ID   RL114_PLAVT             Reviewed;         556 AA.
AC   P0CV45;
DT   18-SEP-2019, integrated into UniProtKB/Swiss-Prot.
DT   18-SEP-2019, sequence version 1.
DT   25-MAY-2022, entry version 10.
DE   RecName: Full=Secreted RxLR effector protein 114 {ECO:0000303|PubMed:29706971};
DE   Flags: Precursor;
GN   Name=RXLR114 {ECO:0000303|PubMed:29706971};
OS   Plasmopara viticola (Downy mildew of grapevine) (Botrytis viticola).
OC   Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC   Plasmopara.
OX   NCBI_TaxID=143451;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], DOMAIN, FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=29706971; DOI=10.3389/fpls.2018.00286;
RA   Liu Y., Lan X., Song S., Yin L., Dry I.B., Qu J., Xiang J., Lu J.;
RT   "In planta functional analysis and subcellular localization of the oomycete
RT   pathogen Plasmopara viticola candidate RXLR effector repertoire.";
RL   Front. Plant Sci. 9:286-286(2018).
CC   -!- FUNCTION: Secreted effector that partially suppresses the host cell
CC       death induced by cell death-inducing proteins.
CC       {ECO:0000269|PubMed:29706971}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:29706971}. Host cell
CC       {ECO:0000305|PubMed:29706971}.
CC   -!- DOMAIN: The RxLR-dEER motif acts to carry the protein into the host
CC       cell cytoplasm through binding to cell surface phosphatidylinositol-3-
CC       phosphate. {ECO:0000305|PubMed:29706971}.
CC   -!- SIMILARITY: Belongs to the RxLR effector family. {ECO:0000305}.
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DR   AlphaFoldDB; P0CV45; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0043657; C:host cell; IEA:UniProtKB-SubCell.
PE   2: Evidence at transcript level;
KW   Secreted; Signal; Virulence.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..556
FT                   /note="Secreted RxLR effector protein 114"
FT                   /id="PRO_0000447954"
FT   REGION          43..76
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          108..138
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          389..408
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           46..66
FT                   /note="RxLR-dEER"
FT                   /evidence="ECO:0000305|PubMed:29706971"
FT   COMPBIAS        46..63
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   556 AA;  62062 MW;  D84665D0439DE6F1 CRC64;
     MCGAHFVAIA LLVAAGCQTA AEFDQDDIQQ TSKDDSMASI DLLQSRNLRE SRDSKDDLLS
     AGDEERTPPF PSGVLKEPKV ADSTMAAANV MRTEGEASAI KAASKNLNQL KSNKPQRIAP
     ASRSVAGQVL HSSPDSDKSL VSVENEQLLV LAKRRRTKHP TAMMTNAVRS AEQHDYRLAP
     TESSTLPAQA SDGQLSKQLI TQKVLQLDKK KHVDESLWRE ELMTVDEVLH LLETFDKPAH
     PTAVNVHEAN AIGIATKKLN YLRRNKRKRI APTSNNVVGQ VPHAQPDPDK SPVLVAKDIP
     SVLAKRLRTD HPTAIMENAA RFVTQHNYRL APTGPSTIIA ATPNSQLKYH LPGQKALHLD
     KNEHAGDLKS LRNEESHTIE HILHLRERND KSAHTTAENH QSVPEDWNTV SAKGPKLLSK
     DSINEKVKKV HAAFVEAFNL PFHQYPEETA MMLKLVQRKT KSSPNNGETY DAFMYMAELQ
     QHSSHLRKLL GPDLKMLLGT DKTVLPIKLE NLQEAYNVKL VIMYDLFFEF CHDRKDLVEG
     LPRKPKPNQW ILKLST