ID   RL10_PYRFU              Reviewed;         339 AA.
AC   Q8TZJ8;
DT   13-AUG-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   25-MAY-2022, entry version 97.
DE   RecName: Full=50S ribosomal protein L10 {ECO:0000255|HAMAP-Rule:MF_00280};
DE   AltName: Full=Acidic ribosomal protein P0 homolog {ECO:0000255|HAMAP-Rule:MF_00280};
DE   AltName: Full=Large ribosomal subunit protein uL10;
GN   Name=rpl10 {ECO:0000255|HAMAP-Rule:MF_00280};
GN   Synonyms=rplP0 {ECO:0000255|HAMAP-Rule:MF_00280}; OrderedLocusNames=PF1993;
OS   Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1).
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Pyrococcus.
OX   NCBI_TaxID=186497;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43587 / DSM 3638 / JCM 8422 / Vc1;
RX   PubMed=10430560; DOI=10.1093/genetics/152.4.1299;
RA   Maeder D.L., Weiss R.B., Dunn D.M., Cherry J.L., Gonzalez J.M.,
RA   DiRuggiero J., Robb F.T.;
RT   "Divergence of the hyperthermophilic archaea Pyrococcus furiosus and P.
RT   horikoshii inferred from complete genomic sequences.";
RL   Genetics 152:1299-1305(1999).
RN   [2] {ECO:0007744|PDB:4V6U}
RP   STRUCTURE BY ELECTRON MICROSCOPY (6.60 ANGSTROMS) IN THE 70S RIBOSOME, AND
RP   SUBUNIT.
RX   PubMed=23222135; DOI=10.1093/nar/gks1259;
RA   Armache J.P., Anger A.M., Marquez V., Franckenberg S., Frohlich T.,
RA   Villa E., Berninghausen O., Thomm M., Arnold G.J., Beckmann R.,
RA   Wilson D.N.;
RT   "Promiscuous behaviour of archaeal ribosomal proteins: implications for
RT   eukaryotic ribosome evolution.";
RL   Nucleic Acids Res. 41:1284-1293(2013).
CC   -!- FUNCTION: Forms part of the ribosomal stalk, playing a central role in
CC       the interaction of the ribosome with GTP-bound translation factors.
CC       {ECO:0000255|HAMAP-Rule:MF_00280}.
CC   -!- SUBUNIT: Part of the 50S ribosomal subunit (PubMed:23222135). Forms
CC       part of the ribosomal stalk which helps the ribosome interact with GTP-
CC       bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2
CC       complex, where L10 forms an elongated spine to which the L12 dimers
CC       bind in a sequential fashion. {ECO:0000255|HAMAP-Rule:MF_00280,
CC       ECO:0000269|PubMed:23222135}.
CC   -!- SIMILARITY: Belongs to the universal ribosomal protein uL10 family.
CC       {ECO:0000255|HAMAP-Rule:MF_00280}.
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DR   EMBL; AE009950; AAL82117.1; -; Genomic_DNA.
DR   RefSeq; WP_011013137.1; NZ_CP023154.1.
DR   PDB; 4V6U; EM; 6.60 A; Bk=1-339.
DR   PDBsum; 4V6U; -.
DR   AlphaFoldDB; Q8TZJ8; -.
DR   SMR; Q8TZJ8; -.
DR   STRING; 186497.PF1993; -.
DR   EnsemblBacteria; AAL82117; AAL82117; PF1993.
DR   GeneID; 41713816; -.
DR   KEGG; pfu:PF1993; -.
DR   PATRIC; fig|186497.12.peg.2069; -.
DR   eggNOG; arCOG04288; Archaea.
DR   HOGENOM; CLU_053173_0_0_2; -.
DR   OMA; MAHVAEW; -.
DR   OrthoDB; 73593at2157; -.
DR   PhylomeDB; Q8TZJ8; -.
DR   Proteomes; UP000001013; Chromosome.
DR   GO; GO:0005840; C:ribosome; IEA:UniProtKB-KW.
DR   GO; GO:0070180; F:large ribosomal subunit rRNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006412; P:translation; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.70.1730; -; 1.
DR   Gene3D; 3.90.105.20; -; 1.
DR   HAMAP; MF_00280; Ribosomal_L10_arch; 1.
DR   InterPro; IPR022909; 50S_L10_arch.
DR   InterPro; IPR043141; Ribosomal_L10-like_sf.
DR   InterPro; IPR001790; Ribosomal_L10P.
DR   InterPro; IPR043164; RL10_insert_sf.
DR   InterPro; IPR040637; RL10P_insert.
DR   Pfam; PF00466; Ribosomal_L10; 1.
DR   Pfam; PF17777; RL10P_insert; 1.
DR   SUPFAM; SSF160369; SSF160369; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Reference proteome; Ribonucleoprotein; Ribosomal protein;
KW   RNA-binding; rRNA-binding.
FT   CHAIN           1..339
FT                   /note="50S ribosomal protein L10"
FT                   /id="PRO_0000154803"
FT   REGION          307..339
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        315..329
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   339 AA;  37129 MW;  5724A0E7BD88D800 CRC64;
     MAHVAEWKKK EVEELANLIK SYPVVALVDV SSMPAYPLSQ MRRLIRENNG LLRVSRNTLI
     ELAIKKVAQE LGKPELEKLI NYIEGGAGIL VTTMNPFKLY KFLQQNRQPA PAKPGAKVPK
     DVVIPAGPTS LAPGPIVGQM QAMGIPARIE RGKVTIQKDT VVLKAGEEIT PELANILNAL
     GIQPLEVGLD LLAVYEDGII YTPDVLAIDE SEYINMLQKA YMHAFNLAVN IAYPTPQTIE
     AIIQKAFLNA KAVAVEAGYI TKETISDIIG RAIRAMLLLA QQLPEDVLDE KTKELLSAQA
     QVSVAQVEEE KKEEKVEEEK EDEEASEEEA LAGLSALFG