RL11_THEMA
ID RL11_THEMA Reviewed; 141 AA.
AC P29395;
DT 01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 25-MAY-2022, entry version 163.
DE RecName: Full=50S ribosomal protein L11 {ECO:0000255|HAMAP-Rule:MF_00736};
GN Name=rplK {ECO:0000255|HAMAP-Rule:MF_00736}; OrderedLocusNames=TM_0454;
OS Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826
OS / MSB8).
OC Bacteria; Thermotogae; Thermotogales; Thermotogaceae; Thermotoga.
OX NCBI_TaxID=243274;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8;
RX PubMed=1429627; DOI=10.1016/s0021-9258(18)50016-8;
RA Liao D., Dennis P.P.;
RT "The organization and expression of essential transcription translation
RT component genes in the extremely thermophilic eubacterium Thermotoga
RT maritima.";
RL J. Biol. Chem. 267:22787-22797(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8;
RX PubMed=10360571; DOI=10.1038/20601;
RA Nelson K.E., Clayton R.A., Gill S.R., Gwinn M.L., Dodson R.J., Haft D.H.,
RA Hickey E.K., Peterson J.D., Nelson W.C., Ketchum K.A., McDonald L.A.,
RA Utterback T.R., Malek J.A., Linher K.D., Garrett M.M., Stewart A.M.,
RA Cotton M.D., Pratt M.S., Phillips C.A., Richardson D.L., Heidelberg J.F.,
RA Sutton G.G., Fleischmann R.D., Eisen J.A., White O., Salzberg S.L.,
RA Smith H.O., Venter J.C., Fraser C.M.;
RT "Evidence for lateral gene transfer between Archaea and Bacteria from
RT genome sequence of Thermotoga maritima.";
RL Nature 399:323-329(1999).
RN [3]
RP X-RAY CRYSTALLOGRAPHY (2.57 ANGSTROMS).
RX PubMed=10338213; DOI=10.1016/s0092-8674(00)80759-x;
RA Wimberly B.T., Guymon R., McCutcheon J.P., White S.W., Ramakrishnan V.;
RT "A detailed view of a ribosomal active site: the structure of the L11-RNA
RT complex.";
RL Cell 97:491-502(1999).
CC -!- FUNCTION: Forms part of the ribosomal stalk which helps the ribosome
CC interact with GTP-bound translation factors.
CC -!- SUBUNIT: Part of the ribosomal stalk of the 50S ribosomal subunit.
CC Interacts with L10 and the large rRNA to form the base of the stalk.
CC L10 forms an elongated spine to which 3 L12 dimers bind in a sequential
CC fashion forming a heptameric L10(L12)2(L12)2(L12)2 complex.
CC -!- PTM: One or more lysine residues are methylated. {ECO:0000255|HAMAP-
CC Rule:MF_00736}.
CC -!- SIMILARITY: Belongs to the universal ribosomal protein uL11 family.
CC {ECO:0000255|HAMAP-Rule:MF_00736}.
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DR EMBL; Z11839; CAA77859.1; -; Genomic_DNA.
DR EMBL; AE000512; AAD35537.1; -; Genomic_DNA.
DR PIR; B44466; R5HG11.
DR RefSeq; NP_228264.1; NC_000853.1.
DR RefSeq; WP_004081512.1; NZ_CP011107.1.
DR PDB; 1JQM; EM; -; A=2-140.
DR PDB; 1JQS; EM; -; A=2-140.
DR PDB; 1JQT; EM; -; A=2-140.
DR PDB; 1ML5; EM; 14.00 A; l=1-141.
DR PDB; 1MMS; X-ray; 2.57 A; A/B=2-141.
DR PDB; 1MVR; EM; 12.80 A; L=2-141.
DR PDB; 1OLN; NMR; -; A=2-141.
DR PDB; 1PN7; EM; 10.80 A; L=8-140.
DR PDB; 1PN8; EM; 10.80 A; L=8-140.
DR PDB; 1R2W; EM; 9.00 A; A=2-141.
DR PDB; 1R2X; EM; 9.00 A; A=2-141.
DR PDB; 2BCW; EM; 11.20 A; A=8-72.
DR PDB; 2JQ7; NMR; -; A=1-141.
DR PDB; 2K3F; NMR; -; A=1-141.
DR PDB; 4V42; X-ray; 5.50 A; BL=1-141.
DR PDB; 4V4R; X-ray; 5.90 A; BK=1-141.
DR PDB; 4V4S; X-ray; 6.76 A; BK=1-141.
DR PDB; 4V4T; X-ray; 6.46 A; BK=1-141.
DR PDBsum; 1JQM; -.
DR PDBsum; 1JQS; -.
DR PDBsum; 1JQT; -.
DR PDBsum; 1ML5; -.
DR PDBsum; 1MMS; -.
DR PDBsum; 1MVR; -.
DR PDBsum; 1OLN; -.
DR PDBsum; 1PN7; -.
DR PDBsum; 1PN8; -.
DR PDBsum; 1R2W; -.
DR PDBsum; 1R2X; -.
DR PDBsum; 2BCW; -.
DR PDBsum; 2JQ7; -.
