AAMP_PONAB
ID AAMP_PONAB Reviewed; 434 AA.
AC Q5RCG7; Q5RA18;
DT 26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2005, sequence version 2.
DT 03-AUG-2022, entry version 93.
DE RecName: Full=Angio-associated migratory cell protein;
GN Name=AAMP;
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain cortex, and Kidney;
RG The German cDNA consortium;
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Plays a role in angiogenesis and cell migration. In smooth
CC muscle cell migration, may act through the RhoA pathway (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}. Cytoplasm
CC {ECO:0000250}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAH91392.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; CR858303; CAH90540.1; -; mRNA.
DR EMBL; CR859206; CAH91392.1; ALT_INIT; mRNA.
DR RefSeq; NP_001125288.1; NM_001131816.1.
DR AlphaFoldDB; Q5RCG7; -.
DR SMR; Q5RCG7; -.
DR STRING; 9601.ENSPPYP00000014710; -.
DR Ensembl; ENSPPYT00000015307; ENSPPYP00000014710; ENSPPYG00000013166.
DR GeneID; 100172186; -.
DR KEGG; pon:100172186; -.
DR CTD; 14; -.
DR eggNOG; KOG0296; Eukaryota.
DR GeneTree; ENSGT00940000153648; -.
DR HOGENOM; CLU_000288_57_9_1; -.
DR InParanoid; Q5RCG7; -.
DR OMA; WMWKVPS; -.
DR TreeFam; TF314543; -.
DR Proteomes; UP000001595; Chromosome 2B.
DR GO; GO:0009986; C:cell surface; ISS:UniProtKB.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0045171; C:intercellular bridge; IEA:Ensembl.
DR GO; GO:0015630; C:microtubule cytoskeleton; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008201; F:heparin binding; IEA:Ensembl.
DR GO; GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0010595; P:positive regulation of endothelial cell migration; ISS:UniProtKB.
DR GO; GO:0014909; P:smooth muscle cell migration; ISS:UniProtKB.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF00400; WD40; 5.
DR SMART; SM00320; WD40; 8.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 6.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 2: Evidence at transcript level;
KW Angiogenesis; Cell membrane; Cytoplasm; Developmental protein;
KW Differentiation; Membrane; Phosphoprotein; Reference proteome; Repeat;
KW WD repeat.
FT CHAIN 1..434
FT /note="Angio-associated migratory cell protein"
FT /id="PRO_0000050833"
FT REPEAT 89..129
FT /note="WD 1"
FT REPEAT 132..171
FT /note="WD 2"
FT REPEAT 173..212
FT /note="WD 3"
FT REPEAT 214..254
FT /note="WD 4"
FT REPEAT 258..299
FT /note="WD 5"
FT REPEAT 315..354
FT /note="WD 6"
FT REPEAT 356..395
FT /note="WD 7"
FT REPEAT 398..433
FT /note="WD 8"
FT REGION 1..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 30..63
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 20
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q13685"
FT CONFLICT 86
FT /note="T -> I (in Ref. 1; CAH90540)"
FT /evidence="ECO:0000305"
FT CONFLICT 125
FT /note="E -> G (in Ref. 1; CAH90540)"
FT /evidence="ECO:0000305"
FT CONFLICT 193..194
FT /note="TA -> H (in Ref. 1; CAH90540)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 434 AA; 46781 MW; 16B3815553EBA3B2 CRC64;
MESESESGAA ADTPPLETLS FHGDEEIIEV VELDPGPPDP DDLAQEMEDV DFEEEEEEEG
NEEGWVLEPQ EGVVGSMEGP DDSEVTFALH SASVFCVSLD PKTNTLAVTG GEDDKAFVWR
LSDGELLFEC AGHKDSVTCA GFSHDSTLVA TGDMSGLLKV WQVDTKEEVW SFEAGDLEWM
EWHPRAPVLL AGTADGNTWM WKVPNGDCKT FQGPNCPATC GRVLPDGKRA VVGYEDGTIR
IWDLKQGSPI HVLKGTEGHQ GPLTCVATNQ DGSLILTGSV DCQAKLVSAT TGKVVGVFRP
ETVASQPSLG EGEESESNSV ESLGFCSVMP LAAVGYLDGT LAIYDLATQT LRHQCQHQSG
IVQLLWEAGT AVVYTCSLDG IVRLWDARTG RLLTDYRGHT AEILDFALSK DASLVVTTSG
DHKAKVFCVQ RPDR