ID   RITA1_BOVIN             Reviewed;         269 AA.
AC   Q2HJ75;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=RBPJ-interacting and tubulin-associated protein 1;
DE   AltName: Full=RBPJ-interacting and tubulin-associated protein;
GN   Name=RITA1; Synonyms=RITA;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Uterus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Tubulin-binding protein that acts as a negative regulator of
CC       Notch signaling pathway. Shuttles between the cytoplasm and the nucleus
CC       and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the
CC       interaction between RBPJ/RBPSUH and NICD product of Notch proteins
CC       (Notch intracellular domain), leading to down-regulate Notch-mediated
CC       transcription. May play a role in neurogenesis (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with RBPJ/RBPSUH. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC       Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
CC       {ECO:0000250}. Note=Shuttles rapidly between the cytoplasm and the
CC       nucleus. The function of centrosome localization is still unclear (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RITA family. {ECO:0000305}.
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DR   EMBL; BC113269; AAI13270.1; -; mRNA.
DR   RefSeq; NP_001039809.1; NM_001046344.1.
DR   AlphaFoldDB; Q2HJ75; -.
DR   STRING; 9913.ENSBTAP00000029525; -.
DR   PaxDb; Q2HJ75; -.
DR   PRIDE; Q2HJ75; -.
DR   GeneID; 533158; -.
DR   KEGG; bta:533158; -.
DR   CTD; 84934; -.
DR   eggNOG; ENOG502S61Y; Eukaryota.
DR   HOGENOM; CLU_062251_0_0_1; -.
DR   InParanoid; Q2HJ75; -.
DR   OrthoDB; 1387213at2759; -.
DR   TreeFam; TF337291; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005813; C:centrosome; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0015631; F:tubulin binding; ISS:UniProtKB.
DR   GO; GO:0045746; P:negative regulation of Notch signaling pathway; ISS:UniProtKB.
DR   GO; GO:0022008; P:neurogenesis; ISS:UniProtKB.
DR   GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
DR   GO; GO:0051168; P:nuclear export; ISS:UniProtKB.
DR   InterPro; IPR031418; RITA1.
DR   PANTHER; PTHR34917; PTHR34917; 1.
DR   Pfam; PF17066; RITA; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Cytoskeleton; Neurogenesis; Notch signaling pathway; Nucleus;
KW   Reference proteome.
FT   CHAIN           1..269
FT                   /note="RBPJ-interacting and tubulin-associated protein 1"
FT                   /id="PRO_0000294428"
FT   REGION          67..94
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          128..156
FT                   /note="Interaction with RBPJ/RBPSUH"
FT                   /evidence="ECO:0000250"
FT   REGION          145..269
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          156..269
FT                   /note="Interaction with tubulin"
FT                   /evidence="ECO:0000250"
FT   MOTIF           5..17
FT                   /note="Nuclear export signal"
FT                   /evidence="ECO:0000250"
FT   MOTIF           92..108
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000250"
FT   COMPBIAS        155..180
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        188..202
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        203..220
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        241..261
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   269 AA;  29087 MW;  70DD389B24E505F0 CRC64;
     MKTPVELAIS GMQTLHVQHR GRSGYRVKVR PSYVDETLFG SPAGTRPVPP DFDPPWMKKA
     NRSRGVGTGV SQALGANGSC ESTSSSGSTP TLTPRKKNKY RLISHTPSYC DESLFGSRQE
     GAGWEAKWMA RGDAAKLHAL FWTPPATPRG SHSPRPRETP VRCVHPADLS KTEHRVMASS
     RRLSVDGLDT PRPLRRERSH SLTHPNVPST GHTPASSPCT SGPRDPRPAP SGVTFRSPLV
     TPRAGSVSVS VPTTPRQGGA TQKTKPPWK