ID   RITA1_RAT               Reviewed;         258 AA.
AC   Q2KJ10;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=RBPJ-interacting and tubulin-associated protein 1;
DE   AltName: Full=RBPJ-interacting and tubulin-associated protein;
GN   Name=Rita1; Synonyms=Rita;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Prostate;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Tubulin-binding protein that acts as a negative regulator of
CC       Notch signaling pathway. Shuttles between the cytoplasm and the nucleus
CC       and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the
CC       interaction between RBPJ/RBPSUH and NICD product of Notch proteins
CC       (Notch intracellular domain), leading to down-regulate Notch-mediated
CC       transcription. May play a role in neurogenesis (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with RBPJ/RBPSUH. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC       Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
CC       {ECO:0000250}. Note=Shuttles rapidly between the cytoplasm and the
CC       nucleus. The function of centrosome localization is still unclear (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RITA family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC112384; AAI12385.1; -; mRNA.
DR   RefSeq; NP_001037691.1; NM_001044226.1.
DR   RefSeq; XP_006249445.1; XM_006249383.3.
DR   RefSeq; XP_006249446.1; XM_006249384.3.
DR   AlphaFoldDB; Q2KJ10; -.
DR   STRING; 10116.ENSRNOP00000054067; -.
DR   PaxDb; Q2KJ10; -.
DR   PRIDE; Q2KJ10; -.
DR   Ensembl; ENSRNOT00000057242; ENSRNOP00000054067; ENSRNOG00000037720.
DR   GeneID; 288683; -.
DR   KEGG; rno:288683; -.
DR   CTD; 84934; -.
DR   RGD; 1306772; Rita1.
DR   eggNOG; ENOG502S61Y; Eukaryota.
DR   GeneTree; ENSGT00390000013005; -.
DR   HOGENOM; CLU_062251_0_0_1; -.
DR   InParanoid; Q2KJ10; -.
DR   OMA; EGPWMAK; -.
DR   OrthoDB; 1387213at2759; -.
DR   PhylomeDB; Q2KJ10; -.
DR   TreeFam; TF337291; -.
DR   PRO; PR:Q2KJ10; -.
DR   Proteomes; UP000002494; Chromosome 12.
DR   Bgee; ENSRNOG00000037720; Expressed in skeletal muscle tissue and 20 other tissues.
DR   Genevisible; Q2KJ10; RN.
DR   GO; GO:0005813; C:centrosome; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0015631; F:tubulin binding; ISS:UniProtKB.
DR   GO; GO:0045746; P:negative regulation of Notch signaling pathway; ISS:UniProtKB.
DR   GO; GO:0022008; P:neurogenesis; ISS:UniProtKB.
DR   GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
DR   GO; GO:0051168; P:nuclear export; ISS:UniProtKB.
DR   InterPro; IPR031418; RITA1.
DR   PANTHER; PTHR34917; PTHR34917; 1.
DR   Pfam; PF17066; RITA; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Cytoskeleton; Neurogenesis; Notch signaling pathway; Nucleus;
KW   Reference proteome.
FT   CHAIN           1..258
FT                   /note="RBPJ-interacting and tubulin-associated protein 1"
FT                   /id="PRO_0000294431"
FT   REGION          28..86
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          117..145
FT                   /note="Interaction with RBPJ/RBPSUH"
FT                   /evidence="ECO:0000250"
FT   REGION          132..182
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          145..258
FT                   /note="Interaction with tubulin"
FT                   /evidence="ECO:0000250"
FT   REGION          195..258
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           81..97
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000250"
FT   COMPBIAS        70..84
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        195..246
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   258 AA;  28148 MW;  CB48B0F96C0609F0 CRC64;
     MQALHLQHRN PRSYRVKARA SYVDETLFGS PTGTRPTLPD FDPPWVQNCN RSRGVSPGPP
     KVSLAKRDCE SPSSRGSTPN LTPRKKNKYR LIGHTPSYCD ESLFGSRPQG TSKERSRTAV
     EDAAKLRTLF WTPPATPRGS HSPRPRETPL RAIHPTGPPR TEPRVATGSQ MVSRDGLDAP
     RSLGQRRSYS LTHLAVPSTG HPASTAPQTN GPWSPRPYTS GATVQSPLVT RKVCSGSVSG
     PTTPQRGACP QKPKPPWK