ID   RIP_SIRGR               Reviewed;          18 AA.
AC   P83323;
DT   02-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT   02-MAY-2002, sequence version 1.
DT   25-MAY-2022, entry version 43.
DE   RecName: Full=Ribosome-inactivating protein momorgrosvin;
DE            EC=3.2.2.22;
DE   AltName: Full=rRNA N-glycosidase;
DE   Flags: Fragment;
OS   Siraitia grosvenorii (Monk's fruit) (Luo han guo).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Cucurbitales; Cucurbitaceae; Siraitieae; Siraitia.
OX   NCBI_TaxID=190515;
RN   [1]
RP   PROTEIN SEQUENCE, FUNCTION, AND GLYCOSYLATION.
RC   TISSUE=Seed;
RX   PubMed=11205869; DOI=10.1016/s0024-3205(00)00980-2;
RA   Tsang K.Y., Ng T.B.;
RT   "Isolation and characterization of a new ribosome inactivating protein,
RT   momorgrosvin, from seeds of the monk's fruit Momordica grosvenorii.";
RL   Life Sci. 68:773-784(2001).
CC   -!- FUNCTION: Inhibits protein synthesis in the rabbit reticulocyte lysate
CC       system. {ECO:0000269|PubMed:11205869}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Endohydrolysis of the N-glycosidic bond at one specific
CC         adenosine on the 28S rRNA.; EC=3.2.2.22;
CC   -!- PTM: Glycosylated. {ECO:0000269|PubMed:11205869}.
CC   -!- SIMILARITY: Belongs to the ribosome-inactivating protein family. Type 1
CC       RIP subfamily. {ECO:0000305}.
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DR   AlphaFoldDB; P83323; -.
DR   GO; GO:0030598; F:rRNA N-glycosylase activity; IDA:UniProtKB.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR   GO; GO:0017148; P:negative regulation of translation; IDA:UniProtKB.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Glycoprotein; Hydrolase; Plant defense;
KW   Protein synthesis inhibitor; Toxin.
FT   CHAIN           1..>18
FT                   /note="Ribosome-inactivating protein momorgrosvin"
FT                   /id="PRO_0000221407"
FT   NON_TER         18
SQ   SEQUENCE   18 AA;  2032 MW;  476E15CE683E2446 CRC64;
     DVTFSMLGAN GATYYQFF