DR PDBsum; 2K3F; -.
DR PDBsum; 4V42; -.
DR PDBsum; 4V4R; -.
DR PDBsum; 4V4S; -.
DR PDBsum; 4V4T; -.
DR AlphaFoldDB; P29395; -.
DR BMRB; P29395; -.
DR SMR; P29395; -.
DR IntAct; P29395; 2.
DR MINT; P29395; -.
DR STRING; 243274.THEMA_02420; -.
DR DrugBank; DB02940; (4s)-2-[(1e)-1-Aminoprop-1-Enyl]-4,5-Dihydro-1,3-Thiazole-4-Carboxylic Acid.
DR DrugBank; DB02566; 8-Hydroxy-4-(1-Hydroxyethyl)Quinoline-2-Carboxylic Acid.
DR EnsemblBacteria; AAD35537; AAD35537; TM_0454.
DR KEGG; tma:TM0454; -.
DR eggNOG; COG0080; Bacteria.
DR InParanoid; P29395; -.
DR OMA; CKQFNAK; -.
DR OrthoDB; 1702697at2; -.
DR EvolutionaryTrace; P29395; -.
DR Proteomes; UP000008183; Chromosome.
DR GO; GO:0022625; C:cytosolic large ribosomal subunit; IBA:GO_Central.
DR GO; GO:0015934; C:large ribosomal subunit; IBA:GO_Central.
DR GO; GO:0070180; F:large ribosomal subunit rRNA binding; IBA:GO_Central.
DR GO; GO:0003735; F:structural constituent of ribosome; IBA:GO_Central.
DR GO; GO:0006412; P:translation; IBA:GO_Central.
DR CDD; cd00349; Ribosomal_L11; 1.
DR Gene3D; 1.10.10.250; -; 1.
DR Gene3D; 3.30.1550.10; -; 1.
DR HAMAP; MF_00736; Ribosomal_L11; 1.
DR InterPro; IPR000911; Ribosomal_L11/L12.
DR InterPro; IPR036796; Ribosomal_L11/L12_N_sf.
DR InterPro; IPR006519; Ribosomal_L11_bac-typ.
DR InterPro; IPR020783; Ribosomal_L11_C.
DR InterPro; IPR036769; Ribosomal_L11_C_sf.
DR InterPro; IPR020785; Ribosomal_L11_CS.
DR InterPro; IPR020784; Ribosomal_L11_N.
DR PANTHER; PTHR11661; PTHR11661; 1.
DR Pfam; PF00298; Ribosomal_L11; 1.
DR Pfam; PF03946; Ribosomal_L11_N; 1.
DR SMART; SM00649; RL11; 1.
DR SUPFAM; SSF46906; SSF46906; 1.
DR SUPFAM; SSF54747; SSF54747; 1.
DR TIGRFAMs; TIGR01632; L11_bact; 1.
DR PROSITE; PS00359; RIBOSOMAL_L11; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Methylation; Reference proteome; Ribonucleoprotein;
KW Ribosomal protein; RNA-binding; rRNA-binding.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250"
FT CHAIN 2..141
FT /note="50S ribosomal protein L11"
FT /id="PRO_0000104397"
FT STRAND 9..14
FT /evidence="ECO:0007829|PDB:1MMS"
FT TURN 21..25
FT /evidence="ECO:0007829|PDB:1MMS"
FT HELIX 26..29
FT /evidence="ECO:0007829|PDB:1MMS"
FT TURN 30..32
FT /evidence="ECO:0007829|PDB:1MMS"
FT HELIX 35..45
FT /evidence="ECO:0007829|PDB:1MMS"
FT TURN 46..48
FT /evidence="ECO:0007829|PDB:1MMS"
FT STRAND 51..60
FT /evidence="ECO:0007829|PDB:1MMS"
FT STRAND 62..64
FT /evidence="ECO:0007829|PDB:2JQ7"
FT STRAND 66..70
FT /evidence="ECO:0007829|PDB:1MMS"
FT HELIX 75..83
FT /evidence="ECO:0007829|PDB:1MMS"
FT TURN 92..94
FT /evidence="ECO:0007829|PDB:1MMS"
FT STRAND 98..101
FT /evidence="ECO:0007829|PDB:1MMS"
FT HELIX 102..112
FT /evidence="ECO:0007829|PDB:1MMS"
FT HELIX 113..115
FT /evidence="ECO:0007829|PDB:1MMS"
FT HELIX 121..132
FT /evidence="ECO:0007829|PDB:1MMS"
FT TURN 133..136
FT /evidence="ECO:0007829|PDB:1MMS"
FT STRAND 137..140
FT /evidence="ECO:0007829|PDB:1MMS"
SQ SEQUENCE 141 AA; 15089 MW; 08AD83D090F651A9 CRC64;
MAKKVAAQIK LQLPAGKATP APPVGPALGQ HGVNIMEFCK RFNAETADKA GMILPVVITV
YEDKSFTFII KTPPASFLLK KAAGIEKGSS EPKRKIVGKV TRKQIEEIAK TKMPDLNANS
LEAAMKIIEG TAKSMGIEVV D
