ID   RISC_AERPE              Reviewed;         155 AA.
AC   Q9YDC5;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   25-MAY-2022, entry version 100.
DE   RecName: Full=Riboflavin synthase;
DE            EC=2.5.1.9;
GN   Name=ribC; OrderedLocusNames=APE_0988;
OS   Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 /
OS   K1).
OC   Archaea; Crenarchaeota; Thermoprotei; Desulfurococcales;
OC   Desulfurococcaceae; Aeropyrum.
OX   NCBI_TaxID=272557;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1;
RX   PubMed=10382966; DOI=10.1093/dnares/6.2.83;
RA   Kawarabayasi Y., Hino Y., Horikawa H., Yamazaki S., Haikawa Y., Jin-no K.,
RA   Takahashi M., Sekine M., Baba S., Ankai A., Kosugi H., Hosoyama A.,
RA   Fukui S., Nagai Y., Nishijima K., Nakazawa H., Takamiya M., Masuda S.,
RA   Funahashi T., Tanaka T., Kudoh Y., Yamazaki J., Kushida N., Oguchi A.,
RA   Aoki K., Kubota K., Nakamura Y., Nomura N., Sako Y., Kikuchi H.;
RT   "Complete genome sequence of an aerobic hyper-thermophilic crenarchaeon,
RT   Aeropyrum pernix K1.";
RL   DNA Res. 6:83-101(1999).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) = 5-amino-6-(D-
CC         ribitylamino)uracil + riboflavin; Xref=Rhea:RHEA:20772,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:15934, ChEBI:CHEBI:57986,
CC         ChEBI:CHEBI:58201; EC=2.5.1.9;
CC   -!- PATHWAY: Cofactor biosynthesis; riboflavin biosynthesis; riboflavin
CC       from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-
CC       ribitylamino)uracil: step 2/2.
CC   -!- SIMILARITY: Belongs to the DMRL synthase family. {ECO:0000305}.
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DR   EMBL; BA000002; BAA79972.1; -; Genomic_DNA.
DR   PIR; D72696; D72696.
DR   AlphaFoldDB; Q9YDC5; -.
DR   SMR; Q9YDC5; -.
DR   STRING; 272557.APE_0988; -.
DR   PRIDE; Q9YDC5; -.
DR   EnsemblBacteria; BAA79972; BAA79972; APE_0988.
DR   KEGG; ape:APE_0988; -.
DR   PATRIC; fig|272557.25.peg.715; -.
DR   eggNOG; arCOG01322; Archaea.
DR   OMA; QLMTNTH; -.
DR   UniPathway; UPA00275; UER00405.
DR   Proteomes; UP000002518; Chromosome.
DR   GO; GO:0009349; C:riboflavin synthase complex; IEA:InterPro.
DR   GO; GO:0004746; F:riboflavin synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009231; P:riboflavin biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd09210; Riboflavin_synthase_archaeal; 1.
DR   Gene3D; 3.40.50.960; -; 1.
DR   InterPro; IPR002180; LS/RS.
DR   InterPro; IPR036467; LS/RS_sf.
DR   InterPro; IPR006399; Ribfl_synth_arc.
DR   Pfam; PF00885; DMRL_synthase; 1.
DR   PIRSF; PIRSF015750; Ribfl_synth_arc; 1.
DR   SUPFAM; SSF52121; SSF52121; 1.
DR   TIGRFAMs; TIGR01506; ribC_arch; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Riboflavin biosynthesis; Transferase.
FT   CHAIN           1..155
FT                   /note="Riboflavin synthase"
FT                   /id="PRO_0000134858"
SQ   SEQUENCE   155 AA;  16576 MW;  644B7A1BD313A4F3 CRC64;
     MGKCVGVADT TFARVDMGSV AEEVLRRRLP GYRIVRHTVP GIKDLPGAAK RILSMGCEGV
     ITLGWVGRRE ADKLSYLAAS VGLIMVEVLT GKIVIDVTVH EDEAEAPEEL AAIAVDRARK
     HAENLAALIR EGPEALVKHA GMGLRQGYPD AGPIK