RL10L_MOUSE
ID RL10L_MOUSE Reviewed; 214 AA.
AC P86048;
DT 25-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT 25-NOV-2008, sequence version 1.
DT 03-AUG-2022, entry version 90.
DE RecName: Full=60S ribosomal protein L10-like {ECO:0000303|PubMed:28502657};
GN Name=Rpl10l {ECO:0000303|PubMed:28502657, ECO:0000312|MGI:MGI:3647985};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis {ECO:0000269|PubMed:15489334};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP FUNCTION, TISSUE SPECIFICITY, AND DISRUPTION PHENOTYPE.
RX PubMed=28502657; DOI=10.1016/j.cub.2017.04.017;
RA Jiang L., Li T., Zhang X., Zhang B., Yu C., Li Y., Fan S., Jiang X.,
RA Khan T., Hao Q., Xu P., Nadano D., Huleihel M., Lunenfeld E., Wang P.J.,
RA Zhang Y., Shi Q.;
RT "RPL10L is required for male meiotic division by compensating for RPL10
RT during meiotic sex chromosome inactivation in mice.";
RL Curr. Biol. 27:1498-1505(2017).
CC -!- FUNCTION: Testis-specific component of the ribosome, which is required
CC for the transition from prophase to metaphase in male meiosis I
CC (PubMed:28502657). Compensates for the inactivated X-linked RPL10
CC paralog during spermatogenesis (PubMed:28502657). The ribosome is a
CC large ribonucleoprotein complex responsible for the synthesis of
CC proteins in the cell (PubMed:28502657). The small ribosomal subunit
CC (SSU) binds messenger RNAs (mRNAs) and translates the encoded message
CC by selecting cognate aminoacyl-transfer RNA (tRNA) molecules (By
CC similarity). The large subunit (LSU) contains the ribosomal catalytic
CC site termed the peptidyl transferase center (PTC), which catalyzes the
CC formation of peptide bonds, thereby polymerizing the amino acids
CC delivered by tRNAs into a polypeptide chain (By similarity). The
CC nascent polypeptides leave the ribosome through a tunnel in the LSU and
CC interact with protein factors that function in enzymatic processing,
CC targeting, and the membrane insertion of nascent chains at the exit of
CC the ribosomal tunnel (By similarity). {ECO:0000250|UniProtKB:Q96L21,
CC ECO:0000269|PubMed:28502657}.
CC -!- SUBUNIT: Component of the 60S large ribosomal subunit (LSU).
CC {ECO:0000305|PubMed:28502657}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q96L21}.
CC -!- TISSUE SPECIFICITY: Testis-specific. {ECO:0000269|PubMed:28502657}.
CC -!- DISRUPTION PHENOTYPE: Spermatogenic failure and male infertility
CC (PubMed:28502657). Spermatocytes show defects in the transition from
CC prophase to metaphase of meiosis I due to impaired ribosome biogenesis
CC in late prophase spermatocytes (PubMed:28502657).
CC {ECO:0000269|PubMed:28502657}.
CC -!- SIMILARITY: Belongs to the universal ribosomal protein uL16 family.
CC {ECO:0000305}.
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DR EMBL; AC125344; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC052145; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS49076.1; -.
DR RefSeq; NP_001156405.1; NM_001162933.1.
DR PDB; 7CPV; EM; 3.03 A; LI=1-214.
DR PDB; 7LS1; EM; 3.30 A; D1=1-214.
DR PDB; 7LS2; EM; 3.10 A; D1=1-214.
DR PDBsum; 7CPV; -.
DR PDBsum; 7LS1; -.
DR PDBsum; 7LS2; -.
DR AlphaFoldDB; P86048; -.
DR SMR; P86048; -.
DR BioGRID; 231958; 6.
DR IntAct; P86048; 1.
DR STRING; 10090.ENSMUSP00000100795; -.
DR iPTMnet; P86048; -.
DR PhosphoSitePlus; P86048; -.
DR SwissPalm; P86048; -.
DR jPOST; P86048; -.
DR MaxQB; P86048; -.
DR PaxDb; P86048; -.
DR PeptideAtlas; P86048; -.
