RL10_METBF
ID RL10_METBF Reviewed; 346 AA.
AC Q46EU9;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 13-SEP-2005, sequence version 1.
DT 25-MAY-2022, entry version 103.
DE RecName: Full=50S ribosomal protein L10 {ECO:0000255|HAMAP-Rule:MF_00280};
DE AltName: Full=Acidic ribosomal protein P0 homolog {ECO:0000255|HAMAP-Rule:MF_00280};
GN Name=rpl10 {ECO:0000255|HAMAP-Rule:MF_00280};
GN Synonyms=rplP0 {ECO:0000255|HAMAP-Rule:MF_00280};
GN OrderedLocusNames=Mbar_A0613;
OS Methanosarcina barkeri (strain Fusaro / DSM 804).
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanosarcinales; Methanosarcinaceae; Methanosarcina.
OX NCBI_TaxID=269797;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Fusaro / DSM 804;
RX PubMed=16980466; DOI=10.1128/jb.00810-06;
RA Maeder D.L., Anderson I., Brettin T.S., Bruce D.C., Gilna P., Han C.S.,
RA Lapidus A., Metcalf W.W., Saunders E., Tapia R., Sowers K.R.;
RT "The Methanosarcina barkeri genome: comparative analysis with
RT Methanosarcina acetivorans and Methanosarcina mazei reveals extensive
RT rearrangement within methanosarcinal genomes.";
RL J. Bacteriol. 188:7922-7931(2006).
RN [2]
RP SUBUNIT, STOICHIOMETRY, AND MASS SPECTROMETRY.
RX PubMed=20467040; DOI=10.1074/mcp.m000072-mcp201;
RA Gordiyenko Y., Videler H., Zhou M., McKay A.R., Fucini P., Biegel E.,
RA Muller V., Robinson C.V.;
RT "Mass spectrometry defines the stoichiometry of ribosomal stalk complexes
RT across the phylogenetic tree.";
RL Mol. Cell. Proteomics 9:1774-1783(2010).
CC -!- FUNCTION: Forms part of the ribosomal stalk, playing a central role in
CC the interaction of the ribosome with GTP-bound translation factors.
CC {ECO:0000255|HAMAP-Rule:MF_00280}.
CC -!- SUBUNIT: Part of the 50S ribosomal subunit. Forms part of the ribosomal
CC stalk which helps the ribosome interact with GTP-bound translation
CC factors. Forms both a pentameric L10(L12)2(L12)2 and heptameric
CC L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to
CC which the L12 dimers bind in a sequential fashion. The proportion of
CC heptameric complexes increases during cell growth.
CC {ECO:0000269|PubMed:20467040}.
CC -!- MASS SPECTROMETRY: Mass=101650.02; Mass_error=30.7;
CC Method=Electrospray; Note=Isolated L10(L12)6.;
CC Evidence={ECO:0000269|PubMed:20467040};
CC -!- MASS SPECTROMETRY: Mass=80124.39; Mass_error=18.0; Method=Electrospray;
CC Note=Isolated L10(L12)4.; Evidence={ECO:0000269|PubMed:20467040};
CC -!- SIMILARITY: Belongs to the universal ribosomal protein uL10 family.
CC {ECO:0000255|HAMAP-Rule:MF_00280}.
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DR EMBL; CP000099; AAZ69593.1; -; Genomic_DNA.
DR RefSeq; WP_011305644.1; NC_007355.1.
DR AlphaFoldDB; Q46EU9; -.
DR SMR; Q46EU9; -.
DR STRING; 269797.Mbar_A0613; -.
DR EnsemblBacteria; AAZ69593; AAZ69593; Mbar_A0613.
DR GeneID; 3627673; -.
DR KEGG; mba:Mbar_A0613; -.
DR eggNOG; arCOG04288; Archaea.
DR HOGENOM; CLU_053173_0_0_2; -.
DR OMA; MAHVAEW; -.
DR OrthoDB; 73593at2157; -.
DR GO; GO:0005840; C:ribosome; IEA:UniProtKB-KW.
DR GO; GO:0070180; F:large ribosomal subunit rRNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006412; P:translation; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.70.1730; -; 1.
DR Gene3D; 3.90.105.20; -; 1.
DR HAMAP; MF_00280; Ribosomal_L10_arch; 1.
DR InterPro; IPR022909; 50S_L10_arch.
DR InterPro; IPR043141; Ribosomal_L10-like_sf.
DR InterPro; IPR001790; Ribosomal_L10P.
DR InterPro; IPR043164; RL10_insert_sf.
DR InterPro; IPR040637; RL10P_insert.
DR Pfam; PF00466; Ribosomal_L10; 1.
DR Pfam; PF17777; RL10P_insert; 1.
DR SUPFAM; SSF160369; SSF160369; 1.
PE 1: Evidence at protein level;
KW Ribonucleoprotein; Ribosomal protein; RNA-binding; rRNA-binding.
FT CHAIN 1..346
FT /note="50S ribosomal protein L10"
FT /id="PRO_1000006786"
FT REGION 307..346
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 320..335
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 346 AA; 37332 MW; 136B7EE72A436485 CRC64;
MEEEKHHTEH VPEWKKDEIE NIMELIQSHK VFGMVGIEGI LATKIQKIRR DLKDVAVLKV
SRNSLTERAL NQLGESIPEM NKYLDKQTAL VFTNESPFKL YKVLEQTKTP SPIKGGAIAP
ADIIVQKGPT SFPPGPILGE LQSAGIPASI DAGKVAVKET KVVCKAGEVV SQKLATMLTK
LEIYPLIVGL DLRAVYDNGA IYEPELLAID ESQYFSDITR AAQSAFNLAV NTAYPTSATI
GTLLAKAFAE SKNLGVNAVV FDSGVMDALL AKAHVQMTSV ASEAADKDAN AVDDQLREVL
GAAASAAAAV AKEPEKKEEV KEEEEEEEEE DHSEEDGMAG LGSLFG
