RL10_RAT
ID RL10_RAT Reviewed; 214 AA.
AC Q6PDV7; P45634;
DT 19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=60S ribosomal protein L10 {ECO:0000305};
DE AltName: Full=Ribosomal protein L10 {ECO:0000312|RGD:621178};
GN Name=Rpl10 {ECO:0000312|RGD:621178};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 2-29.
RC STRAIN=Sprague-Dawley; TISSUE=Liver;
RX PubMed=8780716; DOI=10.1006/bbrc.1996.1277;
RA Chan Y.-L., Diaz J.-J., Denoroy L., Madjar J.-J., Wool I.G.;
RT "The primary structure of rat ribosomal protein L10: relationship to a Jun-
RT binding protein and to a putative Wilms' tumor suppressor.";
RL Biochem. Biophys. Res. Commun. 225:952-956(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Pituitary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Component of the large ribosomal subunit. Plays a role in the
CC formation of actively translating ribosomes. May play a role in the
CC embryonic brain development. {ECO:0000250|UniProtKB:P27635}.
CC -!- SUBUNIT: Component of the large ribosomal subunit. Mature ribosomes
CC consist of a small (40S) and a large (60S) subunit. The 40S subunit
CC contains about 33 different proteins and 1 molecule of RNA (18S). The
CC 60S subunit contains about 49 different proteins and 3 molecules of RNA
CC (28S, 5.8S and 5S). {ECO:0000250|UniProtKB:P27635}.
CC -!- PTM: Citrullinated by PADI4. {ECO:0000250|UniProtKB:Q6ZWV3}.
CC -!- PTM: Ufmylated by UFL1. {ECO:0000250|UniProtKB:Q6ZWV3}.
CC -!- SIMILARITY: Belongs to the universal ribosomal protein uL16 family.
CC {ECO:0000305}.
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DR EMBL; X87106; CAA60587.1; -; mRNA.
DR EMBL; BC058467; AAH58467.1; -; mRNA.
DR PIR; JC4911; JC4911.
DR RefSeq; NP_112362.1; NM_031100.1.
DR AlphaFoldDB; Q6PDV7; -.
DR SMR; Q6PDV7; -.
DR BioGRID; 249636; 1.
DR IntAct; Q6PDV7; 2.
DR STRING; 10116.ENSRNOP00000053123; -.
DR iPTMnet; Q6PDV7; -.
DR PhosphoSitePlus; Q6PDV7; -.
DR jPOST; Q6PDV7; -.
DR PaxDb; Q6PDV7; -.
DR PRIDE; Q6PDV7; -.
DR Ensembl; ENSRNOT00000083951; ENSRNOP00000070105; ENSRNOG00000056765.
DR GeneID; 81764; -.
DR KEGG; rno:81764; -.
DR CTD; 6134; -.
DR RGD; 621178; Rpl10.
DR eggNOG; KOG0857; Eukaryota.
DR GeneTree; ENSGT00390000003897; -.
DR HOGENOM; CLU_084051_0_0_1; -.
DR InParanoid; Q6PDV7; -.
DR OMA; HHVIREN; -.
DR OrthoDB; 1215841at2759; -.
DR PhylomeDB; Q6PDV7; -.
DR TreeFam; TF300082; -.
DR Reactome; R-RNO-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR Reactome; R-RNO-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR Reactome; R-RNO-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR Reactome; R-RNO-72689; Formation of a pool of free 40S subunits.
DR Reactome; R-RNO-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR Reactome; R-RNO-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR Reactome; R-RNO-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR PRO; PR:Q6PDV7; -.
DR Proteomes; UP000002494; Chromosome X.
DR Bgee; ENSRNOG00000056765; Expressed in ovary and 20 other tissues.
DR Genevisible; Q6PDV7; RN.
DR GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR GO; GO:0022625; C:cytosolic large ribosomal subunit; IDA:RGD.
DR GO; GO:0022626; C:cytosolic ribosome; ISO:RGD.
DR GO; GO:0005634; C:nucleus; ISO:RGD.
DR GO; GO:0032991; C:protein-containing complex; ISO:RGD.
DR GO; GO:0045202; C:synapse; ISO:RGD.
DR GO; GO:0003735; F:structural constituent of ribosome; ISS:UniProtKB.
DR GO; GO:0045182; F:translation regulator activity; ISS:UniProtKB.
DR GO; GO:1990403; P:embryonic brain development; ISS:UniProtKB.
DR GO; GO:0097421; P:liver regeneration; IEP:RGD.
DR GO; GO:0043066; P:negative regulation of apoptotic process; ISO:RGD.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISO:RGD.
DR GO; GO:0006417; P:regulation of translation; ISS:UniProtKB.
DR GO; GO:0000027; P:ribosomal large subunit assembly; IBA:GO_Central.
DR GO; GO:0006412; P:translation; IEA:InterPro.
DR CDD; cd01433; Ribosomal_L16_L10e; 1.
DR Gene3D; 3.90.1170.10; -; 1.
DR InterPro; IPR001197; Ribosomal_L10e.
DR InterPro; IPR016180; Ribosomal_L10e/L16.
DR InterPro; IPR036920; Ribosomal_L10e/L16_sf.
DR InterPro; IPR018255; Ribosomal_L10e_CS.
DR PANTHER; PTHR11726; PTHR11726; 1.
DR Pfam; PF00252; Ribosomal_L16; 1.
DR PIRSF; PIRSF005590; Ribosomal_L10; 1.
DR SUPFAM; SSF54686; SSF54686; 1.
DR TIGRFAMs; TIGR00279; uL16_euk_arch; 1.
DR PROSITE; PS01257; RIBOSOMAL_L10E; 1.
PE 1: Evidence at protein level;
KW Citrullination; Developmental protein; Direct protein sequencing;
KW Isopeptide bond; Reference proteome; Ribonucleoprotein; Ribosomal protein;
KW Translation regulation; Ubl conjugation.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000269|PubMed:8780716"
FT CHAIN 2..214
FT /note="60S ribosomal protein L10"
FT /id="PRO_0000147110"
FT MOD_RES 32
FT /note="Citrulline"
FT /evidence="ECO:0000250|UniProtKB:Q6ZWV3"
FT CROSSLNK 175
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:P27635"
FT CROSSLNK 188
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in ubiquitin)"
FT /evidence="ECO:0000250|UniProtKB:P27635"
SQ SEQUENCE 214 AA; 24604 MW; 0860CECC91DF74FE CRC64;
MGRRPARCYR YCKNKPYPKS RFCRGVPDAK IRIFDLGRKK AKVDEFPLCG HMVSDEYEQL
SSEALEAARI CANKYMVKSC GKDGFHIRVR LHPFHVIRIN KMLSCAGADR LQTGMRGAFG
KPQGTVARVH IGQVIMSIRT KLQNKEHVIE ALRRAKFKFP GRQKIHISKK WGFTKFNADE
FEDMVAEKRL IPDGCGVKYI PNRGPLDKWR ALHS
