ID   RIX1_PICST              Reviewed;         724 AA.
AC   A3GF61;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JAN-2010, sequence version 2.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=Pre-rRNA-processing protein RIX1;
GN   Name=RIX1; ORFNames=PICST_52773;
OS   Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL
OS   Y-11545) (Yeast) (Pichia stipitis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Scheffersomyces.
OX   NCBI_TaxID=322104;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545;
RX   PubMed=17334359; DOI=10.1038/nbt1290;
RA   Jeffries T.W., Grigoriev I.V., Grimwood J., Laplaza J.M., Aerts A.,
RA   Salamov A., Schmutz J., Lindquist E., Dehal P., Shapiro H., Jin Y.-S.,
RA   Passoth V., Richardson P.M.;
RT   "Genome sequence of the lignocellulose-bioconverting and xylose-fermenting
RT   yeast Pichia stipitis.";
RL   Nat. Biotechnol. 25:319-326(2007).
CC   -!- FUNCTION: Component of the RIX1 complex required for processing of ITS2
CC       sequences from 35S pre-rRNA and the nucleoplasmic transit of the pre-
CC       60S ribosomal subunits. Regulates pre-60S association of the critical
CC       remodeling factor MDN1. {ECO:0000250|UniProtKB:P38883}.
CC   -!- SUBUNIT: Component of the RIX1 complex, composed of IPI1, RIX1/IPI2 and
CC       IPI3 in a 1:2:2 stoichiometry. The complex interacts (via RIX1) with
CC       MDN1 (via its hexameric AAA ATPase ring) and the pre-60S ribosome
CC       particles. {ECO:0000250|UniProtKB:P38883}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P38883}.
CC   -!- SIMILARITY: Belongs to the RIX1/PELP1 family. {ECO:0000305}.
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DR   EMBL; AAVQ01000001; EAZ63293.2; -; Genomic_DNA.
DR   RefSeq; XP_001387316.2; XM_001387279.1.
DR   AlphaFoldDB; A3GF61; -.
DR   SMR; A3GF61; -.
DR   STRING; 4924.XP_001387316.2; -.
DR   EnsemblFungi; EAZ63293; EAZ63293; PICST_52773.
DR   GeneID; 4850910; -.
DR   KEGG; pic:PICST_52773; -.
DR   eggNOG; ENOG502R65X; Eukaryota.
DR   HOGENOM; CLU_020084_1_0_1; -.
DR   InParanoid; A3GF61; -.
DR   OMA; WCGINLI; -.
DR   OrthoDB; 427039at2759; -.
DR   Proteomes; UP000002258; Chromosome 1.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR012583; RIX1_N.
DR   Pfam; PF08167; RIX1; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Ribosome biogenesis; rRNA processing.
FT   CHAIN           1..724
FT                   /note="Pre-rRNA-processing protein RIX1"
FT                   /id="PRO_0000308921"
FT   REGION          444..464
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          592..644
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          656..724
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        593..609
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        610..639
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        705..724
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   724 AA;  82686 MW;  8E964CCD369D82D3 CRC64;
     MSIPLSLVLK QLEGSPSSVV PLLSTLYYDK SILNNISKSD SKHLVSRILN LTRSPIEYNK
     WAGTNLIRVI SDNYTILATE GSNLFGELVK NLDSYNDTVN IKVLTSTVEA LNYLCDKIRG
     KPTMTREILT PKLSTIITLY MDKLHFSPLI IIKSLKKLIQ FHPTTFRPFG NKLRAKLITF
     LHLQDFVNFP EPLKSAIYQT LASLPAIEKT EPELKWESDV KSLIKELKSV LAIYNEFLNL
     GDDSSLPRLF EQLPSFEENQ KNDKILPDMV IDVNEPSSVF QISTRVDILL NLLNAYVTYA
     TQFSVKVPLG LVLVVNEIIC SINVRYISYK NDVRDEQIRK IVKSTTVLNS LNSIKFLKDL
     AFTYKGSMLP HLGNILSLLE VLVPFKNKKI DYDELIIQEV LNRELLSCVS VYLSLVSFLS
     DHTQLLRFVD VGLLLVEPRI TDSTAQQNNN NHNSNGGKKH KKNKNTTAIP LSDILSHQHL
     FNEAIPEATV NIVRQFMSAV ITTVTLPPTQ HYKIMRYILI QAVHSRYYNN EHLIPRELRS
     LLINAVLYPG YEKISLLPIV STILGDDPLL SVFNNPRFPP LPIYVKNVKD ESVFEEEEEE
     EEEHEQEEKE IELPEQKRAI DEDELPEAKK RKMEDEPQVI QQEQIEQVVE DKIFTKVNPE
     TVVHFAPTKE VEPESRTIQN QKPETVPEPV PVAPVQQMSQ NINGDEDESD FEMPEIDVDD
     SDEE