RIPP1_MOUSE
ID RIPP1_MOUSE Reviewed; 201 AA.
AC Q2WG77;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 10-JAN-2006, sequence version 1.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Protein ripply1;
GN Name=Ripply1 {ECO:0000312|MGI:MGI:3614797};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000305, ECO:0000312|EMBL:BAE53719.1}
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Embryo {ECO:0000269|PubMed:16326386};
RX PubMed=16326386; DOI=10.1016/j.devcel.2005.09.021;
RA Kawamura A., Koshida S., Hijikata H., Ohbayashi A., Kondoh H., Takada S.;
RT "Groucho-associated transcriptional repressor ripply1 is required for
RT proper transition from the presomitic mesoderm to somites.";
RL Dev. Cell 9:735-744(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- FUNCTION: Plays a role in somitogenesis. Essential for transcriptional
CC repression of the segmental patterning genes, thus terminating the
CC segmentation program in the presomitic mesoderm, and also required for
CC the maintenance of rostrocaudal polarity in somites (By similarity).
CC {ECO:0000250|UniProtKB:Q2WG80}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q2WG80}.
CC -!- TISSUE SPECIFICITY: Expressed in the anterior presomitic mesoderm and
CC somites of stage E9.5 dpc embryos. Also expressed in tongue, diaphragm
CC and intercostal muscles at 16.5 dpc. {ECO:0000269|PubMed:16326386}.
CC -!- DOMAIN: The ripply homology domain is required for transcriptional
CC repression. {ECO:0000250}.
CC -!- DOMAIN: The WRPW motif is required for binding to TLE/GROUCHO proteins.
CC {ECO:0000250|UniProtKB:Q2WG80}.
CC -!- SIMILARITY: Belongs to the ripply family. {ECO:0000305}.
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DR EMBL; AB212222; BAE53719.1; -; mRNA.
DR EMBL; AL672243; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS30436.1; -.
DR RefSeq; NP_001033004.1; NM_001037915.2.
DR AlphaFoldDB; Q2WG77; -.
DR STRING; 10090.ENSMUSP00000098778; -.
DR iPTMnet; Q2WG77; -.
DR PhosphoSitePlus; Q2WG77; -.
DR PaxDb; Q2WG77; -.
DR PRIDE; Q2WG77; -.
DR Antibodypedia; 63924; 12 antibodies from 8 providers.
DR DNASU; 622473; -.
DR Ensembl; ENSMUST00000101217; ENSMUSP00000098778; ENSMUSG00000072945.
DR GeneID; 622473; -.
DR KEGG; mmu:622473; -.
DR UCSC; uc009ukk.2; mouse.
DR CTD; 92129; -.
DR MGI; MGI:3614797; Ripply1.
DR VEuPathDB; HostDB:ENSMUSG00000072945; -.
DR eggNOG; ENOG502S6U6; Eukaryota.
DR GeneTree; ENSGT00940000161952; -.
DR HOGENOM; CLU_117697_0_0_1; -.
DR InParanoid; Q2WG77; -.
DR OMA; ADSEFHH; -.
DR OrthoDB; 1613448at2759; -.
DR PhylomeDB; Q2WG77; -.
DR TreeFam; TF336045; -.
DR BioGRID-ORCS; 622473; 3 hits in 72 CRISPR screens.
DR PRO; PR:Q2WG77; -.
DR Proteomes; UP000000589; Chromosome X.
DR RNAct; Q2WG77; protein.
DR Bgee; ENSMUSG00000072945; Expressed in placenta and 13 other tissues.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0060349; P:bone morphogenesis; IMP:MGI.
DR GO; GO:0009880; P:embryonic pattern specification; ISS:UniProtKB.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
DR GO; GO:0007219; P:Notch signaling pathway; IGI:MGI.
DR GO; GO:0010468; P:regulation of gene expression; IGI:MGI.
DR GO; GO:0032525; P:somite rostral/caudal axis specification; IGI:MGI.
DR GO; GO:0001757; P:somite specification; ISS:UniProtKB.
DR InterPro; IPR028127; Ripply_fam.
DR PANTHER; PTHR16770; PTHR16770; 2.
DR Pfam; PF14998; Ripply; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; Nucleus; Reference proteome; Repressor;
KW Transcription; Transcription regulation.
FT CHAIN 1..201
FT /note="Protein ripply1"
FT /id="PRO_0000307757"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 99..134
FT /note="Ripply homology domain"
FT /evidence="ECO:0000255"
FT REGION 136..201
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 57..60
FT /note="WRPW motif"
FT /evidence="ECO:0000255"
FT COMPBIAS 1..18
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 137..171
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 201 AA; 21804 MW; B2E326765147FA65 CRC64;
MDPAASPAAA PPAAPAAAPA ADPAADPAAA LPGQALAQAP ALAQINGQEG ARNERAAYLW
RPWLSSINDQ PRQARSLVDW ADNRATAAEA AKTDSDFHHP VRLYWPKSHS FDYLYSAGEI
LLNNFPVQAT INLYEDSDSA DNEEDKEEEE EEEEEEDDEE EEEDEDKDVN ENEPEVCMGV
SEATTHKATA HSPDPHSACP N
