ID   RL10_DANRE              Reviewed;         215 AA.
AC   Q7ZV96;
DT   22-NOV-2017, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 129.
DE   RecName: Full=60S ribosomal protein L10 {ECO:0000305};
DE   AltName: Full=Protein QM {ECO:0000303|Ref.1};
DE   AltName: Full=Ribosomal protein L10 {ECO:0000250|UniProtKB:P27635};
GN   Name=rpl10 {ECO:0000250|UniProtKB:P27635}; Synonyms=QM {ECO:0000303|Ref.1};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000312|EMBL:AAH45950.1};
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Jin H., Shao J., Xiang L.;
RT   "Electronic cloning and digital differential display analysis of Danio
RT   rerio QM gene by EST database searching.";
RL   Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   FUNCTION, DEVELOPMENTAL STAGE, AND DISRUPTION PHENOTYPE.
RX   PubMed=25316788; DOI=10.1534/genetics.114.168211;
RA   Brooks S.S., Wall A.L., Golzio C., Reid D.W., Kondyles A., Willer J.R.,
RA   Botti C., Nicchitta C.V., Katsanis N., Davis E.E.;
RT   "A novel ribosomopathy caused by dysfunction of RPL10 disrupts
RT   neurodevelopment and causes X-linked microcephaly in humans.";
RL   Genetics 198:723-733(2014).
CC   -!- FUNCTION: Component of the large ribosomal subunit (Probable). Plays a
CC       role in the formation of actively translating ribosomes
CC       (PubMed:25316788). Plays a role in the embryonic brain development
CC       (PubMed:25316788). {ECO:0000269|PubMed:25316788,
CC       ECO:0000305|PubMed:25316788}.
CC   -!- SUBUNIT: Component of the large ribosomal subunit.
CC       {ECO:0000305|PubMed:25316788}.
CC   -!- DEVELOPMENTAL STAGE: Expressed ubiquitously in the embryos. Strongly
CC       expressed at the midbrain and hindbrain boundary at 2 days post-
CC       fertilization (dpf). {ECO:0000269|PubMed:25316788}.
CC   -!- DISRUPTION PHENOTYPE: Morpholino knockdown of the protein decreases
CC       head size, but not body length at 2 days post-fertilization (dpf)
CC       (PubMed:25316788). Show decreased formation of actively translating
CC       ribosomes (PubMed:25316788). {ECO:0000269|PubMed:25316788}.
CC   -!- SIMILARITY: Belongs to the universal ribosomal protein uL16 family.
CC       {ECO:0000305}.
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DR   EMBL; AY763500; AAV34163.1; -; mRNA.
DR   EMBL; CR352234; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC045950; AAH45950.1; -; mRNA.
DR   EMBL; BC164313; AAI64313.1; -; mRNA.
DR   RefSeq; NP_956321.1; NM_200027.1.
DR   RefSeq; XP_017209012.1; XM_017353523.1.
DR   AlphaFoldDB; Q7ZV96; -.
DR   SMR; Q7ZV96; -.
DR   STRING; 7955.ENSDARP00000119262; -.
DR   PaxDb; Q7ZV96; -.
DR   PRIDE; Q7ZV96; -.
DR   Ensembl; ENSDART00000032744; ENSDARP00000036951; ENSDARG00000025581.
DR   Ensembl; ENSDART00000131860; ENSDARP00000120909; ENSDARG00000025581.
DR   Ensembl; ENSDART00000142072; ENSDARP00000119262; ENSDARG00000025581.
DR   Ensembl; ENSDART00000182714; ENSDARP00000145934; ENSDARG00000117015.
DR   Ensembl; ENSDART00000192800; ENSDARP00000149077; ENSDARG00000115128.
DR   GeneID; 336712; -.
DR   KEGG; dre:336712; -.
DR   CTD; 6134; -.
DR   ZFIN; ZDB-GENE-030131-8656; rpl10.
DR   eggNOG; KOG0857; Eukaryota.
DR   GeneTree; ENSGT00390000003897; -.
DR   HOGENOM; CLU_084051_0_1_1; -.
DR   InParanoid; Q7ZV96; -.
DR   OMA; HHVIREN; -.
DR   OrthoDB; 1215841at2759; -.
DR   PhylomeDB; Q7ZV96; -.
DR   TreeFam; TF300082; -.
DR   Reactome; R-DRE-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR   Reactome; R-DRE-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR   Reactome; R-DRE-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR   Reactome; R-DRE-72689; Formation of a pool of free 40S subunits.
DR   Reactome; R-DRE-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR   Reactome; R-DRE-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR   Reactome; R-DRE-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR   PRO; PR:Q7ZV96; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 23.
DR   Bgee; ENSDARG00000025581; Expressed in granulocyte and 25 other tissues.
DR   ExpressionAtlas; Q7ZV96; baseline and differential.
DR   GO; GO:0022625; C:cytosolic large ribosomal subunit; IBA:GO_Central.
DR   GO; GO:0003735; F:structural constituent of ribosome; IBA:GO_Central.
DR   GO; GO:0045182; F:translation regulator activity; IMP:UniProtKB.
DR   GO; GO:0007420; P:brain development; IMP:ZFIN.
DR   GO; GO:1990403; P:embryonic brain development; IMP:UniProtKB.
DR   GO; GO:0006417; P:regulation of translation; IMP:UniProtKB.
DR   GO; GO:0000027; P:ribosomal large subunit assembly; IBA:GO_Central.
DR   GO; GO:0006412; P:translation; IEA:InterPro.
DR   CDD; cd01433; Ribosomal_L16_L10e; 1.
DR   Gene3D; 3.90.1170.10; -; 1.
DR   InterPro; IPR001197; Ribosomal_L10e.
DR   InterPro; IPR016180; Ribosomal_L10e/L16.
DR   InterPro; IPR036920; Ribosomal_L10e/L16_sf.
DR   InterPro; IPR018255; Ribosomal_L10e_CS.
DR   PANTHER; PTHR11726; PTHR11726; 1.
DR   Pfam; PF00252; Ribosomal_L16; 1.
DR   PIRSF; PIRSF005590; Ribosomal_L10; 1.
DR   SUPFAM; SSF54686; SSF54686; 1.
DR   TIGRFAMs; TIGR00279; uL16_euk_arch; 1.
DR   PROSITE; PS01257; RIBOSOMAL_L10E; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; Reference proteome; Ribonucleoprotein;
KW   Ribosomal protein; Translation regulation.
FT   CHAIN           1..215
FT                   /note="60S ribosomal protein L10"
FT                   /id="PRO_0000442353"
SQ   SEQUENCE   215 AA;  24611 MW;  4C747E40ECFE34C2 CRC64;
     MGRRPARCYR YCKNKPYPKS RFCRGVPDPK IRIFDLGRKK AKVDEFPLCA HMVSDEYEQL
     SSEALEAARI CANKYMVKTC GKDGFHIRVR LHPFHVIRIN KMLSCAGADR LQTGMRGAFG
     KPQGTVARVH IGQVIMSVRT KAQNKEHVIE ALRRAKFKFP GRQKIHVSKK YGFTKFNTCD
     FDNMLAEKRL IPDGCGVKYI PSRGPLSRWK ALHAN