RIPR3_HUMAN
ID RIPR3_HUMAN Reviewed; 946 AA.
AC Q96MK2; Q5QPB6; Q9NQQ2;
DT 30-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT 10-JUL-2007, sequence version 4.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=RIPOR family member 3 {ECO:0000312|HGNC:HGNC:16168};
GN Name=RIPOR3 {ECO:0000312|HGNC:HGNC:16168};
GN Synonyms=C20orf175 {ECO:0000312|HGNC:HGNC:16168},
GN C20orf176 {ECO:0000312|HGNC:HGNC:16168},
GN FAM65C {ECO:0000312|HGNC:HGNC:16168};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANT PRO-580.
RC TISSUE=Placenta;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11780052; DOI=10.1038/414865a;
RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 20.";
RL Nature 414:865-871(2001).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-9; SER-24; SER-340; THR-345
RP AND SER-384, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE
RP ANALYSIS].
RC TISSUE=Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- INTERACTION:
CC Q96MK2; Q86Z20: CCDC125; NbExp=3; IntAct=EBI-12010512, EBI-11977221;
CC Q96MK2; P61586: RHOA; NbExp=3; IntAct=EBI-12010512, EBI-446668;
CC Q96MK2; P08134: RHOC; NbExp=3; IntAct=EBI-12010512, EBI-747589;
CC Q96MK2; Q8N228-3: SCML4; NbExp=3; IntAct=EBI-12010512, EBI-17182094;
CC Q96MK2; Q9UPX8-4: SHANK2; NbExp=3; IntAct=EBI-12010512, EBI-11959011;
CC Q96MK2; Q13077: TRAF1; NbExp=3; IntAct=EBI-12010512, EBI-359224;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q96MK2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96MK2-2; Sequence=VSP_026496;
CC -!- SIMILARITY: Belongs to the RIPOR family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK056792; BAB71286.1; -; mRNA.
DR EMBL; AL133230; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS13431.2; -. [Q96MK2-1]
DR RefSeq; NP_543019.2; NM_080829.3. [Q96MK2-1]
DR RefSeq; XP_011526881.1; XM_011528579.2. [Q96MK2-1]
DR RefSeq; XP_011526882.1; XM_011528580.2. [Q96MK2-1]
DR RefSeq; XP_011526883.1; XM_011528581.2. [Q96MK2-1]
DR AlphaFoldDB; Q96MK2; -.
DR SMR; Q96MK2; -.
DR BioGRID; 126746; 10.
DR IntAct; Q96MK2; 6.
DR STRING; 9606.ENSP00000332663; -.
DR iPTMnet; Q96MK2; -.
DR PhosphoSitePlus; Q96MK2; -.
DR BioMuta; RIPOR3; -.
DR DMDM; 152031578; -.
DR jPOST; Q96MK2; -.
DR MassIVE; Q96MK2; -.
DR PaxDb; Q96MK2; -.
DR PeptideAtlas; Q96MK2; -.
DR PRIDE; Q96MK2; -.
DR ProteomicsDB; 77368; -. [Q96MK2-1]
DR ProteomicsDB; 77369; -. [Q96MK2-2]
DR Antibodypedia; 66212; 62 antibodies from 14 providers.
DR DNASU; 140876; -.
DR Ensembl; ENST00000045083.6; ENSP00000045083.2; ENSG00000042062.13. [Q96MK2-1]
DR GeneID; 140876; -.
DR KEGG; hsa:140876; -.
DR UCSC; uc002xvm.4; human. [Q96MK2-1]
DR CTD; 140876; -.
DR DisGeNET; 140876; -.
DR GeneCards; RIPOR3; -.
DR HGNC; HGNC:16168; RIPOR3.
DR HPA; ENSG00000042062; Low tissue specificity.
DR neXtProt; NX_Q96MK2; -.
DR OpenTargets; ENSG00000042062; -.
DR PharmGKB; PA162387710; -.
DR VEuPathDB; HostDB:ENSG00000042062; -.
DR eggNOG; ENOG502QY15; Eukaryota.
DR GeneTree; ENSGT00940000153717; -.
DR HOGENOM; CLU_006211_1_0_1; -.
DR InParanoid; Q96MK2; -.
DR OMA; ELDYLCG; -.
