RL12_CAEEL
ID RL12_CAEEL Reviewed; 165 AA.
AC P61866; O62290; Q2EEM7;
DT 07-JUN-2004, integrated into UniProtKB/Swiss-Prot.
DT 07-JUN-2004, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=60S ribosomal protein L12;
GN Name=rpl-12; ORFNames=JC8.3;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Binds directly to 26S ribosomal RNA. {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=a;
CC IsoId=P61866-1; Sequence=Displayed;
CC Name=c;
CC IsoId=P61866-2; Sequence=VSP_020725;
CC -!- SIMILARITY: Belongs to the universal ribosomal protein uL11 family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; Z82274; CAB05226.1; -; Genomic_DNA.
DR EMBL; Z82274; CAJ76933.1; -; Genomic_DNA.
DR PIR; T23150; T23150.
DR RefSeq; NP_001040960.1; NM_001047495.4. [P61866-2]
DR RefSeq; NP_502542.1; NM_070141.6. [P61866-1]
DR AlphaFoldDB; P61866; -.
DR SMR; P61866; -.
DR BioGRID; 43368; 83.
DR DIP; DIP-26259N; -.
DR IntAct; P61866; 1.
DR STRING; 6239.JC8.3a; -.
DR MoonProt; P61866; -.
DR iPTMnet; P61866; -.
DR EPD; P61866; -.
DR PaxDb; P61866; -.
DR EnsemblMetazoa; JC8.3a.1; JC8.3a.1; WBGene00004424. [P61866-1]
DR EnsemblMetazoa; JC8.3c.1; JC8.3c.1; WBGene00004424. [P61866-2]
DR GeneID; 178279; -.
DR KEGG; cel:CELE_JC8.3; -.
DR UCSC; JC8.3a.2; c. elegans. [P61866-1]
DR CTD; 178279; -.
DR WormBase; JC8.3a; CE17986; WBGene00004424; rpl-12. [P61866-1]
DR WormBase; JC8.3c; CE39743; WBGene00004424; rpl-12. [P61866-2]
DR eggNOG; KOG0886; Eukaryota.
DR GeneTree; ENSGT00390000006922; -.
DR HOGENOM; CLU_074237_5_0_1; -.
DR InParanoid; P61866; -.
DR OMA; QPPHDVI; -.
DR OrthoDB; 1279477at2759; -.
DR PhylomeDB; P61866; -.
DR Reactome; R-CEL-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR Reactome; R-CEL-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR Reactome; R-CEL-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR Reactome; R-CEL-72689; Formation of a pool of free 40S subunits.
DR Reactome; R-CEL-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR Reactome; R-CEL-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR Reactome; R-CEL-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR SignaLink; P61866; -.
DR PRO; PR:P61866; -.
DR Proteomes; UP000001940; Chromosome IV.
DR Bgee; WBGene00004424; Expressed in material anatomical entity and 5 other tissues.
DR GO; GO:0022625; C:cytosolic large ribosomal subunit; IBA:GO_Central.
DR GO; GO:0015934; C:large ribosomal subunit; IBA:GO_Central.
DR GO; GO:0070180; F:large ribosomal subunit rRNA binding; IBA:GO_Central.
DR GO; GO:0003735; F:structural constituent of ribosome; IBA:GO_Central.
DR GO; GO:0000381; P:regulation of alternative mRNA splicing, via spliceosome; IDA:CAFA.
DR GO; GO:0006412; P:translation; IBA:GO_Central.
DR CDD; cd00349; Ribosomal_L11; 1.
DR Gene3D; 1.10.10.250; -; 1.
DR Gene3D; 3.30.1550.10; -; 1.
DR HAMAP; MF_00736; Ribosomal_L11; 1.
DR InterPro; IPR000911; Ribosomal_L11/L12.
DR InterPro; IPR036796; Ribosomal_L11/L12_N_sf.
DR InterPro; IPR020783; Ribosomal_L11_C.
DR InterPro; IPR036769; Ribosomal_L11_C_sf.
DR InterPro; IPR020785; Ribosomal_L11_CS.
DR InterPro; IPR020784; Ribosomal_L11_N.
DR PANTHER; PTHR11661; PTHR11661; 1.
DR Pfam; PF00298; Ribosomal_L11; 1.
DR Pfam; PF03946; Ribosomal_L11_N; 1.
DR SMART; SM00649; RL11; 1.
DR SUPFAM; SSF46906; SSF46906; 1.
DR SUPFAM; SSF54747; SSF54747; 1.
DR PROSITE; PS00359; RIBOSOMAL_L11; 1.
PE 3: Inferred from homology;
KW Alternative splicing; Reference proteome; Ribonucleoprotein;
KW Ribosomal protein; RNA-binding.
FT CHAIN 1..165
FT /note="60S ribosomal protein L12"
FT /id="PRO_0000104460"
FT VAR_SEQ 1..115
FT /note="Missing (in isoform c)"
FT /evidence="ECO:0000305"
FT /id="VSP_020725"
SQ SEQUENCE 165 AA; 17831 MW; 0ECCD325C5347CBF CRC64;
MPPKFDPTEI KIVYLRCVGG EVGATSALAP KVGPLGLSPK KIGEDIAKAT QDWKGLKVTC
KLTIQNRVAK IDVVPSAASL IVKELKEPPR DRKKVKNVKH NGDLTVDTII KIARIMRPRS
MAKKLEGTVK EILGTAQSVG CTIDGQHPHD IIESIANGEI EIPAQ
