RITA1_MOUSE
ID RITA1_MOUSE Reviewed; 253 AA.
AC Q9D1H0;
DT 10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=RBPJ-interacting and tubulin-associated protein 1;
DE AltName: Full=RBPJ-interacting and tubulin-associated protein;
GN Name=Rita1; Synonyms=Rita;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Embryo;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Tubulin-binding protein that acts as a negative regulator of
CC Notch signaling pathway. Shuttles between the cytoplasm and the nucleus
CC and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the
CC interaction between RBPJ/RBPSUH and NICD product of Notch proteins
CC (Notch intracellular domain), leading to down-regulate Notch-mediated
CC transcription. May play a role in neurogenesis (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Interacts with RBPJ/RBPSUH. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
CC {ECO:0000250}. Note=Shuttles rapidly between the cytoplasm and the
CC nucleus. The function of centrosome localization is still unclear (By
CC similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the RITA family. {ECO:0000305}.
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DR EMBL; AK003581; BAB22871.1; -; mRNA.
DR EMBL; BC021365; AAH21365.1; -; mRNA.
DR CCDS; CCDS51635.1; -.
DR RefSeq; NP_083372.1; NM_029096.3.
DR RefSeq; NP_598669.1; NM_133908.1.
DR AlphaFoldDB; Q9D1H0; -.
DR STRING; 10090.ENSMUSP00000031599; -.
DR iPTMnet; Q9D1H0; -.
DR PhosphoSitePlus; Q9D1H0; -.
DR PaxDb; Q9D1H0; -.
DR PRIDE; Q9D1H0; -.
DR ProteomicsDB; 253325; -.
DR Antibodypedia; 51448; 90 antibodies from 14 providers.
DR Ensembl; ENSMUST00000031599; ENSMUSP00000031599; ENSMUSG00000029600.
DR Ensembl; ENSMUST00000177800; ENSMUSP00000136946; ENSMUSG00000029600.
DR GeneID; 100764; -.
DR KEGG; mmu:100764; -.
DR UCSC; uc008zhp.2; mouse.
DR CTD; 84934; -.
DR MGI; MGI:1922021; Rita1.
DR VEuPathDB; HostDB:ENSMUSG00000029600; -.
DR eggNOG; ENOG502S61Y; Eukaryota.
DR GeneTree; ENSGT00390000013005; -.
DR HOGENOM; CLU_062251_0_0_1; -.
DR InParanoid; Q9D1H0; -.
DR OMA; EGPWMAK; -.
DR OrthoDB; 1387213at2759; -.
DR PhylomeDB; Q9D1H0; -.
DR TreeFam; TF337291; -.
DR BioGRID-ORCS; 100764; 3 hits in 71 CRISPR screens.
DR PRO; PR:Q9D1H0; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; Q9D1H0; protein.
DR Bgee; ENSMUSG00000029600; Expressed in embryonic brain and 205 other tissues.
DR ExpressionAtlas; Q9D1H0; baseline and differential.
DR Genevisible; Q9D1H0; MM.
DR GO; GO:0005813; C:centrosome; ISS:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0015631; F:tubulin binding; ISS:UniProtKB.
DR GO; GO:0045746; P:negative regulation of Notch signaling pathway; ISS:UniProtKB.
DR GO; GO:0022008; P:neurogenesis; ISS:UniProtKB.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0051168; P:nuclear export; ISS:UniProtKB.
DR InterPro; IPR031418; RITA1.
DR PANTHER; PTHR34917; PTHR34917; 1.
DR Pfam; PF17066; RITA; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Cytoskeleton; Neurogenesis; Notch signaling pathway; Nucleus;
KW Reference proteome.
FT CHAIN 1..253
FT /note="RBPJ-interacting and tubulin-associated protein 1"
FT /id="PRO_0000294430"
FT REGION 30..89
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 112..140
FT /note="Interaction with RBPJ/RBPSUH"
FT /evidence="ECO:0000250"
FT REGION 127..175
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 140..253
FT /note="Interaction with tubulin"
FT /evidence="ECO:0000250"
FT REGION 188..253
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 81..97
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000250"
FT COMPBIAS 70..84
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 158..175
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 188..228
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 239..253
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 253 AA; 27071 MW; 239EC9BD9CF4FA61 CRC64;
MKALHLQHRS PTSYRVKARA SYVDETLFGS PARTRPAQPD FDPPWVQNCN RSRGVGPGPP
KGSLAKRDCE SPSSRGSTPN LTPRKKNKYR LIGHAPSYCD ESLFGTSKEG SRMAVGDAAK
LRTLFWTPPA TPRGSHTPCP RETPLRAIHP AGPSRTEPRV TAGSQMSSQD GLCVPCSLGQ
RRSHSLTHLT VPSTGHPASS APQTNGPWSP RPNTSGATVQ SPLVTSKACS GRVSGPAPPR
RGACPPKPKP PWK
