ID   RIPP2_DANRE             Reviewed;         109 AA.
AC   Q2WG79; A2BHT0;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-OCT-2007, sequence version 2.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Protein ripply2;
GN   Name=ripply2 {ECO:0000312|ZFIN:ZDB-GENE-060113-2};
GN   ORFNames=si:ch211-152c2.8;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:BAE53717.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   TISSUE=Embryo {ECO:0000269|PubMed:16326386};
RX   PubMed=16326386; DOI=10.1016/j.devcel.2005.09.021;
RA   Kawamura A., Koshida S., Hijikata H., Ohbayashi A., Kondoh H., Takada S.;
RT   "Groucho-associated transcriptional repressor ripply1 is required for
RT   proper transition from the presomitic mesoderm to somites.";
RL   Dev. Cell 9:735-744(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
CC   -!- FUNCTION: Plays a role in somitogenesis. Required for somite
CC       segregation and establishment of rostrocaudal polarity in somites (By
CC       similarity). {ECO:0000250|UniProtKB:Q2WG76}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q2WG80}.
CC   -!- TISSUE SPECIFICITY: First expressed in the paraxial mesoderm at the 90%
CC       epiboly stage, and subsequently confined to the presomitic mesoderm.
CC       Expressed in the rostral compartment of S-I and S-II.
CC       {ECO:0000269|PubMed:16326386}.
CC   -!- DOMAIN: The ripply homology domain is required for transcriptional
CC       repression. {ECO:0000250}.
CC   -!- DOMAIN: The WRPW motif is required for binding to tle/groucho proteins.
CC       {ECO:0000250|UniProtKB:Q2WG80}.
CC   -!- SIMILARITY: Belongs to the ripply family. {ECO:0000305}.
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DR   EMBL; AB212220; BAE53717.1; -; mRNA.
DR   EMBL; BX649468; CAM13289.1; -; Genomic_DNA.
DR   RefSeq; NP_001034198.1; NM_001039109.1.
DR   AlphaFoldDB; Q2WG79; -.
DR   STRING; 7955.ENSDARP00000094407; -.
DR   PaxDb; Q2WG79; -.
DR   Ensembl; ENSDART00000103631; ENSDARP00000094407; ENSDARG00000070535.
DR   GeneID; 654447; -.
DR   KEGG; dre:654447; -.
DR   CTD; 134701; -.
DR   ZFIN; ZDB-GENE-060113-2; ripply2.
DR   eggNOG; ENOG502S6U6; Eukaryota.
DR   GeneTree; ENSGT00940000161952; -.
DR   HOGENOM; CLU_117697_2_0_1; -.
DR   InParanoid; Q2WG79; -.
DR   OMA; EMDANQP; -.
DR   OrthoDB; 1552301at2759; -.
DR   PhylomeDB; Q2WG79; -.
DR   TreeFam; TF336045; -.
DR   PRO; PR:Q2WG79; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 4.
DR   Bgee; ENSDARG00000070535; Expressed in testis and 18 other tissues.
DR   ExpressionAtlas; Q2WG79; baseline.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0009880; P:embryonic pattern specification; IBA:GO_Central.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0032525; P:somite rostral/caudal axis specification; ISS:UniProtKB.
DR   GO; GO:0001756; P:somitogenesis; ISS:UniProtKB.
DR   InterPro; IPR028127; Ripply_fam.
DR   PANTHER; PTHR16770; PTHR16770; 1.
DR   Pfam; PF14998; Ripply; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; Nucleus; Reference proteome.
FT   CHAIN           1..109
FT                   /note="Protein ripply2"
FT                   /id="PRO_0000307761"
FT   REGION          1..42
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          53..88
FT                   /note="Ripply homology domain"
FT                   /evidence="ECO:0000255"
FT   REGION          88..109
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           20..23
FT                   /note="WRPW motif"
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        1..25
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        89..109
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        41
FT                   /note="A -> V (in Ref. 1; BAE53717)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   109 AA;  13070 MW;  5267E50B2A90360A CRC64;
     MENITFTSGL NSEMDANQPW RPWLSQTSRK APDYKPYKRP ADDEQHKLSI FKHPVKLFWP
     KSQCFDYLYE DAEVLLRNYP VQATICLYED PDTEDEEDYS DEEDEKELR