ID   RIPP_BRABE              Reviewed;         154 AA.
AC   Q5I2D0;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   25-MAY-2022, entry version 21.
DE   RecName: Full=Protein ripply;
DE   AltName: Full=Protein AmphiSom;
GN   Name=RIPPLY {ECO:0000303|PubMed:16326386};
GN   Synonyms=AmphiSom {ECO:0000303|PubMed:16211387};
OS   Branchiostoma belcheri (Amphioxus).
OC   Eukaryota; Metazoa; Chordata; Cephalochordata; Leptocardii; Amphioxiformes;
OC   Branchiostomidae; Branchiostoma.
OX   NCBI_TaxID=7741;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:AAW52554.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RC   TISSUE=Neurula {ECO:0000269|PubMed:16211387};
RX   PubMed=16211387; DOI=10.1007/s00427-005-0027-6;
RA   Li X., Zhang W., Chen D., Lin Y., Huang X., Shi D., Zhang H.;
RT   "Expression of a novel somite-formation-related gene, AmphiSom, during
RT   amphioxus development.";
RL   Dev. Genes Evol. 216:52-55(2006).
RN   [2] {ECO:0000305}
RP   IDENTIFICATION AS RIPPLY.
RX   PubMed=16326386; DOI=10.1016/j.devcel.2005.09.021;
RA   Kawamura A., Koshida S., Hijikata H., Ohbayashi A., Kondoh H., Takada S.;
RT   "Groucho-associated transcriptional repressor ripply1 is required for
RT   proper transition from the presomitic mesoderm to somites.";
RL   Dev. Cell 9:735-744(2005).
CC   -!- FUNCTION: May play a role in somitogenesis.
CC       {ECO:0000269|PubMed:16211387}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q2WG80}.
CC   -!- TISSUE SPECIFICITY: In the late gastrula stage, expression appears in
CC       the dorsal presomitic mesoderm and in the first three pairs of nascent
CC       somites. Expressed strongly in forming somites and then expression is
CC       rapidly down-regulated except in the first somite pair where expression
CC       is maintained for a longer period. Also expressed in the presumptive
CC       notochord and in the tail bud at the 48 hour larval stage. Expression
CC       disappears by the 72 hour stage. {ECO:0000269|PubMed:16211387}.
CC   -!- DOMAIN: The ripply homology domain is required for transcriptional
CC       repression. {ECO:0000250}.
CC   -!- DOMAIN: The WRPW motif is required for binding to TLE/GROUCHO proteins.
CC       {ECO:0000250|UniProtKB:Q2WG80}.
CC   -!- SIMILARITY: Belongs to the ripply family. {ECO:0000305}.
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DR   EMBL; AY860953; AAW52554.1; -; mRNA.
DR   AlphaFoldDB; Q5I2D0; -.
DR   Proteomes; UP000515135; Unplaced.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0001756; P:somitogenesis; IMP:UniProtKB.
DR   InterPro; IPR028127; Ripply_fam.
DR   PANTHER; PTHR16770; PTHR16770; 1.
DR   Pfam; PF14998; Ripply; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; Nucleus; Reference proteome.
FT   CHAIN           1..154
FT                   /note="Protein ripply"
FT                   /id="PRO_0000307762"
FT   REGION          54..86
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          85..119
FT                   /note="Ripply homology domain"
FT                   /evidence="ECO:0000255"
FT   REGION          121..154
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           38..41
FT                   /note="WRPW motif"
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        63..79
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        123..139
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   154 AA;  17611 MW;  3212E07037E12693 CRC64;
     MEATRFTFNT ATLCSAQHCN CHKLTTKASG MPVQPPVWRP WIVTERDILR RNAIRERRSK
     PYARPSSTSN GSTRGPEPGP TSFQHPVKLH WSKPVYDYMY QYGKQLLDAF PVQATICIVD
     EDPAQSDDSD FESDYEDDSD TDYKPLKRNA PILN