ID   RIX1_KLULA              Reviewed;         776 AA.
AC   Q6CWH3;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Pre-rRNA-processing protein RIX1;
GN   Name=RIX1; OrderedLocusNames=KLLA0B04092g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Component of the RIX1 complex required for processing of ITS2
CC       sequences from 35S pre-rRNA and the nucleoplasmic transit of the pre-
CC       60S ribosomal subunits. Regulates pre-60S association of the critical
CC       remodeling factor MDN1. {ECO:0000250|UniProtKB:P38883}.
CC   -!- SUBUNIT: Component of the RIX1 complex, composed of IPI1, RIX1/IPI2 and
CC       IPI3 in a 1:2:2 stoichiometry. The complex interacts (via RIX1) with
CC       MDN1 (via its hexameric AAA ATPase ring) and the pre-60S ribosome
CC       particles. {ECO:0000250|UniProtKB:P38883}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P38883}.
CC   -!- SIMILARITY: Belongs to the RIX1/PELP1 family. {ECO:0000305}.
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DR   EMBL; CR382122; CAH02109.1; -; Genomic_DNA.
DR   RefSeq; XP_451716.1; XM_451716.1.
DR   AlphaFoldDB; Q6CWH3; -.
DR   SMR; Q6CWH3; -.
DR   STRING; 28985.XP_451716.1; -.
DR   EnsemblFungi; CAH02109; CAH02109; KLLA0_B04092g.
DR   GeneID; 2897546; -.
DR   KEGG; kla:KLLA0_B04092g; -.
DR   eggNOG; ENOG502R65X; Eukaryota.
DR   HOGENOM; CLU_020084_0_0_1; -.
DR   InParanoid; Q6CWH3; -.
DR   OMA; WCGINLI; -.
DR   Proteomes; UP000000598; Chromosome B.
DR   GO; GO:0005829; C:cytosol; IEA:EnsemblFungi.
DR   GO; GO:0005654; C:nucleoplasm; IEA:EnsemblFungi.
DR   GO; GO:0097344; C:Rix1 complex; IEA:EnsemblFungi.
DR   GO; GO:0003682; F:chromatin binding; IEA:EnsemblFungi.
DR   GO; GO:0006267; P:pre-replicative complex assembly involved in nuclear cell cycle DNA replication; IEA:EnsemblFungi.
DR   GO; GO:0030174; P:regulation of DNA-templated DNA replication initiation; IEA:EnsemblFungi.
DR   GO; GO:0000027; P:ribosomal large subunit assembly; IEA:EnsemblFungi.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   InterPro; IPR012583; RIX1_N.
DR   Pfam; PF08167; RIX1; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Ribosome biogenesis; rRNA processing.
FT   CHAIN           1..776
FT                   /note="Pre-rRNA-processing protein RIX1"
FT                   /id="PRO_0000308918"
FT   REGION          699..776
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        699..722
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        723..764
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   776 AA;  87936 MW;  97FFDF10D791E968 CRC64;
     MATVTVPLSS LAKLIEESEG SQFRSILQTL RSPTYVNQSL LKSDIGVFVA KLLKLLRSSE
     PYQIWKGCHA VAVLCSNNPV VLCSQANQFL TVLYTRLESF INFYVETSQS AARLTTLKTL
     TRTVDILMDL IRGKPTLTRE ALTPKLNAVI PLLMTLCQYE PELCLPILKK LLLQNTTTFK
     PFANKYRVIL NRLITKDFQL YDRTTQRLIC DNFAYLHLIK QNAQKLEENQ EHHKTLMDEN
     WRSSILSVLY QFKPLILLCG DILDFSVDSE MLNFIDSLPT PKKDTGEIKD ELFAPLSVDM
     NESFSLWEIS YRVEVLSQLL ISFISLPTSF PLRIPLHGII DICQALLMLS TNYLPLKRGL
     RRETELTAVI ITVLRSLQYQ GIVVLKSISR CYGKDILYYY SSILSSLELF IPIKARGNAI
     DYEKVESMKE QVFDLLSLIN TLAGHLGHKI DELDLFTKLT DITLRLVEEK SNLGKFYTTV
     NDAKSIKQTT KQKKDYNKMA GAMSDIYSHP KQFVNKTELR WYDEANKFLS LVVQNWKLPS
     TQQVNIIKYA TVMSITLNEQ IGNIPESFEE LLTTIVLYPG SERLSILPIA VGLLKNMDNK
     VFDVLCNPRL PFSCLLNPGS SSIRKDIRNA LKMPNGDSDE TEETIVTGQQ DVLDQSDANG
     IVTANDIERD RDGPENSIEK PLSALTSIVS DESQIFRKRA VEESESEEEE TKRQRPDSAE
     ETENNGETVV IPNVPTQVLQ TVETTETAQQ PDSDSDSEIE IPTINVSDND DDDDEE