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AAMP_PONAB
ID   AAMP_PONAB              Reviewed;         434 AA.
AC   Q5RCG7; Q5RA18;
DT   26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 2.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=Angio-associated migratory cell protein;
GN   Name=AAMP;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex, and Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a role in angiogenesis and cell migration. In smooth
CC       muscle cell migration, may act through the RhoA pathway (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}. Cytoplasm
CC       {ECO:0000250}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAH91392.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; CR858303; CAH90540.1; -; mRNA.
DR   EMBL; CR859206; CAH91392.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001125288.1; NM_001131816.1.
DR   AlphaFoldDB; Q5RCG7; -.
DR   SMR; Q5RCG7; -.
DR   STRING; 9601.ENSPPYP00000014710; -.
DR   Ensembl; ENSPPYT00000015307; ENSPPYP00000014710; ENSPPYG00000013166.
DR   GeneID; 100172186; -.
DR   KEGG; pon:100172186; -.
DR   CTD; 14; -.
DR   eggNOG; KOG0296; Eukaryota.
DR   GeneTree; ENSGT00940000153648; -.
DR   HOGENOM; CLU_000288_57_9_1; -.
DR   InParanoid; Q5RCG7; -.
DR   OMA; WMWKVPS; -.
DR   TreeFam; TF314543; -.
DR   Proteomes; UP000001595; Chromosome 2B.
DR   GO; GO:0009986; C:cell surface; ISS:UniProtKB.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0045171; C:intercellular bridge; IEA:Ensembl.
DR   GO; GO:0015630; C:microtubule cytoskeleton; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008201; F:heparin binding; IEA:Ensembl.
DR   GO; GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0010595; P:positive regulation of endothelial cell migration; ISS:UniProtKB.
DR   GO; GO:0014909; P:smooth muscle cell migration; ISS:UniProtKB.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00400; WD40; 5.
DR   SMART; SM00320; WD40; 8.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 6.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Angiogenesis; Cell membrane; Cytoplasm; Developmental protein;
KW   Differentiation; Membrane; Phosphoprotein; Reference proteome; Repeat;
KW   WD repeat.
FT   CHAIN           1..434
FT                   /note="Angio-associated migratory cell protein"
FT                   /id="PRO_0000050833"
FT   REPEAT          89..129
FT                   /note="WD 1"
FT   REPEAT          132..171
FT                   /note="WD 2"
FT   REPEAT          173..212
FT                   /note="WD 3"
FT   REPEAT          214..254
FT                   /note="WD 4"
FT   REPEAT          258..299
FT                   /note="WD 5"
FT   REPEAT          315..354
FT                   /note="WD 6"
FT   REPEAT          356..395
FT                   /note="WD 7"
FT   REPEAT          398..433
FT                   /note="WD 8"
FT   REGION          1..63
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        30..63
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         20
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q13685"
FT   CONFLICT        86
FT                   /note="T -> I (in Ref. 1; CAH90540)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        125
FT                   /note="E -> G (in Ref. 1; CAH90540)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        193..194
FT                   /note="TA -> H (in Ref. 1; CAH90540)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   434 AA;  46781 MW;  16B3815553EBA3B2 CRC64;
     MESESESGAA ADTPPLETLS FHGDEEIIEV VELDPGPPDP DDLAQEMEDV DFEEEEEEEG
     NEEGWVLEPQ EGVVGSMEGP DDSEVTFALH SASVFCVSLD PKTNTLAVTG GEDDKAFVWR
     LSDGELLFEC AGHKDSVTCA GFSHDSTLVA TGDMSGLLKV WQVDTKEEVW SFEAGDLEWM
     EWHPRAPVLL AGTADGNTWM WKVPNGDCKT FQGPNCPATC GRVLPDGKRA VVGYEDGTIR
     IWDLKQGSPI HVLKGTEGHQ GPLTCVATNQ DGSLILTGSV DCQAKLVSAT TGKVVGVFRP
     ETVASQPSLG EGEESESNSV ESLGFCSVMP LAAVGYLDGT LAIYDLATQT LRHQCQHQSG
     IVQLLWEAGT AVVYTCSLDG IVRLWDARTG RLLTDYRGHT AEILDFALSK DASLVVTTSG
     DHKAKVFCVQ RPDR
 
 
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