, positively
CC       regulating the establishment and maintenance of dendritic spines. Plays
CC       a role in cellular protein transport, including protein transport away
CC       from primary cilia. May function via activation of RAC1 and PAK1 (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer (By similarity). Interacts with RAC1 (By
CC       similarity). Interacts (via N-terminus) with MYO5A, the interaction is
CC       required for its role in dendrite formation (By similarity). Interacts
CC       with RAB8A; interaction is dependent on the phosphorylation of RAB8A on
CC       'Thr-72' (By similarity). Interacts with RAB10 and RAB12; interaction
CC       is dependent on the phosphorylation of 'Thr-73' on RAB10 and 'Ser-105'
CC       on RAB12 (By similarity). {ECO:0000250|UniProtKB:Q6AYA0,
CC       ECO:0000250|UniProtKB:Q969X0, ECO:0000250|UniProtKB:Q99LE1}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250}. Cytoplasm,
CC       cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}.
CC       Cell projection, cilium {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RILPL family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC134625; AAI34626.1; -; mRNA.
DR   RefSeq; NP_001077187.1; NM_001083718.1.
DR   AlphaFoldDB; A4IFK7; -.
DR   SMR; A4IFK7; -.
DR   STRING; 9913.ENSBTAP00000010264; -.
DR   PaxDb; A4IFK7; -.
DR   PRIDE; A4IFK7; -.
DR   Ensembl; ENSBTAT00000010264; ENSBTAP00000010264; ENSBTAG00000007804.
DR   GeneID; 533228; -.
DR   KEGG; bta:533228; -.
DR   CTD; 196383; -.
DR   VEuPathDB; HostDB:ENSBTAG00000007804; -.
DR   VGNC; VGNC:33968; RILPL2.
DR   eggNOG; ENOG502S08B; Eukaryota.
DR   GeneTree; ENSGT00940000160182; -.
DR   HOGENOM; CLU_096533_1_0_1; -.
DR   InParanoid; A4IFK7; -.
DR   OMA; HRPAMIN; -.
DR   OrthoDB; 890179at2759; -.
DR   TreeFam; TF313489; -.
DR   Proteomes; UP000009136; Chromosome 17.
DR   Bgee; ENSBTAG00000007804; Expressed in blood and 104 other tissues.
DR   GO; GO:0005813; C:centrosome; ISS:UniProtKB.
DR   GO; GO:0036064; C:ciliary basal body; IBA:GO_Central.
DR   GO; GO:0005929; C:cilium; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:GOC.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0060271; P:cilium assembly; IBA:GO_Central.
DR   GO; GO:0003382; P:epithelial cell morphogenesis; ISS:UniProtKB.
DR   GO; GO:1903445; P:protein transport from ciliary membrane to plasma membrane; ISS:UniProtKB.
DR   InterPro; IPR034743; RH1.
DR   InterPro; IPR034744; RH2.
DR   InterPro; IPR021563; RILP_dimer.
DR   Pfam; PF11461; RILP; 1.
DR   PROSITE; PS51776; RH1; 1.
DR   PROSITE; PS51777; RH2; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium; Coiled coil; Cytoplasm; Cytoskeleton;
KW   Protein transport; Reference proteome; Transport.
FT   CHAIN           1..206
FT                   /note="RILP-like protein 2"
FT                   /id="PRO_0000317004"
FT   DOMAIN          19..108
FT                   /note="RH1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01112"
FT   DOMAIN          125..197
FT                   /note="RH2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01113"
FT   REGION          1..29
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          161..189
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          67..159
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        1..19
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   206 AA;  23435 MW;  FE4CA7B18198259C CRC64;
     MEEPPLREEE EEEEEDEAGP EGALGKSPLQ LTAEDVYDIS YVMGRELMAL GSDPRVTQLQ
     FKIVRVLEML ETLVNEGNLT VEELRMERDN LRKEVEGLRR EGSAAGPEVN LGPDKMVVDL
     TDPNRPRFTL QELRDVLQER NKLKSQLLVV QEELQCYKSG LIPPREGPGG RREKEALFPR
     GSNANSNKEE KTIIRKLFSF RSGKQT