ID   RIP_DROME               Reviewed;         197 AA.
AC   Q9VL31; Q4PKP8;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 113.
DE   RecName: Full=RIP-like protein;
DE   AltName: Full=RIP-alpha;
GN   Name=Ripalpha; ORFNames=CG18145;
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Testis;
RX   PubMed=15917496; DOI=10.1093/molbev/msi175;
RA   Jagadeeshan S., Singh R.S.;
RT   "Rapidly evolving genes of Drosophila: differing levels of selective
RT   pressure in testis, ovary, and head tissues between sibling species.";
RL   Mol. Biol. Evol. 22:1793-1801(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=W1118;
RA   Park J., Kim K., Lee J.H.;
RT   "Cloning of Drosophila RIPalpha.";
RL   Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley;
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA   Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA   Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA   An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA   Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA   Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA   Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA   Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA   Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA   Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA   Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA   Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA   Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA   Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA   Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA   Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA   Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA   McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA   Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA   Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA   Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA   Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA   Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA   Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA   Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA   Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA   Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA   Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA   Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [4]
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley;
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA   Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT   review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Berkeley; TISSUE=Embryo;
RX   PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA   Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA   Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA   Celniker S.E.;
RT   "A Drosophila full-length cDNA resource.";
RL   Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
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DR   EMBL; DQ062806; AAY56679.1; -; mRNA.
DR   EMBL; DQ072161; AAY82588.1; -; mRNA.
DR   EMBL; AE014134; AAF52867.1; -; Genomic_DNA.
DR   EMBL; AY089598; AAL90336.1; -; mRNA.
DR   RefSeq; NP_609351.1; NM_135507.3.
DR   AlphaFoldDB; Q9VL31; -.
DR   SMR; Q9VL31; -.
DR   BioGRID; 60442; 2.
DR   IntAct; Q9VL31; 1.
DR   PaxDb; Q9VL31; -.
DR   DNASU; 34351; -.
DR   EnsemblMetazoa; FBtr0079962; FBpp0079552; FBgn0032189.
DR   GeneID; 34351; -.
DR   KEGG; dme:Dmel_CG18145; -.
DR   CTD; 34351; -.
DR   FlyBase; FBgn0032189; Ripalpha.
DR   VEuPathDB; VectorBase:FBgn0032189; -.
DR   eggNOG; ENOG502TA4P; Eukaryota.
DR   GeneTree; ENSGT00390000006416; -.
DR   HOGENOM; CLU_1373525_0_0_1; -.
DR   InParanoid; Q9VL31; -.
DR   OMA; QKRHAQD; -.
DR   OrthoDB; 1518754at2759; -.
DR   PhylomeDB; Q9VL31; -.
DR   BioGRID-ORCS; 34351; 1 hit in 1 CRISPR screen.
DR   GenomeRNAi; 34351; -.
DR   PRO; PR:Q9VL31; -.
DR   Proteomes; UP000000803; Chromosome 2L.
DR   Bgee; FBgn0032189; Expressed in egg cell and 25 other tissues.
DR   Genevisible; Q9VL31; DM.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006606; P:protein import into nucleus; IBA:GO_Central.
DR   InterPro; IPR028156; RIP.
DR   InterPro; IPR028159; RPA_interact_C_dom.
DR   PANTHER; PTHR31742; PTHR31742; 1.
DR   Pfam; PF14768; RPA_interact_C; 1.
PE   2: Evidence at transcript level;
KW   Metal-binding; Reference proteome; Zinc; Zinc-finger.
FT   CHAIN           1..197
FT                   /note="RIP-like protein"
FT                   /id="PRO_0000076304"
FT   ZN_FING         122..191
FT                   /note="RIP-type"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   197 AA;  23252 MW;  37F638FFD83AB1A8 CRC64;
     MNSTQSPVYR TSVEQKRHAQ EVAKRQRMGN QMPRLREMLR EKYRKRIIET RNRCTDAQRE
     IQLSELREIL RLELSELEKD VELEELILEE LLSDVNEWYA LGEKNLETLY AEPDEQQKEV
     LCPVCQIKNL RHHKGAFICE CGIRFEHSAN MEQLQILLQQ QIASHELQCT QALRFFIEPA
     SGQLYDMCGS CDYFSSV