ID   RL122_PLAVT             Reviewed;         352 AA.
AC   P0CV50;
DT   18-SEP-2019, integrated into UniProtKB/Swiss-Prot.
DT   18-SEP-2019, sequence version 1.
DT   25-MAY-2022, entry version 8.
DE   RecName: Full=Secreted RxLR effector protein 122 {ECO:0000303|PubMed:29706971};
DE   Flags: Precursor;
GN   Name=RXLR122 {ECO:0000303|PubMed:29706971};
OS   Plasmopara viticola (Downy mildew of grapevine) (Botrytis viticola).
OC   Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC   Plasmopara.
OX   NCBI_TaxID=143451;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], DOMAIN, FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=29706971; DOI=10.3389/fpls.2018.00286;
RA   Liu Y., Lan X., Song S., Yin L., Dry I.B., Qu J., Xiang J., Lu J.;
RT   "In planta functional analysis and subcellular localization of the oomycete
RT   pathogen Plasmopara viticola candidate RXLR effector repertoire.";
RL   Front. Plant Sci. 9:286-286(2018).
CC   -!- FUNCTION: Secreted effector that acts as an elicitor that induces cell
CC       death in host plant cells. {ECO:0000269|PubMed:29706971}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:29706971}. Host
CC       nucleus {ECO:0000269|PubMed:29706971}.
CC   -!- DOMAIN: The RxLR-dEER motif acts to carry the protein into the host
CC       cell cytoplasm through binding to cell surface phosphatidylinositol-3-
CC       phosphate. {ECO:0000305|PubMed:29706971}.
CC   -!- SIMILARITY: Belongs to the RxLR effector family. {ECO:0000305}.
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DR   AlphaFoldDB; P0CV50; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
PE   2: Evidence at transcript level;
KW   Host nucleus; Secreted; Signal; Virulence.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..352
FT                   /note="Secreted RxLR effector protein 122"
FT                   /id="PRO_0000447959"
FT   REGION          280..352
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           48..65
FT                   /note="RxLR-dEER"
FT                   /evidence="ECO:0000305|PubMed:29706971"
FT   COMPBIAS        299..336
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   352 AA;  39609 MW;  6E590C2FD5592A71 CRC64;
     MRGAYYVLIA LLVVASSQTS AESGHQLQVY DHDFVAADTA AATTLPRQFL RGSRNVPGDL
     AHEERAITSE LVEEGAKLIP RAAENVEEIS RVAEAVGKRP RVAEEDVLNK ASGANEAFKK
     PRNTATDDAF QGISTEQLLP LSYKQWDTEI KSMRIPKPEK YQNNIQSVYD AFVDVCDEDL
     KPTISETARL WNLFDRSFKP LTTRLHQQAL AQFAKEYVLR DELRLKTEWA RMNERTMPNR
     AGMLNMKLNW HFQRWVRMYN KFGERRSELI GTPLNVARSR GGTTGASRGT ALHRHSIVPL
     NAASTSKGKS SVFTERSQRT FDDNTDIASP PSKHIKGQSS ELVEPEGHRS KP