RIPP2_MOUSE
ID RIPP2_MOUSE Reviewed; 128 AA.
AC Q2WG76; Q8BNN5;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 10-JAN-2006, sequence version 1.
DT 03-AUG-2022, entry version 85.
DE RecName: Full=Protein ripply2;
GN Name=Ripply2 {ECO:0000312|MGI:MGI:2685968};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000305, ECO:0000312|EMBL:BAE53720.1}
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Embryo {ECO:0000269|PubMed:16326386};
RX PubMed=16326386; DOI=10.1016/j.devcel.2005.09.021;
RA Kawamura A., Koshida S., Hijikata H., Ohbayashi A., Kondoh H., Takada S.;
RT "Groucho-associated transcriptional repressor ripply1 is required for
RT proper transition from the presomitic mesoderm to somites.";
RL Dev. Cell 9:735-744(2005).
RN [2] {ECO:0000305, ECO:0000312|EMBL:BAC38162.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 30-128.
RC STRAIN=C57BL/6J {ECO:0000312|EMBL:BAC38162.1};
RC TISSUE=Corpus striatum {ECO:0000312|EMBL:BAC38162.1};
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3] {ECO:0000305}
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=17531978; DOI=10.1016/j.febslet.2007.05.017;
RA Chan T., Kondow A., Hosoya A., Hitachi K., Yukita A., Okabayashi K.,
RA Nakamura H., Ozawa H., Kiyonari H., Michiue T., Ito Y., Asashima M.;
RT "Ripply2 is essential for precise somite formation during mouse early
RT development.";
RL FEBS Lett. 581:2691-2696(2007).
RN [4] {ECO:0000305}
RP FUNCTION, AND INDUCTION.
RX PubMed=17360776; DOI=10.1242/dev.000836;
RA Morimoto M., Sasaki N., Oginuma M., Kiso M., Igarashi K., Aizaki K.,
RA Kanno J., Saga Y.;
RT "The negative regulation of Mesp2 by mouse Ripply2 is required to establish
RT the rostro-caudal patterning within a somite.";
RL Development 134:1561-1569(2007).
CC -!- FUNCTION: Plays a role in somitogenesis. Required for somite
CC segregation and establishment of rostrocaudal polarity in somites.
CC {ECO:0000269|PubMed:17360776, ECO:0000269|PubMed:17531978}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q2WG80}.
CC -!- TISSUE SPECIFICITY: Expressed in the embryonic anterior presomitic
CC mesoderm. First expressed in S-I at 8.5 dpc, where expression is
CC maintained until 13.5 dpc, with an additional stripe of expression
CC sometimes seen in the rostral part of S0 and S-I.
CC {ECO:0000269|PubMed:16326386, ECO:0000269|PubMed:17531978}.
CC -!- INDUCTION: By MESP2, and acts in a negative feedback loop with MESP2,
CC functioning negatively toward MESP2 to regulate NOTCH signaling in the
CC anterior presomitic mesoderm. {ECO:0000269|PubMed:17360776}.
CC -!- DOMAIN: The ripply homology domain is required for transcriptional
CC repression. {ECO:0000250}.
CC -!- DOMAIN: The WRPW motif is required for binding to tle/groucho proteins.
CC {ECO:0000250|UniProtKB:Q2WG80}.
CC -!- SIMILARITY: Belongs to the ripply family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC38162.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};
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DR EMBL; AB212223; BAE53720.1; -; mRNA.
DR EMBL; AK081203; BAC38162.1; ALT_SEQ; mRNA.
DR CCDS; CCDS40715.1; -.
DR RefSeq; NP_001032996.1; NM_001037907.1.
DR AlphaFoldDB; Q2WG76; -.
DR STRING; 10090.ENSMUSP00000055369; -.
DR PaxDb; Q2WG76; -.
DR PRIDE; Q2WG76; -.
DR Antibodypedia; 57637; 63 antibodies from 10 providers.
DR DNASU; 382089; -.
DR Ensembl; ENSMUST00000058846; ENSMUSP00000055369; ENSMUSG00000047897.
DR GeneID; 382089; -.
DR KEGG; mmu:382089; -.
DR UCSC; uc009qya.1; mouse.
DR CTD; 134701; -.
DR MGI; MGI:2685968; Ripply2.
DR VEuPathDB; HostDB:ENSMUSG00000047897; -.
DR eggNOG; ENOG502S6U6; Eukaryota.
DR GeneTree; ENSGT00940000161538; -.
DR HOGENOM; CLU_117697_1_0_1; -.
DR InParanoid; Q2WG76; -.
DR OMA; LWRPWNK; -.
DR OrthoDB; 1552301at2759; -.
DR PhylomeDB; Q2WG76; -.
DR TreeFam; TF336045; -.
DR BioGRID-ORCS; 382089; 1 hit in 71 CRISPR screens.
DR PRO; PR:Q2WG76; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q2WG76; protein.
DR Bgee; ENSMUSG00000047897; Expressed in lumbar subsegment of spinal cord and 78 other tissues.
DR Genevisible; Q2WG76; MM.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0009798; P:axis specification; IMP:MGI.
DR GO; GO:0060349; P:bone morphogenesis; IGI:MGI.
DR GO; GO:0007368; P:determination of left/right symmetry; IMP:MGI.
DR GO; GO:0009880; P:embryonic pattern specification; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0007219; P:Notch signaling pathway; IGI:MGI.
DR GO; GO:0001503; P:ossification; IMP:MGI.
DR GO; GO:0036342; P:post-anal tail morphogenesis; IMP:MGI.
DR GO; GO:0010468; P:regulation of gene expression; IGI:MGI.
DR GO; GO:0032525; P:somite rostral/caudal axis specification; IDA:UniProtKB.
DR GO; GO:0001756; P:somitogenesis; IDA:UniProtKB.
DR InterPro; IPR028127; Ripply_fam.
DR PANTHER; PTHR16770; PTHR16770; 1.
DR Pfam; PF14998; Ripply; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; Nucleus; Reference proteome.
FT CHAIN 1..128
FT /note="Protein ripply2"
FT /id="PRO_0000307760"
FT REGION 1..64
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 74..109
FT /note="Ripply homology domain"
FT /evidence="ECO:0000255"
FT MOTIF 34..37
FT /note="WRPW motif"
FT /evidence="ECO:0000255"
SQ SEQUENCE 128 AA; 14305 MW; 4B9FFB58B5499506 CRC64;
MDTTESAESA HNPARPPSRS RCPPSAQPGS EGFWRPWVRT PGEKEKRTGP RAAEALPSGP
GMAEASGKLL QYQHPVRLFW PKSKCYDYLY QEAETLLKNF PIQATISFYE DSDSEDEIEG
LACENQSN