DR OrthoDB; 1121546at2759; -.
DR PhylomeDB; Q96MK2; -.
DR TreeFam; TF329332; -.
DR PathwayCommons; Q96MK2; -.
DR SignaLink; Q96MK2; -.
DR BioGRID-ORCS; 140876; 10 hits in 1079 CRISPR screens.
DR ChiTaRS; FAM65C; human.
DR GenomeRNAi; 140876; -.
DR Pharos; Q96MK2; Tdark.
DR PRO; PR:Q96MK2; -.
DR Proteomes; UP000005640; Chromosome 20.
DR RNAct; Q96MK2; protein.
DR Bgee; ENSG00000042062; Expressed in endocervix and 122 other tissues.
DR ExpressionAtlas; Q96MK2; baseline and differential.
DR Genevisible; Q96MK2; HS.
DR InterPro; IPR031780; FAM65_N.
DR InterPro; IPR026136; RIPOR3.
DR PANTHER; PTHR15829; PTHR15829; 1.
DR Pfam; PF15903; PL48; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Phosphoprotein; Reference proteome.
FT CHAIN 1..946
FT /note="RIPOR family member 3"
FT /id="PRO_0000079484"
FT REGION 390..512
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 390..404
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 412..426
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 476..498
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 9
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 24
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 340
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 345
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 351
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:A1L3T7"
FT MOD_RES 384
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT VAR_SEQ 594..946
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_026496"
FT VARIANT 566
FT /note="C -> S (in dbSNP:rs35965508)"
FT /id="VAR_062194"
FT VARIANT 580
FT /note="L -> P (in dbSNP:rs6020624)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_053914"
FT CONFLICT 557
FT /note="H -> L (in Ref. 1; BAB71286)"
FT /evidence="ECO:0000305"
FT CONFLICT 564
FT /note="M -> I (in Ref. 1; BAB71286)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 946 AA; 105290 MW; 4130C51B865B01F4 CRC64;
MSVRLRFLSP GDTGAVGVVG RSASFAGFSS AQSRRIAKSI NRNSVRSRMP AKSSKMYGTL
RKGSVCADPK PQQVKKIFEA LKRGLKEYLC VQQAELDHLS GRHKDTRRNS RLAFYYDLDK
QTRCVERHIR KMEFHISKVD ELYEDYCIQC RLRDGASSMQ RAFARCPPSR AARESLQELG
RSLHECAEDM WLIEGALEVH LGEFHIRMKG LVGYARLCPG DHYEVLMRLG RQRWKLKGRI
ESDDSQTWDE EEKAFIPTLH ENLDIKVTEL RGLGSLAVGA VTCDIADFFT TRPQVIVVDI
TELGTIKLQL EVQWNPFDTE SFLVSPSPTG KFSMGSRKGS LYNWTPPSTP SFRERYYLSV
LQQPTQQALL LGGPRATSIL SYLSDSDLRG PSLRSQSQEL PEMDSFSSED PRDTETSTSA
STSDVGFLPL TFGPHASIEE EAREDPLPPG LLPEMAHLSG GPFAEQPGWR NLGGESPSLP
QGSLFHSGTA SSSQNGHEEG ATGDREDGPG VALEGPLQEV LELLRPTDST QPQLRELEYQ
VLGFRDRLKP CRARQEHTSA ESLMECILES FAFLNADFAL DELSLFGGSQ GLRKDRPLPP
PSSLKASSRE LTAGAPELDV LLMVHLQVCK ALLQKLASPN LSRLVQECLL EEVAQQKHVL
ETLSVLDFEK VGKATSIEEI IPQASRTKGC LKLWRGCTGP GRVLSCPATT LLNQLKKTFQ
HRVRGKYPGQ LEIACRRLLE QVVSCGGLLP GAGLPEEQII TWFQFHSYLQ RQSVSDLEKH
FTQLTKEVTL IEELHCAGQA KVVRKLQGKR LGQLQPLPQT LRAWALLQLD GTPRVCRAAS
ARLAGAVRNR SFREKALLFY TNALAENDAR LQQAACLALK HLKGIESIDQ TASLCQSDLE
AVRAAARETT LSFGEKGRLA FEKMDKLCSE QREVFCQEAD VEITIF
