RL11_LEIMA
ID RL11_LEIMA Reviewed; 188 AA.
AC P48157; Q7K6M4;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1996, sequence version 1.
DT 25-MAY-2022, entry version 111.
DE RecName: Full=60S ribosomal protein L11;
GN Name=RPL11; Synonyms=P1421.04; ORFNames=LmjF22.0030;
OS Leishmania major.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=5664;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=NIH S;
RX PubMed=7477109; DOI=10.1016/0166-6851(94)00055-r;
RA Love D.C., Wilson M.E., Mosser D.M.;
RT "Cloning and characterization of the ribosomal l11 gene from Leishmania
RT spp.";
RL Mol. Biochem. Parasitol. 71:261-264(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9477341; DOI=10.1101/gr.8.2.135;
RA Ivens A.C., Lewis S.M., Bagherzadeh A., Zhang L., Chan H.M., Smith D.F.;
RT "A physical map of the Leishmania major Friedlin genome.";
RL Genome Res. 8:135-145(1998).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin;
RX PubMed=16020728; DOI=10.1126/science.1112680;
RA Ivens A.C., Peacock C.S., Worthey E.A., Murphy L., Aggarwal G.,
RA Berriman M., Sisk E., Rajandream M.A., Adlem E., Aert R., Anupama A.,
RA Apostolou Z., Attipoe P., Bason N., Bauser C., Beck A., Beverley S.M.,
RA Bianchettin G., Borzym K., Bothe G., Bruschi C.V., Collins M., Cadag E.,
RA Ciarloni L., Clayton C., Coulson R.M.R., Cronin A., Cruz A.K., Davies R.M.,
RA De Gaudenzi J., Dobson D.E., Duesterhoeft A., Fazelina G., Fosker N.,
RA Frasch A.C., Fraser A., Fuchs M., Gabel C., Goble A., Goffeau A.,
RA Harris D., Hertz-Fowler C., Hilbert H., Horn D., Huang Y., Klages S.,
RA Knights A., Kube M., Larke N., Litvin L., Lord A., Louie T., Marra M.,
RA Masuy D., Matthews K., Michaeli S., Mottram J.C., Mueller-Auer S.,
RA Munden H., Nelson S., Norbertczak H., Oliver K., O'neil S., Pentony M.,
RA Pohl T.M., Price C., Purnelle B., Quail M.A., Rabbinowitsch E.,
RA Reinhardt R., Rieger M., Rinta J., Robben J., Robertson L., Ruiz J.C.,
RA Rutter S., Saunders D., Schaefer M., Schein J., Schwartz D.C., Seeger K.,
RA Seyler A., Sharp S., Shin H., Sivam D., Squares R., Squares S., Tosato V.,
RA Vogt C., Volckaert G., Wambutt R., Warren T., Wedler H., Woodward J.,
RA Zhou S., Zimmermann W., Smith D.F., Blackwell J.M., Stuart K.D.,
RA Barrell B.G., Myler P.J.;
RT "The genome of the kinetoplastid parasite, Leishmania major.";
RL Science 309:436-442(2005).
CC -!- FUNCTION: Component of the ribosome, a large ribonucleoprotein complex
CC responsible for the synthesis of proteins in the cell. The small
CC ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the
CC encoded message by selecting cognate aminoacyl-transfer RNA (tRNA)
CC molecules. The large subunit (LSU) contains the ribosomal catalytic
CC site termed the peptidyl transferase center (PTC), which catalyzes the
CC formation of peptide bonds, thereby polymerizing the amino acids
CC delivered by tRNAs into a polypeptide chain. The nascent polypeptides
CC leave the ribosome through a tunnel in the LSU and interact with
CC protein factors that function in enzymatic processing, targeting, and
CC the membrane insertion of nascent chains at the exit of the ribosomal
CC tunnel. {ECO:0000250|UniProtKB:P0C0W9}.
CC -!- SUBUNIT: Component of the large ribosomal subunit.
CC {ECO:0000250|UniProtKB:P0C0W9}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P0C0W9}. Cytoplasm
CC {ECO:0000250|UniProtKB:P0C0W9}.
CC -!- SIMILARITY: Belongs to the universal ribosomal protein uL5 family.
CC {ECO:0000305}.
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DR EMBL; U16999; AAC46922.1; -; Genomic_DNA.
DR EMBL; FR796400; CAC22698.1; -; Genomic_DNA.
DR EMBL; FR796418; CAJ03765.1; -; Genomic_DNA.
DR RefSeq; XP_001683157.1; XM_001683105.1.
DR RefSeq; XP_888578.1; XM_883485.1.
DR AlphaFoldDB; P48157; -.
DR SMR; P48157; -.
DR STRING; 5664.LmjF.04.0470; -.
DR EnsemblProtists; CAC22698; CAC22698; LMJF_04_0470.
DR EnsemblProtists; CAJ03765; CAJ03765; LMJF_22_0030.
DR GeneID; 3684865; -.
DR GeneID; 5651769; -.
DR KEGG; lma:LMJF_04_0470; -.
DR KEGG; lma:LMJF_22_0030; -.
DR VEuPathDB; TriTrypDB:LmjF.22.0030; -.
DR VEuPathDB; TriTrypDB:LMJLV39_220005200; -.
DR VEuPathDB; TriTrypDB:LMJSD75_220005300; -.
DR eggNOG; KOG0397; Eukaryota.
DR OMA; QTETIKW; -.
DR Proteomes; UP000000542; Chromosome 22.
DR Proteomes; UP000000542; Chromosome 4.
DR GO; GO:0022625; C:cytosolic large ribosomal subunit; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0019843; F:rRNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003735; F:structural constituent of ribosome; IBA:GO_Central.
DR GO; GO:0006412; P:translation; IEA:InterPro.
DR Gene3D; 3.30.1440.10; -; 1.
DR InterPro; IPR002132; Ribosomal_L5.
DR InterPro; IPR031309; Ribosomal_L5_C.
DR InterPro; IPR020929; Ribosomal_L5_CS.
DR InterPro; IPR022803; Ribosomal_L5_dom_sf.
DR InterPro; IPR031310; Ribosomal_L5_N.
DR PANTHER; PTHR11994; PTHR11994; 1.
DR Pfam; PF00281; Ribosomal_L5; 1.
DR Pfam; PF00673; Ribosomal_L5_C; 1.
DR PIRSF; PIRSF002161; Ribosomal_L5; 1.
DR SUPFAM; SSF55282; SSF55282; 1.
DR PROSITE; PS00358; RIBOSOMAL_L5; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Nucleus; Reference proteome; Ribonucleoprotein;
KW Ribosomal protein; RNA-binding; rRNA-binding.
FT CHAIN 1..188
FT /note="60S ribosomal protein L11"
FT /id="PRO_0000125092"
SQ SEQUENCE 188 AA; 21645 MW; 9E70E090C1D0FA5C CRC64;
MVAESKAANP MREIVVKKLC INICVGESGD RLTRASKVLE QLCEQTPVLS RARLTVRTFG
IRRNEKIAVH CTVRGKKAEE LLEKGLKVKE FELKSYNFAD TGSFGFGIDE HIDLGIKYDP
STGIYGMDFY VVLGRRGERV AHRKRKCSRV GHSHHVTKEE AMKWFEKVHD GIIFQAKKKK
KMIRRRRR
