ID   RIX1_CANAL              Reviewed;         769 AA.
AC   Q59RA0; A0A1D8PM99;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2017, sequence version 2.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Pre-rRNA-processing protein RIX1;
GN   Name=RIX1; OrderedLocusNames=CAALFM_C405230CA;
GN   ORFNames=CaO19.14152, CaO19.6862;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC   -!- FUNCTION: Component of the RIX1 complex required for processing of ITS2
CC       sequences from 35S pre-rRNA and the nucleoplasmic transit of the pre-
CC       60S ribosomal subunits. Regulates pre-60S association of the critical
CC       remodeling factor MDN1. {ECO:0000250|UniProtKB:P38883}.
CC   -!- SUBUNIT: Component of the RIX1 complex, composed of IPI1, RIX1/IPI2 and
CC       IPI3 in a 1:2:2 stoichiometry. The complex interacts (via RIX1) with
CC       MDN1 (via its hexameric AAA ATPase ring) and the pre-60S ribosome
CC       particles. {ECO:0000250|UniProtKB:P38883}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P38883}.
CC   -!- SIMILARITY: Belongs to the RIX1/PELP1 family. {ECO:0000305}.
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DR   EMBL; CP017626; AOW29262.1; -; Genomic_DNA.
DR   RefSeq; XP_712250.2; XM_707157.2.
DR   AlphaFoldDB; Q59RA0; -.
DR   SMR; Q59RA0; -.
DR   STRING; 237561.Q59RA0; -.
DR   PRIDE; Q59RA0; -.
DR   GeneID; 3646156; -.
DR   KEGG; cal:CAALFM_C405230CA; -.
DR   CGD; CAL0000185245; orf19.14152.
DR   VEuPathDB; FungiDB:C4_05230C_A; -.
DR   eggNOG; ENOG502R65X; Eukaryota.
DR   HOGENOM; CLU_020084_1_0_1; -.
DR   InParanoid; Q59RA0; -.
DR   OrthoDB; 427039at2759; -.
DR   PRO; PR:Q59RA0; -.
DR   Proteomes; UP000000559; Chromosome 4.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0006364; P:rRNA processing; IBA:GO_Central.
DR   InterPro; IPR012583; RIX1_N.
DR   Pfam; PF08167; RIX1; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Ribosome biogenesis; rRNA processing.
FT   CHAIN           1..769
FT                   /note="Pre-rRNA-processing protein RIX1"
FT                   /id="PRO_0000308915"
FT   REGION          456..488
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          715..769
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        456..477
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        717..741
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        742..769
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   769 AA;  87628 MW;  A11066440E3E2C64 CRC64;
     MSINIVLEEI KGTPSSIIPL LSILHNDKQI LSTITKTELN HLISRTLNLV RSSDVYNKWC
     GINLIRVIVE EYSILASEGN NLMNSLLQVL EAYQQQQHHH HHQTTIDLKI LTSCIETINY
     MGDLIRGKPT LTREILTPKL NSIIGYYFQY LHFAPLLILN SLQTLLKFHP TTFRPFGNKL
     KTKLINLIDG GGGEEFINYP QDLQLSIYNT LAMLPIIEKI EPETKWYNDV INILGEINGL
     IQIYQEFLNF KDDQDLSNLI QKLPNRPTTT TTTTKLLTDL SIDFNKPQTI LSISNHLNIL
     MGVLKSYLTV ETLFTVKLPL GLILTTCELI CSINTKFLSF KGDIRDETIK KLIKFSLIEN
     YKTTLGVLIE LIELYKGSLI PHLTTIWSFL ETLIPFQNQN KRIVNEEIIE SESLYVEILQ
     FMKQSLSLLG NVSENTQLLR FVDMALILVE PRINPTTTTT TTNNNNNNNN TKQTNVQQGK
     KQKKRKNTSS VALSDILSHE HLFMTNIPTI TITTVRSFIN QIITKIILPP TQHYKIMRYL
     IIESIHAKYY NLYHNVPIEL KKLLINAVLY PGYDKISILP IISTILSDDP LLGVFNNPKF
     PPLPKYINLV NNIEEEEQKE EQEEDAIIED EVEEPIKEEL TTPLKKRKLD IESNEETDNN
     NIIPVEDQSK IFTATKVEKL TTTTTSSIEN NPVVIEELTS SKEIVVESPV DEPTKVDNII
     PTTTTTTTTT TSLTSNTANA NDDNDNDDDD ESSDFEMPEI NLDQDSDDE