ID   RL118_PLAVT             Reviewed;         382 AA.
AC   P0CV48;
DT   18-SEP-2019, integrated into UniProtKB/Swiss-Prot.
DT   18-SEP-2019, sequence version 1.
DT   25-MAY-2022, entry version 8.
DE   RecName: Full=Secreted RxLR effector protein 118 {ECO:0000303|PubMed:29706971};
DE   Flags: Precursor;
GN   Name=RXLR118 {ECO:0000303|PubMed:29706971};
OS   Plasmopara viticola (Downy mildew of grapevine) (Botrytis viticola).
OC   Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC   Plasmopara.
OX   NCBI_TaxID=143451;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], DOMAIN, FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=29706971; DOI=10.3389/fpls.2018.00286;
RA   Liu Y., Lan X., Song S., Yin L., Dry I.B., Qu J., Xiang J., Lu J.;
RT   "In planta functional analysis and subcellular localization of the oomycete
RT   pathogen Plasmopara viticola candidate RXLR effector repertoire.";
RL   Front. Plant Sci. 9:286-286(2018).
CC   -!- FUNCTION: Secreted effector that completely suppresses the host cell
CC       death induced by cell death-inducing proteins.
CC       {ECO:0000269|PubMed:29706971}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:29706971}. Host
CC       nucleus {ECO:0000269|PubMed:29706971}.
CC   -!- DOMAIN: The RxLR-dEER motif acts to carry the protein into the host
CC       cell cytoplasm through binding to cell surface phosphatidylinositol-3-
CC       phosphate. {ECO:0000305|PubMed:29706971}.
CC   -!- SIMILARITY: Belongs to the RxLR effector family. {ECO:0000305}.
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DR   AlphaFoldDB; P0CV48; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
PE   2: Evidence at transcript level;
KW   Host nucleus; Secreted; Signal; Virulence.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..382
FT                   /note="Secreted RxLR effector protein 118"
FT                   /id="PRO_0000447957"
FT   REGION          308..382
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           48..65
FT                   /note="RxLR-dEER"
FT                   /evidence="ECO:0000305|PubMed:29706971"
FT   COMPBIAS        311..362
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   382 AA;  42338 MW;  E749EB26D63B8DBB CRC64;
     MRGAYYVTIA LLVVASSQIS AEFGHQLQAY DHDVTAADDA VAETLAKRSL RGSRDVSNDV
     AIEERTKYSN VIEDGIEMLL RAAEALKEMP RAAVAVKDMP RAEEAVEKMA PIAEQDLLKN
     VIGADEASKR RRAPHGISTQ RTLALPFKEW NTELKQMRGG SVLKKYRSKI KSVHQAFVDL
     CDKDLNPTVT ETALLWGMFD WDVKSYSASA HKHNLIRLAK RYVHKDVVQI QSDDLAWNRW
     NEVSIPLRIG ALNILLNLHY QRWVRMYNIF EQYQSALIGT PVSLELSLGG TTGTSSATAL
     DKHLEVPMNK ASTSKGKSSV FTRSSKRAFD SKTGTTSPSS KHSKMQRSSS PLTESTTSGD
     DPVFTKRSRH GVAVTSLSSI SN