DR PRIDE; P86048; -.
DR ProteomicsDB; 253134; -.
DR Antibodypedia; 23486; 143 antibodies from 23 providers.
DR Ensembl; ENSMUST00000081908; ENSMUSP00000100795; ENSMUSG00000060499.
DR GeneID; 238217; -.
DR KEGG; mmu:238217; -.
DR UCSC; uc011ymh.1; mouse.
DR CTD; 140801; -.
DR MGI; MGI:3647985; Rpl10l.
DR VEuPathDB; HostDB:ENSMUSG00000060499; -.
DR eggNOG; KOG0857; Eukaryota.
DR GeneTree; ENSGT00390000003897; -.
DR HOGENOM; CLU_084051_0_0_1; -.
DR InParanoid; P86048; -.
DR OMA; MSVRAKE; -.
DR OrthoDB; 1215841at2759; -.
DR PhylomeDB; P86048; -.
DR TreeFam; TF300082; -.
DR Reactome; R-MMU-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR Reactome; R-MMU-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR Reactome; R-MMU-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR Reactome; R-MMU-72689; Formation of a pool of free 40S subunits.
DR Reactome; R-MMU-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR Reactome; R-MMU-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR Reactome; R-MMU-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR BioGRID-ORCS; 238217; 0 hits in 70 CRISPR screens.
DR ChiTaRS; Rpl10l; mouse.
DR PRO; PR:P86048; -.
DR Proteomes; UP000000589; Chromosome 12.
DR RNAct; P86048; protein.
DR Bgee; ENSMUSG00000060499; Expressed in spermatocyte and 21 other tissues.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0022625; C:cytosolic large ribosomal subunit; IDA:MGI.
DR GO; GO:0005783; C:endoplasmic reticulum; ISO:MGI.
DR GO; GO:0005634; C:nucleus; ISO:MGI.
DR GO; GO:0005844; C:polysome; IDA:MGI.
DR GO; GO:0005840; C:ribosome; ISS:UniProtKB.
DR GO; GO:0003735; F:structural constituent of ribosome; IMP:UniProtKB.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007141; P:male meiosis I; IMP:UniProtKB.
DR GO; GO:0000027; P:ribosomal large subunit assembly; IMP:UniProtKB.
DR GO; GO:0007283; P:spermatogenesis; IMP:UniProtKB.
DR GO; GO:0006412; P:translation; IEA:InterPro.
DR CDD; cd01433; Ribosomal_L16_L10e; 1.
DR Gene3D; 3.90.1170.10; -; 1.
DR InterPro; IPR001197; Ribosomal_L10e.
DR InterPro; IPR016180; Ribosomal_L10e/L16.
DR InterPro; IPR036920; Ribosomal_L10e/L16_sf.
DR InterPro; IPR018255; Ribosomal_L10e_CS.
DR PANTHER; PTHR11726; PTHR11726; 1.
DR Pfam; PF00252; Ribosomal_L16; 1.
DR PIRSF; PIRSF005590; Ribosomal_L10; 1.
DR SUPFAM; SSF54686; SSF54686; 1.
DR TIGRFAMs; TIGR00279; uL16_euk_arch; 1.
DR PROSITE; PS01257; RIBOSOMAL_L10E; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cytoplasm; Differentiation; Meiosis; Reference proteome;
KW Ribonucleoprotein; Ribosomal protein; Spermatogenesis.
FT CHAIN 1..214
FT /note="60S ribosomal protein L10-like"
FT /id="PRO_0000354975"
SQ SEQUENCE 214 AA; 24558 MW; 57C0CEC8D87C729E CRC64;
MGRRPARCYR YCKNKPYPKS RFCRGVPDAK IRIFDLGRKK AKVDEFPLCG HMVSDEYEQL
SSEALEAARI CANKYMVKSC GKDGFHIRVR LHPFHVIRIN KMLSCAGADR LQTGMRGAFG
KPQGTVARVH IGQVIMSIRT KLQNKEHVIE ALRRAKFKFP GRQKIHISKK WGFTKFNADE
FEDKVAAKRL IPDGCGVKYI PERGPLDKWR ALHS
