RL10_PIG
ID RL10_PIG Reviewed; 214 AA.
AC Q29195; Q29322; Q2YGT8;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=60S ribosomal protein L10 {ECO:0000305};
DE AltName: Full=Protein QM homolog;
DE AltName: Full=Ribosomal protein L10 {ECO:0000250|UniProtKB:P27635};
GN Name=RPL10 {ECO:0000250|UniProtKB:P27635}; Synonyms=QM;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Wang H.L., Zhu Z.M., Wu X., Wang H., Yu M., Zhao S.H., Yang S.L., Li K.;
RT "Full-length cDNA, molecular characterization, and physical mapping of
RT porcine RPL6, RPL7 and RPL10.";
RL Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-71 AND 101-213.
RC TISSUE=Small intestine;
RX PubMed=8672129; DOI=10.1007/s003359900153;
RA Winteroe A.K., Fredholm M., Davies W.;
RT "Evaluation and characterization of a porcine small intestine cDNA library:
RT analysis of 839 clones.";
RL Mamm. Genome 7:509-517(1996).
CC -!- FUNCTION: Component of the large ribosomal subunit. Plays a role in the
CC formation of actively translating ribosomes. May play a role in the
CC embryonic brain development. {ECO:0000250|UniProtKB:P27635}.
CC -!- SUBUNIT: Component of the large ribosomal subunit. Mature ribosomes
CC consist of a small (40S) and a large (60S) subunit. The 40S subunit
CC contains about 33 different proteins and 1 molecule of RNA (18S). The
CC 60S subunit contains about 49 different proteins and 3 molecules of RNA
CC (28S, 5.8S and 5S). {ECO:0000250|UniProtKB:P27635}.
CC -!- PTM: Citrullinated by PADI4. {ECO:0000250|UniProtKB:Q6ZWV3}.
CC -!- PTM: Ufmylated by UFL1. {ECO:0000250|UniProtKB:Q6ZWV3}.
CC -!- SIMILARITY: Belongs to the universal ribosomal protein uL16 family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA23208.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AY735455; AAV85773.1; -; mRNA.
DR EMBL; F14723; CAA23208.1; ALT_INIT; mRNA.
DR EMBL; F14513; CAA23099.1; -; mRNA.
DR RefSeq; NP_001038008.1; NM_001044543.1.
DR PDB; 3J7O; EM; 3.40 A; I=2-214.
DR PDB; 3J7P; EM; 3.50 A; I=2-214.
DR PDB; 3J7Q; EM; 3.50 A; I=2-214.
DR PDB; 3J7R; EM; 3.90 A; I=2-214.
DR PDBsum; 3J7O; -.
DR PDBsum; 3J7P; -.
DR PDBsum; 3J7Q; -.
DR PDBsum; 3J7R; -.
DR AlphaFoldDB; Q29195; -.
DR SMR; Q29195; -.
DR PaxDb; Q29195; -.
DR PeptideAtlas; Q29195; -.
DR PRIDE; Q29195; -.
DR Ensembl; ENSSSCT00000089173; ENSSSCP00000060715; ENSSSCG00000035997.
DR Ensembl; ENSSSCT00005012576; ENSSSCP00005007415; ENSSSCG00005008194.
DR Ensembl; ENSSSCT00030018037; ENSSSCP00030008010; ENSSSCG00030013154.
DR Ensembl; ENSSSCT00035065804; ENSSSCP00035026695; ENSSSCG00035049337.
DR Ensembl; ENSSSCT00040075181; ENSSSCP00040032264; ENSSSCG00040055315.
DR Ensembl; ENSSSCT00060048811; ENSSSCP00060020889; ENSSSCG00060035998.
DR Ensembl; ENSSSCT00065015009; ENSSSCP00065006120; ENSSSCG00065011221.
DR GeneID; 733593; -.
DR KEGG; ssc:733593; -.
DR CTD; 6134; -.
DR eggNOG; KOG0857; Eukaryota.
DR GeneTree; ENSGT00390000003897; -.
DR InParanoid; Q29195; -.
DR OMA; HHVIREN; -.
DR OrthoDB; 1215841at2759; -.
DR Proteomes; UP000008227; Chromosome X.
DR Proteomes; UP000314985; Unplaced.
DR Bgee; ENSSSCG00000035997; Expressed in granulosa cell and 41 other tissues.
DR ExpressionAtlas; Q29195; baseline.
DR GO; GO:0098556; C:cytoplasmic side of rough endoplasmic reticulum membrane; IDA:UniProtKB.
DR GO; GO:0022625; C:cytosolic large ribosomal subunit; ISS:UniProtKB.
DR GO; GO:0015934; C:large ribosomal subunit; IDA:UniProtKB.
DR GO; GO:0003735; F:structural constituent of ribosome; ISS:UniProtKB.
DR GO; GO:0045182; F:translation regulator activity; ISS:UniProtKB.
DR GO; GO:1990403; P:embryonic brain development; ISS:UniProtKB.
DR GO; GO:0006417; P:regulation of translation; ISS:UniProtKB.
DR GO; GO:0000027; P:ribosomal large subunit assembly; IBA:GO_Central.
DR GO; GO:0006412; P:translation; IEA:InterPro.
DR CDD; cd01433; Ribosomal_L16_L10e; 1.
DR Gene3D; 3.90.1170.10; -; 1.
DR InterPro; IPR001197; Ribosomal_L10e.
DR InterPro; IPR016180; Ribosomal_L10e/L16.
DR InterPro; IPR036920; Ribosomal_L10e/L16_sf.
DR InterPro; IPR018255; Ribosomal_L10e_CS.
DR PANTHER; PTHR11726; PTHR11726; 1.
DR Pfam; PF00252; Ribosomal_L16; 1.
DR PIRSF; PIRSF005590; Ribosomal_L10; 1.
DR SUPFAM; SSF54686; SSF54686; 1.
DR TIGRFAMs; TIGR00279; uL16_euk_arch; 1.
DR PROSITE; PS01257; RIBOSOMAL_L10E; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Citrullination; Developmental protein; Isopeptide bond;
KW Reference proteome; Ribonucleoprotein; Ribosomal protein;
KW Translation regulation; Ubl conjugation.
FT CHAIN 1..214
FT /note="60S ribosomal protein L10"
FT /id="PRO_0000147108"
FT MOD_RES 32
FT /note="Citrulline"
FT /evidence="ECO:0000250|UniProtKB:Q6ZWV3"
FT CROSSLNK 175
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:P27635"
FT CROSSLNK 188
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in ubiquitin)"
FT /evidence="ECO:0000250|UniProtKB:P27635"
FT CONFLICT 112..115
FT /note="QTGM -> PTRH (in Ref. 2; CAA23099)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 214 AA; 24603 MW; E6802ECC91DF74F4 CRC64;
MGRRPARCYR YCKNKPYPKS RFCRGVPDAK IRIFDLGRKK AKVDEFPLCG HMVSDEYEQL
SSEALEAARI CANKYMVKSC GKDGFHIRVR LHPFHVIRIN KMLSCAGADR LQTGMRGAFG
KPQGTVARVH IGQVIMSIRT KLQNKEHVIE ALRRAKFKFP GRQKIHISKK WGFTKFNADE
FENMVAEKRL IPDGCGVKYI PNRGPLDKWR ALHS
