RL10_METJA
ID RL10_METJA Reviewed; 338 AA.
AC P54049;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 15-JUL-1998, sequence version 2.
DT 25-MAY-2022, entry version 116.
DE RecName: Full=50S ribosomal protein L10 {ECO:0000255|HAMAP-Rule:MF_00280};
DE AltName: Full=Acidic ribosomal protein P0 homolog {ECO:0000255|HAMAP-Rule:MF_00280};
DE AltName: Full=MjaL10;
GN Name=rpl10 {ECO:0000255|HAMAP-Rule:MF_00280};
GN Synonyms=rplP0 {ECO:0000255|HAMAP-Rule:MF_00280}; OrderedLocusNames=MJ0509;
OS Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM
OS 10045 / NBRC 100440) (Methanococcus jannaschii).
OC Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC Methanocaldococcaceae; Methanocaldococcus.
OX NCBI_TaxID=243232;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
RX PubMed=8688087; DOI=10.1126/science.273.5278.1058;
RA Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G.,
RA Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R.,
RA Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R.,
RA Kirkness E.F., Weinstock K.G., Merrick J.M., Glodek A., Scott J.L.,
RA Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R.,
RA Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D.,
RA Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P.,
RA Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
RT "Complete genome sequence of the methanogenic archaeon, Methanococcus
RT jannaschii.";
RL Science 273:1058-1073(1996).
RN [2]
RP X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS) OF 10-221.
RX PubMed=20399793; DOI=10.1016/j.jmb.2010.04.017;
RA Kravchenko O., Mitroshin I., Nikonov S., Piendl W., Garber M.;
RT "Structure of a two-domain N-terminal fragment of ribosomal protein L10
RT from Methanococcus jannaschii reveals a specific piece of the archaeal
RT ribosomal stalk.";
RL J. Mol. Biol. 399:214-220(2010).
CC -!- FUNCTION: Forms part of the ribosomal stalk, playing a central role in
CC the interaction of the ribosome with GTP-bound translation factors.
CC {ECO:0000305}.
CC -!- SUBUNIT: Part of the 50S ribosomal subunit. Forms part of the ribosomal
CC stalk which helps the ribosome interact with GTP-bound translation
CC factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10
CC forms an elongated spine to which the L12 dimers bind in a sequential
CC fashion (Probable). {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the universal ribosomal protein uL10 family.
CC {ECO:0000255|HAMAP-Rule:MF_00280}.
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DR EMBL; L77117; AAB98499.1; -; Genomic_DNA.
DR RefSeq; WP_010870010.1; NC_000909.1.
DR PDB; 3JSY; X-ray; 1.60 A; A/B=10-221.
DR PDB; 5D6G; X-ray; 3.30 A; A=10-221.
DR PDB; 5D8H; X-ray; 2.80 A; B=9-221.
DR PDB; 5DAR; X-ray; 2.90 A; B/E=10-221.
DR PDBsum; 3JSY; -.
DR PDBsum; 5D6G; -.
DR PDBsum; 5D8H; -.
DR PDBsum; 5DAR; -.
DR AlphaFoldDB; P54049; -.
DR SMR; P54049; -.
DR STRING; 243232.MJ_0509; -.
DR EnsemblBacteria; AAB98499; AAB98499; MJ_0509.
DR GeneID; 1451371; -.
DR KEGG; mja:MJ_0509; -.
DR eggNOG; arCOG04288; Archaea.
DR HOGENOM; CLU_053173_0_0_2; -.
DR InParanoid; P54049; -.
DR OMA; MAHVAEW; -.
DR OrthoDB; 73593at2157; -.
DR PhylomeDB; P54049; -.
DR EvolutionaryTrace; P54049; -.
DR Proteomes; UP000000805; Chromosome.
DR GO; GO:0022625; C:cytosolic large ribosomal subunit; IBA:GO_Central.
DR GO; GO:0070180; F:large ribosomal subunit rRNA binding; IBA:GO_Central.
DR GO; GO:0003735; F:structural constituent of ribosome; IBA:GO_Central.
