ID   RL105_PLAVT             Reviewed;         522 AA.
AC   P0CV42;
DT   18-SEP-2019, integrated into UniProtKB/Swiss-Prot.
DT   18-SEP-2019, sequence version 1.
DT   25-MAY-2022, entry version 8.
DE   RecName: Full=Secreted RxLR effector protein 105 {ECO:0000303|PubMed:29706971};
DE   Flags: Precursor;
GN   Name=RXLR105 {ECO:0000303|PubMed:29706971};
OS   Plasmopara viticola (Downy mildew of grapevine) (Botrytis viticola).
OC   Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC   Plasmopara.
OX   NCBI_TaxID=143451;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], DOMAIN, FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=29706971; DOI=10.3389/fpls.2018.00286;
RA   Liu Y., Lan X., Song S., Yin L., Dry I.B., Qu J., Xiang J., Lu J.;
RT   "In planta functional analysis and subcellular localization of the oomycete
RT   pathogen Plasmopara viticola candidate RXLR effector repertoire.";
RL   Front. Plant Sci. 9:286-286(2018).
CC   -!- FUNCTION: Secreted effector that dos not suppress the host cell death
CC       induced by cell death-inducing proteins. {ECO:0000269|PubMed:29706971}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:29706971}. Host
CC       nucleus {ECO:0000269|PubMed:29706971}. Host cytoplasm
CC       {ECO:0000269|PubMed:29706971}.
CC   -!- DOMAIN: The RxLR-dEER motif acts to carry the protein into the host
CC       cell cytoplasm through binding to cell surface phosphatidylinositol-3-
CC       phosphate. {ECO:0000305|PubMed:29706971}.
CC   -!- SIMILARITY: Belongs to the RxLR effector family. {ECO:0000305}.
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DR   AlphaFoldDB; P0CV42; -.
DR   SMR; P0CV42; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
PE   2: Evidence at transcript level;
KW   Host cytoplasm; Host nucleus; Secreted; Signal; Virulence.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..522
FT                   /note="Secreted RxLR effector protein 105"
FT                   /id="PRO_0000447951"
FT   MOTIF           48..63
FT                   /note="RxLR-dEER"
FT                   /evidence="ECO:0000305|PubMed:29706971"
SQ   SEQUENCE   522 AA;  58121 MW;  B45CF22CB6C900FE CRC64;
     MRGPCSVITA LLVVASSQIA AESDYRLQAY HHDVTAVGNA VVKPLPKRYL RGSQHVLDSN
     EERSVYSVLA SMINEGVSKM PQAAEAVEKM PQAAEAVEKM PQAAEAVEKM PQAAEAVEKM
     PQAAEAVEKM PSAAMAGKKV SRVTKTGKKM PHAAEIEAVE ETLHATNARK EPLRADFVEE
     MPHAAKAKEE MRRAKQHDLL RATEEADEAL EKSWHSSEDT AAIGGASRGI SSNVILSLKK
     WKNNFQGMRA MAVSGEHEDI IKPIHEAFVR LCGENMEPTT KEMTLIRNML DWDVAASPES
     SHRQNLVSQA QRHVLIGLRI MQRDPEVWNE WNELSESLRF GVLDYLLNLH YQRWVRMYNI
     FKRHRPDKKD VPMNDKLSLG GNTDKNSALA LQTHSKKQNL YPDEPSNVAW TSKKRDGSVL
     IERSKRTFNG NTDTASVPYK QLKMQSLKPV MPFLTRSTTS GHHSVSIKNP GLSFDGPIFA
     FVPPNVHKSQ SLTPPLVHKD VDTELSLGGI YDRSTHKAPT VP