ID   RIR1_HHV6U              Reviewed;         804 AA.
AC   P52343; Q89941;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=Ribonucleoside-diphosphate reductase large subunit-like protein {ECO:0000255|HAMAP-Rule:MF_04027};
GN   Name=RIR1 {ECO:0000255|HAMAP-Rule:MF_04027}; Synonyms=P2LF2, U28;
OS   Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B
OS   lymphotropic virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Roseolovirus.
OX   NCBI_TaxID=10370;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8289364; DOI=10.1128/jvi.68.2.597-610.1994;
RA   Nicholas J., Martin M.E.D.;
RT   "Nucleotide sequence analysis of a 38.5-kilobase-pair region of the genome
RT   of human herpesvirus 6 encoding human cytomegalovirus immediate-early gene
RT   homologs and transactivating functions.";
RL   J. Virol. 68:597-610(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=7747482; DOI=10.1006/viro.1995.1228;
RA   Gompels U.A., Nicholas J., Lawrence G.L., Jones M., Thomson B.J.,
RA   Martin M.E.D., Efstathiou S., Craxton M.A., Macaulay H.A.;
RT   "The DNA sequence of human herpesvirus-6: structure, coding content, and
RT   genome evolution.";
RL   Virology 209:29-51(1995).
RN   [3]
RP   ABSENCE OF RIBONUCLEOTIDE REDUCTASE ACTIVITY, AND ABSENCE OF GENE FOR SMALL
RP   SUBUNIT.
RX   PubMed=10573165; DOI=10.1099/0022-1317-80-10-2713;
RA   Sun Y., Conner J.;
RT   "The U28 ORF of human herpesvirus-7 does not encode a functional
RT   ribonucleotide reductase R1 subunit.";
RL   J. Gen. Virol. 80:2713-2718(1999).
RN   [4]
RP   REVIEW.
RX   PubMed=18990579; DOI=10.1016/j.tibs.2008.09.008;
RA   Lembo D., Brune W.;
RT   "Tinkering with a viral ribonucleotide reductase.";
RL   Trends Biochem. Sci. 34:25-32(2009).
CC   -!- FUNCTION: Does not possess a ribonucleotide reductase activity.
CC       Betaherpesviruses probably use another strategy to expand the dNTP pool
CC       in a quiescent host cell. {ECO:0000255|HAMAP-Rule:MF_04027}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000255|HAMAP-Rule:MF_04027}. Host
CC       cytoplasm {ECO:0000255|HAMAP-Rule:MF_04027}.
CC   -!- SIMILARITY: Belongs to the ribonucleoside diphosphate reductase large
CC       chain family. {ECO:0000255|HAMAP-Rule:MF_04027}.
CC   -!- CAUTION: Lacks the conserved sequence Asn-x-Cys-x-Glu essential for
CC       ribonucleotide reductase activity. {ECO:0000255|HAMAP-Rule:MF_04027}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA16736.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; L25528; AAA16736.1; ALT_INIT; Genomic_DNA.
DR   EMBL; X83413; CAA58408.1; -; Genomic_DNA.
DR   PIR; T09323; T09323.
DR   RefSeq; NP_042921.1; NC_001664.2.
DR   SMR; P52343; -.
DR   PRIDE; P52343; -.
DR   DNASU; 1487905; -.
DR   GeneID; 1487905; -.
DR   KEGG; vg:1487905; -.
DR   Proteomes; UP000009295; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0044423; C:virion component; IEA:UniProtKB-UniRule.
DR   GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR   HAMAP; MF_04027; HSV_RIR1_betahv; 1.
DR   InterPro; IPR034716; HSV_RIR1_betahv.
DR   InterPro; IPR000788; RNR_lg_C.
DR   InterPro; IPR039718; Rrm1.
DR   PANTHER; PTHR11573; PTHR11573; 1.
DR   Pfam; PF02867; Ribonuc_red_lgC; 1.
DR   PRINTS; PR01183; RIBORDTASEM1.
DR   PROSITE; PS00089; RIBORED_LARGE; 1.
PE   1: Evidence at protein level;
KW   Host cytoplasm; Late protein; Reference proteome; Virion.
FT   CHAIN           1..804
FT                   /note="Ribonucleoside-diphosphate reductase large subunit-
FT                   like protein"
FT                   /id="PRO_0000187238"
SQ   SEQUENCE   804 AA;  93353 MW;  E01A17F36B571EAE CRC64;
     MKRKERRINK DYGYNRKCVC HYEASQKRFC YSQYSCASVL YERVRDIAKI IDRLDSGLDA
     WCLRDAIISV LRATHCVPRV DRMLGRWYLK TSVFYDFCPD DLILSCPNVI MPNVLNFVKK
     YRDFIRSVLY KVSVSWKNQY MPGVLAASRF LEEISNSLNG VEESIPCIYL RMCATLTEIV
     LRIGYLREIY QENPYVMFEE LAFSLFTQKW VLPFSCMTNL GLVEKANSTV FDVAIYNTCL
     YSLVDFTIVN GEHLFPALLN GSNISMNLTR YQQEAKNIFE ILLSQIRVVE RDTDKTVQLT
     VYVEVWHVSA LMWLDLYEAL PQTSRVTFCL IIPGIFMDRY ELKRAQWSLF HKNIAFELGK
     CDEITFSTKY LEFERTTDHA KITMSSFIEK ICLCLKGGRM GLIFRKNVYQ YSMIPHVPLY
     CGGDFLDVLP VRDGINTCMR MLLNVVHFLG DEVSDELTEE IDFVRLQCKF FMFNELRRVV
     RKMVLVANAV IDYAVENKDF LCEGIEDGRS LGICVTGLHS VFMTVGLSYA HPDARRLYRM
     ICEHIYYTCV RTSVDCCMKG AEPCNLFDRS KYALGMLYFD HFDNVECTLP EELWTTLRKD
     VLMHGVRNIH FTAGTAMQKE FDIINSSESF WPMEDNKILR RSNIKVVIGK DGLNDVTSVY
     SSELKSLYIP VYNNLLLNRF NKHQQYLKTV GYRVLNVDTN LFTDKELDDL AVFKDGFSYH
     LNDLIEMYKS GLPFLDQGQA NVFYFNDTVS LRLLLPLLYK AGFKVAMYKV LCNSEMYKHL
     DLSNPLPLIG KCSDGVVMHV KNIL