RL12_DICDI
ID RL12_DICDI Reviewed; 166 AA.
AC Q54J50;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 100.
DE RecName: Full=60S ribosomal protein L12;
GN Name=rpl12; ORFNames=DDB_G0288295;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP PROTEIN SEQUENCE OF 17-31 AND 150-166, AND IDENTIFICATION BY MASS
RP SPECTROMETRY.
RA Bienvenut W.V., Veltman D.M., Insall R.H.;
RL Submitted (JAN-2010) to UniProtKB.
CC -!- SIMILARITY: Belongs to the universal ribosomal protein uL11 family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAFI02000109; EAL63290.1; -; Genomic_DNA.
DR RefSeq; XP_636797.1; XM_631705.1.
DR PDB; 5AN9; EM; 3.30 A; D=1-166.
DR PDB; 5ANB; EM; 4.10 A; D=1-166.
DR PDB; 5ANC; EM; 4.20 A; D=1-166.
DR PDB; 6QKL; EM; 3.30 A; D=1-166.
DR PDBsum; 5AN9; -.
DR PDBsum; 5ANB; -.
DR PDBsum; 5ANC; -.
DR PDBsum; 6QKL; -.
DR AlphaFoldDB; Q54J50; -.
DR SMR; Q54J50; -.
DR STRING; 44689.DDB0229950; -.
DR PaxDb; Q54J50; -.
DR EnsemblProtists; EAL63290; EAL63290; DDB_G0288295.
DR GeneID; 8626554; -.
DR KEGG; ddi:DDB_G0288295; -.
DR dictyBase; DDB_G0288295; rpl12.
DR eggNOG; KOG0886; Eukaryota.
DR HOGENOM; CLU_074237_5_0_1; -.
DR InParanoid; Q54J50; -.
DR OMA; QPPHDVI; -.
DR PhylomeDB; Q54J50; -.
DR Reactome; R-DDI-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR Reactome; R-DDI-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR Reactome; R-DDI-72689; Formation of a pool of free 40S subunits.
DR Reactome; R-DDI-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR Reactome; R-DDI-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR Reactome; R-DDI-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR PRO; PR:Q54J50; -.
DR Proteomes; UP000002195; Chromosome 5.
DR GO; GO:0022625; C:cytosolic large ribosomal subunit; IBA:GO_Central.
DR GO; GO:0015934; C:large ribosomal subunit; IBA:GO_Central.
DR GO; GO:0070180; F:large ribosomal subunit rRNA binding; IBA:GO_Central.
DR GO; GO:0003735; F:structural constituent of ribosome; IBA:GO_Central.
DR GO; GO:0006412; P:translation; IBA:GO_Central.
DR CDD; cd00349; Ribosomal_L11; 1.
DR Gene3D; 1.10.10.250; -; 1.
DR Gene3D; 3.30.1550.10; -; 1.
DR HAMAP; MF_00736; Ribosomal_L11; 1.
DR InterPro; IPR000911; Ribosomal_L11/L12.
DR InterPro; IPR036796; Ribosomal_L11/L12_N_sf.
DR InterPro; IPR020783; Ribosomal_L11_C.
DR InterPro; IPR036769; Ribosomal_L11_C_sf.
DR InterPro; IPR020784; Ribosomal_L11_N.
DR PANTHER; PTHR11661; PTHR11661; 1.
DR Pfam; PF00298; Ribosomal_L11; 1.
DR Pfam; PF03946; Ribosomal_L11_N; 1.
DR SMART; SM00649; RL11; 1.
DR SUPFAM; SSF46906; SSF46906; 1.
DR SUPFAM; SSF54747; SSF54747; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Direct protein sequencing; Reference proteome;
KW Ribonucleoprotein; Ribosomal protein.
FT CHAIN 1..166
FT /note="60S ribosomal protein L12"
FT /id="PRO_0000323436"
FT STRAND 15..17
FT /evidence="ECO:0007829|PDB:5AN9"
FT STRAND 24..26
FT /evidence="ECO:0007829|PDB:5AN9"
FT HELIX 32..35
FT /evidence="ECO:0007829|PDB:5AN9"
FT HELIX 40..50
FT /evidence="ECO:0007829|PDB:5AN9"
FT STRAND 52..54
FT /evidence="ECO:0007829|PDB:5AN9"
FT HELIX 78..85
FT /evidence="ECO:0007829|PDB:5AN9"
FT STRAND 91..97
FT /evidence="ECO:0007829|PDB:5AN9"
FT HELIX 107..114
FT /evidence="ECO:0007829|PDB:5AN9"
FT TURN 125..127
FT /evidence="ECO:0007829|PDB:5AN9"
FT HELIX 129..133
FT /evidence="ECO:0007829|PDB:5AN9"
FT STRAND 135..137
FT /evidence="ECO:0007829|PDB:5AN9"
FT STRAND 144..146
FT /evidence="ECO:0007829|PDB:5AN9"
FT TURN 148..150
FT /evidence="ECO:0007829|PDB:5AN9"
FT STRAND 151..154
FT /evidence="ECO:0007829|PDB:5AN9"
FT TURN 161..163
FT /evidence="ECO:0007829|PDB:5AN9"
SQ SEQUENCE 166 AA; 17781 MW; CCC80B5C096BD318 CRC64;
MPPKVDPSEK VEVFLRVCGG EAGAMSTLAP KLGPLGVSPK KVGDDIAKAT QPWKGMKVSV
KLTIQNRIAV PEVLPSASAL VIKALKEPPR DRKKEKNIKH NGNIPLEEIC KIAKTMRFKS
LAVDFKGSVL EILGTAHSVG CKVNGKSPRD IQAGIQSGEI EVVEPK