DR GO; GO:0002181; P:cytoplasmic translation; IBA:GO_Central.
DR GO; GO:0000027; P:ribosomal large subunit assembly; IBA:GO_Central.
DR Gene3D; 3.30.70.1730; -; 1.
DR Gene3D; 3.90.105.20; -; 1.
DR HAMAP; MF_00280; Ribosomal_L10_arch; 1.
DR InterPro; IPR022909; 50S_L10_arch.
DR InterPro; IPR043141; Ribosomal_L10-like_sf.
DR InterPro; IPR001790; Ribosomal_L10P.
DR InterPro; IPR043164; RL10_insert_sf.
DR InterPro; IPR040637; RL10P_insert.
DR Pfam; PF00466; Ribosomal_L10; 1.
DR Pfam; PF17777; RL10P_insert; 1.
DR SUPFAM; SSF160369; SSF160369; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Reference proteome; Ribonucleoprotein; Ribosomal protein;
KW RNA-binding; rRNA-binding.
FT CHAIN 1..338
FT /note="50S ribosomal protein L10"
FT /id="PRO_0000154793"
FT REGION 303..338
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 309..330
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT HELIX 11..26
FT /evidence="ECO:0007829|PDB:3JSY"
FT STRAND 27..34
FT /evidence="ECO:0007829|PDB:3JSY"
FT HELIX 40..50
FT /evidence="ECO:0007829|PDB:3JSY"
FT TURN 51..53
FT /evidence="ECO:0007829|PDB:3JSY"
FT STRAND 54..58
FT /evidence="ECO:0007829|PDB:3JSY"
FT HELIX 61..74
FT /evidence="ECO:0007829|PDB:3JSY"
FT HELIX 78..86
FT /evidence="ECO:0007829|PDB:3JSY"
FT STRAND 89..98
FT /evidence="ECO:0007829|PDB:3JSY"
FT HELIX 100..109
FT /evidence="ECO:0007829|PDB:3JSY"
FT STRAND 112..114
FT /evidence="ECO:0007829|PDB:3JSY"
FT STRAND 126..128
FT /evidence="ECO:0007829|PDB:3JSY"
FT STRAND 130..132
FT /evidence="ECO:0007829|PDB:3JSY"
FT HELIX 140..146
FT /evidence="ECO:0007829|PDB:3JSY"
FT STRAND 151..154
FT /evidence="ECO:0007829|PDB:3JSY"
FT STRAND 157..160
FT /evidence="ECO:0007829|PDB:3JSY"
FT STRAND 164..167
FT /evidence="ECO:0007829|PDB:3JSY"
FT STRAND 169..171
FT /evidence="ECO:0007829|PDB:5D6G"
FT HELIX 175..183
FT /evidence="ECO:0007829|PDB:3JSY"
FT STRAND 189..192
FT /evidence="ECO:0007829|PDB:3JSY"
FT STRAND 194..200
FT /evidence="ECO:0007829|PDB:3JSY"
FT STRAND 203..205
FT /evidence="ECO:0007829|PDB:3JSY"
FT HELIX 207..213
FT /evidence="ECO:0007829|PDB:3JSY"
SQ SEQUENCE 338 AA; 36751 MW; 63A6AFD357E3052D CRC64;
METKVKAHVA PWKIEEVKTL KGLIKSKPVV AIVDMMDVPA PQLQEIRDKI RDKVKLRMSR
NTLIIRALKE AAEELNNPKL AELANYVERG AAILVTDMNP FKLYKLLEEN KSPAPVRGGQ
IAPCDIKVEK GSTGMPPGPF LGELKSVGIP AAIEKGKIAI KEDKVVVKKG EVVSPKLAAV
LDRLGIKPIK VGLNILAVYE DGIIYTPDVL KVDEEKLLAD IQAAYQNAFN LAFNTAYPAK
EVLPFLIQKA FINARALSVE TAFVTKETAG DILAKAQAQA LALASKLPDE ALDEDIKAKL
SSVEVSAAPA AEEEKEEEKK EEEKKEEDTG AAGLALLF