ID   RK1_RABIT               Reviewed;          32 AA.
AC   P81655;
DT   20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   20-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Corticostatin-related peptide RK-1;
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [1]
RP   PROTEIN SEQUENCE, AND MASS SPECTROMETRY.
RC   TISSUE=Kidney;
RX   PubMed=8631871; DOI=10.1074/jbc.271.18.10654;
RA   Bateman A., MacLeod R.J., Lembessis P., Hu J., Esch F., Solomon S.;
RT   "The isolation and characterization of a novel corticostatin/defensin-like
RT   peptide from the kidney.";
RL   J. Biol. Chem. 271:10654-10659(1996).
RN   [2]
RP   STRUCTURE BY NMR.
RX   PubMed=11123900; DOI=10.1021/bi000457l;
RA   McManus A.M., Dawson N.F., Wade J.D., Carrington L.E., Winzor D.J.,
RA   Craik D.J.;
RT   "Three-dimensional structure of RK-1: a novel alpha-defensin peptide.";
RL   Biochemistry 39:15757-15764(2000).
CC   -!- FUNCTION: Has antimicrobial activity against E.coli and activates ion
CC       channel activity.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- MASS SPECTROMETRY: Mass=3701; Method=Electrospray;
CC       Evidence={ECO:0000269|PubMed:8631871};
CC   -!- SIMILARITY: Belongs to the alpha-defensin family. {ECO:0000305}.
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DR   PDB; 1EWS; NMR; -; A=1-32.
DR   PDBsum; 1EWS; -.
DR   AlphaFoldDB; P81655; -.
DR   SMR; P81655; -.
DR   STRING; 9986.ENSOCUP00000016855; -.
DR   HOGENOM; CLU_3394175_0_0_1; -.
DR   EvolutionaryTrace; P81655; -.
DR   Proteomes; UP000001811; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   InterPro; IPR041002; Defensin_RK-1.
DR   Pfam; PF17860; Defensin_RK-1; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Antibiotic; Antimicrobial; Defensin;
KW   Direct protein sequencing; Disulfide bond; Reference proteome; Secreted.
FT   PEPTIDE         1..32
FT                   /note="Corticostatin-related peptide RK-1"
FT                   /id="PRO_0000044720"
FT   DISULFID        3..29
FT   DISULFID        5..19
FT   DISULFID        9..28
FT   STRAND          3..8
FT                   /evidence="ECO:0007829|PDB:1EWS"
FT   STRAND          13..17
FT                   /evidence="ECO:0007829|PDB:1EWS"
FT   STRAND          20..23
FT                   /evidence="ECO:0007829|PDB:1EWS"
FT   STRAND          25..30
FT                   /evidence="ECO:0007829|PDB:1EWS"
SQ   SEQUENCE   32 AA;  3707 MW;  2D8015B628C8CA21 CRC64;
     MPCSCKKYCD PWEVIDGSCG LFNSKYICCR EK