ID   RIPX_CUCPE              Reviewed;          20 AA.
AC   P80750;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   25-MAY-2022, entry version 53.
DE   RecName: Full=Ribosome-inactivating protein;
DE            EC=3.2.2.22;
DE   AltName: Full=rRNA N-glycosidase;
DE   Flags: Fragment;
OS   Cucurbita pepo (Vegetable marrow) (Summer squash).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Cucurbitales; Cucurbitaceae; Cucurbiteae; Cucurbita.
OX   NCBI_TaxID=3663;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Mesocarp;
RX   PubMed=9022685; DOI=10.1111/j.1432-1033.1996.0585r.x;
RA   Yoshinari S., Yokota S., Sawmoto H., Koresawa S., Tamura M., Endo Y.;
RT   "Purification, characterization and subcellular localization of a type-1
RT   ribosome-inactivating protein from the sarcocarp of Cucurbita pepo.";
RL   Eur. J. Biochem. 242:585-591(1996).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Endohydrolysis of the N-glycosidic bond at one specific
CC         adenosine on the 28S rRNA.; EC=3.2.2.22;
CC   -!- SIMILARITY: Belongs to the ribosome-inactivating protein family. Type 1
CC       RIP subfamily. {ECO:0000305}.
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DR   AlphaFoldDB; P80750; -.
DR   GO; GO:0030598; F:rRNA N-glycosylase activity; IEA:UniProtKB-EC.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR   GO; GO:0017148; P:negative regulation of translation; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Hydrolase; Plant defense;
KW   Protein synthesis inhibitor; Toxin.
FT   CHAIN           1..>20
FT                   /note="Ribosome-inactivating protein"
FT                   /id="PRO_0000221399"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         20
SQ   SEQUENCE   20 AA;  2235 MW;  8E753D217FDEAA6D CRC64;
     NVRFDLSGAT SSSYKTFIKN