ID   RL101_PLAVT             Reviewed;         466 AA.
AC   P0CV39;
DT   18-SEP-2019, integrated into UniProtKB/Swiss-Prot.
DT   18-SEP-2019, sequence version 1.
DT   25-MAY-2022, entry version 8.
DE   RecName: Full=Secreted RxLR effector protein 101 {ECO:0000303|PubMed:29706971};
DE   Flags: Precursor;
GN   Name=RXLR101 {ECO:0000303|PubMed:29706971};
OS   Plasmopara viticola (Downy mildew of grapevine) (Botrytis viticola).
OC   Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC   Plasmopara.
OX   NCBI_TaxID=143451;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], DOMAIN, FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=29706971; DOI=10.3389/fpls.2018.00286;
RA   Liu Y., Lan X., Song S., Yin L., Dry I.B., Qu J., Xiang J., Lu J.;
RT   "In planta functional analysis and subcellular localization of the oomycete
RT   pathogen Plasmopara viticola candidate RXLR effector repertoire.";
RL   Front. Plant Sci. 9:286-286(2018).
CC   -!- FUNCTION: Secreted effector that partially suppresses the host cell
CC       death induced by cell death-inducing proteins.
CC       {ECO:0000269|PubMed:29706971}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:29706971}. Host
CC       nucleus {ECO:0000269|PubMed:29706971}.
CC   -!- DOMAIN: The RxLR-dEER motif acts to carry the protein into the host
CC       cell cytoplasm through binding to cell surface phosphatidylinositol-3-
CC       phosphate. {ECO:0000305|PubMed:29706971}.
CC   -!- SIMILARITY: Belongs to the RxLR effector family. {ECO:0000305}.
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DR   AlphaFoldDB; P0CV39; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
PE   2: Evidence at transcript level;
KW   Host nucleus; Secreted; Signal; Virulence.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..466
FT                   /note="Secreted RxLR effector protein 101"
FT                   /id="PRO_0000447948"
FT   REGION          99..127
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          384..405
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           48..63
FT                   /note="RxLR-dEER"
FT                   /evidence="ECO:0000305|PubMed:29706971"
SQ   SEQUENCE   466 AA;  52118 MW;  8D6E746ABF4C5C39 CRC64;
     MRGAYSVITA LLVVASSQIA AESDYQLQVY HHDVTVAGNA VVKSLPKRYL RGSQHVHDSN
     EERSVYSVLA SMINEGVSKM PQAAEAVEKM PQAAEAVKKM PHAATAGKKV SRVTRTGKKM
     TSHGANARKG PLRADFVEKM PHAAEAKEEM QRANQHDLLK AIHQADEALE KSWHPSSDTA
     AIRYASHGIS SNVILTLKEW RKNFRGMREM AVSSEHKDII KPIHKAFVRL CGENMDPTTI
     EMSHIWNMMD WNVAASPATS HRQNLVSQAQ RYVLIGLRSM KKDPAVWKEW NKLSKSLRFG
     VLDYLLNLHY QRWVRMYNIF KRHRPDKWDV PMNDKLSLDG NTDTNSALAL QTHSNKQSLY
     PNEPSNAAWT SKGDRFVSSK RSRRTFNGNT DTASLPSKRS KVRSSKSFVP LSTESTTFGD
     HSVSTKTSRV SAVAPPKRPK AHNLDVLASA ATALALKDSE FVMHES